Usage Information

Warfarin metabolism in man: identification of metabolites in urine
Richard J. Lewis, William F. Trager
Richard J. Lewis, William F. Trager
Published May 1, 1970
Citation Information: J Clin Invest. 1970;49(5):907-913. https://doi.org/10.1172/JCI106310.
View: Text | PDF
Research Article Article has an altmetric score of 3

Warfarin metabolism in man: identification of metabolites in urine

Abstract

After administration of the coumarin anticoagulant racemic warfarin to normal humans, seven fluorescent compounds were chromatographically separated from extracts of their urine. Four of these were identified using mass spectrometry, thin-layer chromatography, and ultraviolet absorption spectroscopy. One metabolic pathway, reduction of the acetonyl side chain of warfarin, resulted in the formation of a second asymmetric carbon atom, and two diastereoisomer alcohols were identified. These warfarin alcohols are structurally similar to pharmacologically active coumarin derivatives. They have not been reported in animal studies. In addition, 6- and 7-hydroxywarfarin were identified. These are the first studies to document the metabolic fate of warfarin in the normal human.

Authors

Richard J. Lewis, William F. Trager

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 201 9
PDF 70 15
Scanned page 246 10
Citation downloads 46 0
Totals 563 34
Total Views 597
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement