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Research Article Free access | 10.1172/JCI106351

The effect of cardiac disease on hemoglobin-oxygen binding

R. D. Woodson, J. D. Torrance, S. D. Shappell, and C. Lenfant

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105

Find articles by Woodson, R. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105

Find articles by Torrance, J. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105

Find articles by Shappell, S. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105

Find articles by Lenfant, C. in: PubMed | Google Scholar

Published July 1, 1970 - More info

Published in Volume 49, Issue 7 on July 1, 1970
J Clin Invest. 1970;49(7):1349–1356. https://doi.org/10.1172/JCI106351.
© 1970 The American Society for Clinical Investigation
Published July 1, 1970 - Version history
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Abstract

The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O2) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]VVO2) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.

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