Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Abnormal rheology of oxygenated blood in sickle cell anemia
Shu Chien, … , Shunichi Usami, John F. Bertles
Shu Chien, … , Shunichi Usami, John F. Bertles
Published April 1, 1970
Citation Information: J Clin Invest. 1970;49(4):623-634. https://doi.org/10.1172/JCI106273.
View: Text | PDF
Research Article Article has an altmetric score of 1

Abnormal rheology of oxygenated blood in sickle cell anemia

  • Text
  • PDF
Abstract

The viscosity of oxygenated blood from patients with sickle cell anemia (Hb SS disease) was found to be abnormally increased, a property which contrasts with the well recognized viscous aberration produced by deoxygenation of Hb SS blood. Experiments designed to explain this finding led to considerations of deformation and aggregation, primary determinants of the rheologic behavior of erythrocytes as they traverse the microcirculation. Deformability of erythrocytes is in turn dependent upon internal viscosity (i.e. the state and concentration of hemoglobin in solution) and membrane flexibility. Definition of the contribution made by each of these properties to the abnormal viscosity of oxygenated Hb SS blood was made possible by analysis of viscosity measurements, made over a wide range of shear rates and cell concentrations, on Hb SS erythrocytes and normal erythrocytes suspended in Ringer's solution (where aggregation does not occur) and in plasma. Similar measurements were made on the two cell types separated by ultracentrifugation of Hb SS erythrocytes: high density erythrocytes composed of 50 to 70% irreversibly “sickled” cells (ISC) and low density erythrocytes composed of over 95% non-ISC.

Authors

Shu Chien, Shunichi Usami, John F. Bertles

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 1952 Total
Citations: 2 2 3 6 9 6 7 13 10 7 8 4 6 4 6 1 2 2 2 5 6 1 1 3 2 1 1 2 1 3 3 3 2 2 5 1 1 7 3 4 7 6 2 6 12 3 9 3 6 4 4 3 1 1 2 1 227
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (227)

Title and authors Publication Year
Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease
Williams DC, Szafraniec HM, Wood DK
Biophysics Reviews 2025
A novel red blood cell deformability biomarker is associated with hemolysis and vaso-occlusive crises in sickle cell disease.
Sahun M, Bernit E, Atwell S, Hornung A, Charrier AM, Agouti I, Bonello-Palot N, Cerino M, Helfer E, Badens C, Viallat A
Scientific reports 2025
Shell buckling for programmable metafluids.
Djellouli A, Van Raemdonck B, Wang Y, Yang Y, Caillaud A, Weitz D, Rubinstein S, Gorissen B, Bertoldi K
Nature 2024
Gene-environmental influence of space and microgravity on red blood cells with sickle cell disease
Igbineweka NE, van Loon JJ
NPJ Genomic Medicine 2024
Mathematical Analysis for the Flow of Sickle Red Blood Cells in Microvessels for Bio Medical Application.
Chaturvedi P, Shah SR
The Yale journal of biology and medicine 2023
In silico modeling of patient-specific blood rheology in type 2 diabetes mellitus.
Han K, Ma S, Sun J, Xu M, Qi X, Wang S, Li L, Li X
Biophysical Journal 2023
The stress-free state of human erythrocytes: Data-driven inference of a transferable RBC model.
Amoudruz L, Economides A, Arampatzis G, Koumoutsakos P
Biophysical Journal 2023
Dynamics of Individual Red Blood Cells Under Shear Flow: A Way to Discriminate Deformability Alterations.
Atwell S, Badens C, Charrier A, Helfer E, Viallat A
Frontiers in physiology 2022
Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology.
Trejo-Soto C, Lázaro GR, Pagonabarraga I, Hernández-Machado A
Membranes 2022
Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen.
Sun J, Han K, Xu M, Li L, Qian J, Li L, Li X
Frontiers in physiology 2022
Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate.
Trejo-Soto C, Hernández-Machado A
Micromachines 2022
Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy.
Kasireddy N, Orie JC, Khismatullin DB
Lab on a Chip 2022
Cardiovascular consequences of sickle cell disease.
Palomarez A, Jha M, Medina Romero X, Horton RE
2022
Cardiac pathophysiology in sickle cell disease
OT Gbotosho, M Taylor, P Malik
Journal of Thrombosis and Thrombolysis 2021
Molecular rotors as intracellular probes of red blood cell stiffness
A Briole, T Podgorski, B Abou
Soft Matter 2021
Microrheometer for Biofluidic Analysis: Electronic Detection of the Fluid-Front Advancement
L Méndez-Mora, M Cabello-Fusarés, J Ferré-Torres, C Riera-Llobet, S Lopez, C Trejo-Soto, T Alarcón, A Hernandez-Machado
MICROMACHINES-BASEL 2021
Computational modeling of biomechanics and biorheology of heated red blood cells
ZL Liu, H Li, Y Qiang, P Buffet, M Dao, GE Karniadakis
Biophysical Journal 2021
Hemorheology: the critical role of flow type in blood viscosity measurements
E Javadi, S Jamali
Soft Matter 2021
Axial and Nonaxial Migration of Red Blood Cells in a Microtube
N Takeishi, H Yamashita, T Omori, N Yokoyama, M Sugihara-Seki
MICROMACHINES-BASEL 2021
Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity
SB Keller, JM Bumpus, JC Gatenby, E Yang, AA Kassim, C Dampier, JC Gore, AK Buck
Cardiovascular Engineering and Technology 2021
In silico biophysics and hemorheology of blood hyperviscosity syndrome
E Javadi, Y Deng, GE Karniadakis, S Jamali
Biophysical Journal 2021
Bio-Mechanical and Bio-Rheological Aspects of Sickle Red Cells in Microcirculation: A Mathematical Modelling Approach
P Chaturvedi, R Kumar, SR Shah
Physics of Fluids 2021
Systematic Review of Crizanlizumab: A New Parenteral Option to Reduce Vaso‐occlusive Pain Crises in Patients with Sickle Cell Disease
J Han, SL Saraf, VR Gordeuk
Pharmacotherapy 2020
An experimental erythrocyte rigidity index (Ri) and its correlations with Transcranial Doppler velocities (TAMMV), Gosling Pulsatility Index PI, hematocrit, hemoglobin concentration and red cell distribution width (RDW)
AV Cardoso, J Chalmers
PloS one 2020
Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease
E Kucukal, Y Man, A Hill, S Liu, A Bode, R An, J Kadambi, JA Little, UA Gurkan
American Journal of Hematology 2020
Drag-reducing polymers improve hepatic vaso-occlusion in SCD mice
D Crompton, R Vats, T Pradhan-Sundd, P Sundd, MV Kameneva
Blood Advances 2020
Beta Thalassemia
M Zakaria, T Hassan
2020
The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease
A Adekile
Medical Principles and Practice 2020
Sickle cell microvascular paradox—oxygen supply‐demand mismatch
JA Detterich, R Kato, A Bush, P Chalacheva, D Ponce, MD Zoysa, P Shah, MC Khoo, HJ Meiselman, TD Coates, JC Wood
American Journal of Hematology 2019
Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?
E Soya, C Makowski, S Blaise
International Wound Journal 2019
Myocardial Infarction
B Pamukçu
2019
A Lifetime Achievement in Bioengineering: Professor Shu Chien
S Weinbaum, YS Li, GW Schmid-Schönbein
Annals of Biomedical Engineering 2019
Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease
OO Olubiyi, MO Olagunju, B Strodel
Molecules (Basel, Switzerland) 2019
Measurements of human blood viscoelasticity and thixotropy under steady and transient shear and constitutive modeling thereof
JS Horner, MJ Armstrong, NJ Wagner, AN Beris
Journal of Rheology 2019
Haemorheology in dilute, semi-dilute and dense suspensions of red blood cells
N Takeishi, ME Rosti, Y Imai, S Wada, L Brandt
Journal of Fluid Mechanics 2019
Inflammation in sickle cell disease
N Conran, JD Belcher, P Connes
Clinical hemorheology and microcirculation 2018
Sickle Cell Disease: Advances in Treatment
RV Gardner
The Ochsner journal 2018
Shape oscillations of single blood drops: applications to human blood and sickle cell disease
VA Hosseinzadeh, C Brugnara, RG Holt
Scientific Reports 2018
Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy?
JA Detterich, P Connes
Clinical hemorheology and microcirculation 2018
Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery
YF Wu, PS Hsu, CS Tsai, PC Pan, YL Chen
Scientific Reports 2018
Erythrocyte Aggregation and Blood Viscosity is Similar in Homozygous Sickle Cell Disease Patients with and without Leg Ulcers
A Bowers, W Duncan, D Pepple
International Journal of Angiology 2018
Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour
M de Haan, G Zavodszky, V Azizi, A Hoekstra
Applied Sciences 2018
Effects of ex vivo aging and storage temperature on blood viscosity
JS Horner, AN Beris, DS Woulfe, NJ Wagner
Clinical hemorheology and microcirculation 2018
Plasma Dynamic Viscosity Determined by NMR
MA Guevara, YM Torres, JC Naranjo, NR Suárez, LC Beyries, MA Feliu, TS Boada, IC Reyes, J Philippé
Applied Magnetic Resonance 2018
Evidence-Based Emergency Imaging
A Kelly, P Cronin, S Puig, KE Applegate
2018
Measuring success: utility of biomarkers in sickle cell disease clinical trials and care
R Kalpatthi, EM Novelli
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2018
Emerging pharmacotherapeutic approaches for the management of sickle cell disease
L Torres, N Conran
Expert Opinion on Pharmacotherapy 2018
Lateral vesicle migration in a bounded shear flow: Viscosity contrast leads to off-centered solutions
A Nait-Ouhra, A Guckenberger, A Farutin, H Ez-Zahraouy, A Benyoussef, S Gekle, C Misbah
Physical Review Fluids 2018
Biomechanics and biorheology of red blood cells in sickle cell anemia
X Li, M Dao, G Lykotrafitis, GE Karniadakis
Journal of Biomechanics 2017
Computational Biomechanics of Human Red Blood Cells in Hematological Disorders
X Li, H Li, HY Chang, G Lykotrafitis, GE Karniadakis
Journal of Biomechanical Engineering 2017
Patient-specific modeling of individual sickle cell behavior under transient hypoxia
X Li, E Du, M Dao, S Suresh, GE Karniadakis, AD McCulloch
PLoS computational biology 2017
Photoplethysmography for the Assessment of Haemorheology
H Njoum, PA Kyriacou
Scientific Reports 2017
Novel in vivo and in vitro techniques to image and model the cerebral vasculature in sickle cell disease
EM Buckley, MO Platt, WA Lam
Blood Cells, Molecules, and Diseases 2017
On-chip RBC deformability checker embedded with vision analyzer
M Kaneko, T Ishida, CH Tsai, H Ito, M Chimura, T Taniguchi, T Ohtani, Y Sakata
2017
Micro- and macrovascular function in children with sickle cell anaemia and sickle cell haemoglobin C disease
B Möckesch, K Charlot, S Jumet, M Romana, L Divialle-Doumdo, MD Hardy-Dessources, M Petras, B Tressieres, V Tarer, O Hue, M Etienne-Julan, P Connes, S Antoine-Jonville
Blood cells, molecules & diseases 2017
Front microrheology of the non-Newtonian behaviour of blood: scaling theory of erythrocyte aggregation by aging
C Trejo-Soto, E Costa-Miracle, I Rodriguez-Villarreal, J Cid, M Castro, T Alarcon, A Hernandez-Machado
Soft Matter 2017
Particles in Flows
T Bodnár, GP Galdi, Š Nečasová
2017
Microfluidic analysis of red blood cell deformability as a means to assess hemin-induced oxidative stress resulting from Plasmodium falciparum intraerythrocytic parasitism
K Matthews, SP Duffy, ME Myrand-Lapierre, RR Ang, L Li, MD Scott, H Ma
Integrative Biology 2017
Impaired renal endothelial nitric oxide synthase and reticulocyte production as modulators of hypertension induced by rHuEPO in the rat
S Ribeiro, P Garrido, J Fernandes, H Vala, P Rocha-Pereira, E Costa, L Belo, F Reis, A Santos-Silva
Life Sciences 2016
Nonmalignant Hematology
RT Means
Nonmalignant Hematology 2016
Original Research: Sickle cell anemia and pediatric strokes: Computational fluid dynamics analysis in the middle cerebral artery
CP Rivera, A Veneziani, RE Ware, MO Platt
Experimental biology and medicine (Maywood, N.J.) 2016
Guidelines on red cell transfusion in sickle cell disease. Part I: principles and laboratory aspects
BA Davis, S Allard, A Qureshi, JB Porter, S Pancham, N Win, G Cho, K Ryan
British Journal of Haematology 2016
Biomechanics and biorheology of red blood cells in sickle cell anemia
X Li, M Dao, G Lykotrafitis, GE Karniadakis
Journal of Biomechanics 2016
Water Efflux in Red Blood Cells of Sickle Cell Patients under Spontaneous Deoxygenation
MA Guevara, YM Torres, JC Naranjo, AR Aguilera, LC Beyrio, MA Felue, TS Brada, J Philippé
Journal of Biosciences and Medicines 2016
Structure-Based Mechanics of Tissues and Organs
GS Kassab, MS Sacks
2016
Endothelial cells and cathepsins: biochemical and biomechanical regulation
MO Platt, WA Shockey
Biochimie 2015
Obstructive sleep apnea and sickle cell disease: Towards hemorheological abnormalities and vascular dysfunction worsening
P Connes
Sleep Medicine Reviews 2015
The role of blood rheology in sickle cell disease
P Connes, T Alexy, J Detterich, M Romana, MD Hardy-Dessources, SK Ballas
Blood Reviews 2015
Dynamic and rheological properties of soft biological cell suspensions
A Yazdani, X Li, GE Karniadakis
Rheologica Acta 2015
Manifestaciones cardiovasculares de anemia de células falciformes
F Manzur, K Ángel, H Corrales
Revista Colombiana de Cardiología 2015
Biofluid Mechanics
DA Rubenstein, W Yin, MD Frame
Biofluid Mechanics 2015
Patient-specific blood rheology in sickle-cell anaemia
X Li, E Du, H Lei, YH Tang, M Dao, S Suresh, GE Karniadakis
Interface Focus 2015
The systemic vascular resistance response: a cardiovascular response modulating blood viscosity with implications for primary hypertension and certain anemias
GD Sloop, JJ Weidman, JA st. Cyr
Therapeutic advances in cardiovascular disease 2015
Elevated Pulse Pressure is Associated with Hemolysis, Proteinuria and Chronic Kidney Disease in Sickle Cell Disease
EM Novelli, M Hildesheim, C Rosano, R Vanderpool, M Simon, GJ Kato, MT Gladwin, D Guerrot
PloS one 2014
α-Thalassemia Does Not Seem to Influence Erythrocyte Deformability in Sickle Cell Trait Carriers
A Vayá, S Collado, R Alis, B Vera, M Romagnoli, E Barragán
Hemoglobin 2014
High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia
M Grau, A Mozar, K Charlot, Y Lamarre, L Weyel, F Suhr, B Collins, S Jumet, MD Hardy-Dessources, M Romana, N Lemonne, M Etienne-Julan, S Antoine-Jonville, W Bloch, P Connes
British Journal of Haematology 2014
Blood Thixotropy in Patients with Sickle Cell Anaemia: Role of Haematocrit and Red Blood Cell Rheological Properties
J Vent-Schmidt, X Waltz, M Romana, MD Hardy-Dessources, N Lemonne, M Billaud, M Etienne-Julan, P Connes, W Lam
PloS one 2014
Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease
X Waltz, M Romana, ML Lalanne-Mistrih, RF Machado, Y Lamarre, V Tarer, MD Hardy-Dessources, B Tressières, L Divialle-Doumdo, M Petras, F Maillard, M Etienne-Julan, P Connes
Haematologica 2013
Microfluidic analysis of cellular deformability of normal and oxidatively damaged red blood cells
JM Kwan, Q Guo, DL Kyluik-Price, H Ma, MD Scott
American Journal of Hematology 2013
Hematological and hemorheological Determinants of the Six-Minute Walk Test Performance in Children with Sickle Cell Anemia
X Waltz, M Romana, MD Hardy-Dessources, Y Lamarre, L Divialle-Doumdo, M Petras, V Tarer, R Hierso, KC Baltyde, B Tressières, ML Lalanne-Mistrih, F Maillard, O Hue, M Etienne-Julan, P Connes, W Lam
PloS one 2013
A Divergent Artiodactyl MYADM-like Repeat Is Associated with Erythrocyte Traits and Weight of Lamb Weaned in Domestic Sheep
MV Gonzalez, MR Mousel, DR Herndon, Y Jiang, BP Dalrymple, JO Reynolds, WC Johnson, LM Herrmann-Hoesing, SN White, S Moore
PloS one 2013
Severe proliferative retinopathy is associated with blood hyperviscosity in sickle cell hemoglobin-C disease but not in sickle cell anemia
Clément Lemaire, Yann Lamarre, Nathalie Lemonne, Xavier Waltz, Sadri Chahed, Florence Cabot, Ioana Botez, Benoit Tressieres, Marie-Laure Lalanne-Mistrih, Maryse Etienne-Julan, Philippe Connes
Clinical hemorheology and microcirculation 2013
Evidence-Based Neuroimaging Diagnosis and Treatment
LS Medina, PC Sanelli, JG Jarvik
2013
Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient
HS Byun, TR Hillman, JM Higgins, M Diez-Silva, Z Peng, M Dao, RR Dasari, S Suresh, YK Park
Acta Biomaterialia 2012
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Sickle-cell disease and the heart: review of the current literature
E Voskaridou, D Christoulas, E Terpos
British Journal of Haematology 2012
CAPILLARY VISCOMETER FOR FULLY AUTOMATED MEASUREMENT OF THE CONCENTRATION AND SHEAR DEPENDENCE OF THE VISCOSITY OF MACROMOLECULAR SOLUTIONS
A Grupi, AP Minton
Analytical Chemistry 2012
Atomic Force Microscopy in Biomedical Research
PC Braga, D Ricci
2011
Atomic Force Microscopy in Biomedical Research
PC Braga, D Ricci
2011
Atomic Force Microscopy in Biomedical Research
PC Braga, D Ricci
2011
Atomic Force Microscopy in Biomedical Research
PC Braga, D Ricci
2011
Pulmonary Vascular Resistance and Viscosity: The Forgotten Factor
JI Hoffman
Pediatric Cardiology 2011
Effects of Ascorbic Acid Intake on the Intima-Media Thickness and Blood Flow Velocities of the Carotid Artery in Patients With Sickle Cell Anemia
OA Olowoyeye, SI Jaja, MO Kehinde, GO Awosanya, NK Irurhe, AA Adeyomoye, KO Soyebi, RA Arogundade, OM Adekunle, BK Soneye, OO Tubi
Journal of Diagnostic Medical Sonography 2011
Sickle Cell Biomechanics
GA Barabino, MO Platt, DK Kaul
Annual Review of Biomedical Engineering 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
J Tripette, T Alexy, MD Hardy-Dessources, D Mougenel, E Beltan, T Chalabi, R Chout, M Etienne-Julan, O Hue, HJ Meiselman, P Connes
Haematologica 2009
Physiological Responses of Sickle Cell Trait Carriers during Exercise
P Connes, H Reid, MD Hardy-Dessources, E Morrison, O Hue
Sports Medicine 2008
Physiological Responses of Sickle Cell Trait Carriers during Exercise:
P Connes, H Reid, MD Hardy-Dessources, E Morrison, O Hue
Sports Medicine 2008
Biomechanics
R Hochmuth, R Waugh
Biomechanics 2007
Limb amputation in hemoglobin SC disease after application of ice and elevation
S Saleem, L Rice
American Journal of Hematology 2007
Electrical Engineering Handbook
B Gratt
Medical Devices and Systems 2006
Etiology of strokes in children with sickle cell anemia
MR DeBaun, CP Derdeyn, RC McKinstry
Mental Retardation and Developmental Disabilities Research Reviews 2006
Hémorhéologie clinique. Concept, physiopathologie et applications aux maladies vasculaires
MR Boisseau
EMC - Angéiologie 2006
Hematological parameters in sickle cell anemia patients with and without priapism
Sagir G Ahmed, Umma A Ibrahim, Abba W Hassan
Annals of Saudi medicine 2006
Hematological parameters in sick cell anemia patients with and without priapism
Ahmed SG, Ibrahim UA, Hassan AW
Annals of Saudi medicine 2006
Does Higher Red Blood Cell (RBC) Lactate Transporter Activity Explain Impaired RBC Deformability in Sickle Cell Trait?
P Connes, F Sara, MD Hardy-Dessources, M Etienne-Julan, O Hue
The Japanese Journal of Physiology 2005
Arterial Blood Pressure and Hyperviscosity in Sickle Cell Disease
CS Johnson
Hematology/Oncology Clinics of North America 2005
Sickle Cell Vaso-Occlusion
EY Chiang, PS Frenette
Hematology/Oncology Clinics of North America 2005
Hémorrhéologie et cardiologie. Concept, physiopathologie, applications aux affections cardiologiques
MR Boisseau
EMC - Cardiologie-Angéiologie 2005
The modified Casson’s equation and its application to pipe flows of shear-thickening fluid
H Xue
Acta Mechanica Sinica 2005
Hemorheology, Sickle Cell Trait, and ??-Thalassemia in Athletes: Effects of Exercise:
GR Monchanin, P Connes, D Wouassi, A Francina, B Djoda, PE Banga, FO Owona, P Thiriet, RL Massarelli, C Martin
Medicine and Science in Sports and Exercise 2005
Evidence for a mechanosensitive calcium influx into red cells
MC Brain, C Pihl, L Robertson, CB Brown
Blood Cells, Molecules, and Diseases 2004
Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity
J Vogel, I Kiessling, K Heinicke, T Stallmach, P Ossent, O Vogel, M Aulmann, T Frietsch, H Schmid-Schönbein, W Kuschinsky, M Gassmann
Blood 2003
Myocardial infarction in sickle cell disease
IA Mansi, F Rosner
Journal of the National Medical Association 2002
Mechanics and Deformability of Hematocytes
R Waugh, R Hochmuth
Biomechanics Principles and Applications 2002
Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis
S Burns, MO Arcasoy, L Li, E Kurian, K Selander, PD Emanuel, KW Harris
Blood 2002
Techniques for blood administration in sickle cell patients
JR Eckman
Seminars in Hematology 2001
The malaria-infected red blood cell: structural and functional changes.
Cooke BM, Mohandas N, Coppel RL
Advances in Parasitology 2001
New Views of Sickle Cell Disease Pathophysiology and Treatment
WF Rosse, M Narla, LD Petz, MH Steinberg
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2000
Disseminated Thrombosis and Bone Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol
A Nyska, RR Maronpot, PH Long, JH Roycroft, JR Hailey, GS Travlos, BI Ghanayem
Toxicologic pathology 1999
Effect of erythrocytapheresis on arterial oxygen saturation and hemoglobin oxygen affinity in patients with sickle cell disease
K Uchida, WR Rackoff, K Ohene-Frempong, HC Kim, MP Reilly, T Asakura
American Journal of Hematology 1998
Advances in Protein Chemistry
CM Silva, J Isgaard, MO Thorner
Advances in Protein Chemistry 1998
A comparison of the dielectric behaviour of human haemoglobin SC with SS and AA in solution
AA Laogun, EH Agba, NO Ajayi
Physics in Medicine and Biology 1997
PATHOPHYSIOLOGY OF VASO-OCCLUSION
SK Ballas, N Mohandas
Hematology/Oncology Clinics of North America 1996
Percentage of Reversibly and Irreversibly Sickled Cells Are Altered by the Method of Blood Drawing and Storage Conditions
T Asakura, T Hirota, AT Nelson, MP Reilly, K Ohene-Frempong
Blood Cells, Molecules, and Diseases 1996
Modulation of the Phenotypic Diversity of Sickle Cell Anemia
MH Steinberg
Hemoglobin 1996
Blood transfusion in pregnancies complicated by maternal sickle cell disease. Effects on blood rheology and uteroplacental Doppler velocimetry
RJ Howard, SM Tuck, T Pearson
Clinical & Laboratory Haematology 1994
Mandibular nerve neuropathy in sickle cell disease
G Gregory, A Olujohungbe
Oral Surgery, Oral Medicine, Oral Pathology 1994
Physicochemical Methods in the Study of Biomembranes
HJ Hilderson, GB Ralston
1994
Disorders of Blood Viscosity
T Somer, HJ Meiselman
Annals of Medicine 1993
Is “Relative” Hypertension a Risk Factor for Vaso-occlusive Complications in Sickle Cell Disease?
GP Rodgers, EC Walker, MJ Podgor
The American Journal of the Medical Sciences 1993
Cation transport and volume regulation in sickle red blood cells
CH Joiner
American journal of physiology. Cell physiology 1993
α- and β-haemoglobin chain induced changes in normal erythrocyte deformability: comparison to β thalassaemia intermedia and Hb H disease
MD Scott, P Rouyer-Fessard, MS Ba, BH Lubin, Y Beuzard
British Journal of Haematology 1992
Influence of sickle hemoglobin polymerization and membrane properties on deformability of sickle erythrocytes in the microcirculation
C Dong, RS Chadwick, AN Schechter
Biophysical Journal 1992
Alterations in Erythrocyte Rheology in Patients with Severe Peripheral Vascular Disease: 1. Cell Volume Dependence of Erythrocyte Rigidity
TC Hung, S Pham, DL Steed, MW Webster, DB Butter
Angiology 1991
Interfaces in Medicine and Mechanics—2
KR Williams, A Toni, J Middleton, G Pallotti
1991
Field-cycling relaxometry of protein solutions and tissue: Implications for MRI
SH Koenig, RD Brown
Progress in Nuclear Magnetic Resonance Spectroscopy 1990
Red cell deformability and haematological disorders
J Stuart, GB Nash
Blood Reviews 1990
Dynamics of oxygen unloading from sickle erythrocytes
VB Makhijani, GR Cokelet, A Clark
Biophysical Journal 1990
The effect of malonyldialdehyde on viscosity of normal and sickle red blood cells
SK Jain, JD Ross, GJ Levy, J Duett
Biochemical Medicine and Metabolic Biology 1990
Direct measurement of the internal viscosity of sickle erythrocytes as a function of cell density
PD Morse, JA Warth
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1990
Rheological and Adherence Properties of Sickle Cells
N Mohandas, E Evans
Annals of the New York Academy of Sciences 1989
RHEOLOGICAL CONSEQUENCES OF ERYTHROCYTE DEHYDRATION
J Stuart, JC Ellory
British Journal of Haematology 1988
Intravital microscopy of capillary hemodynamics in sickle cell disease
HH Lipowsky, NU Sheikh, DM Katz
Journal of Clinical Investigation 1987
The time course of filtration test as a model for microvascular plugging by white cells and hardened red cells
WH Reinhart, S Chien
Microvascular Research 1987
The development of a filtration system for evaluating flow characteristics of erythrocytes
C Acquaye, EC Walker, AN Schechter
Microvascular Research 1987
6 Rheology of the sickle cell disorders
J Stuart, CS Johnson
Baillière's Clinical Haematology 1987
1 Blood rheology in vitro and in vivo
GD Lowe
Baillière's Clinical Haematology 1987
Enzyme kinetics in solvents of increased viscosity. Dynamics aspects of carbonic anhydrase catalysis
Y Pocker, N Janjic
Biochemistry 1987
Clinical Disorders of Membrane Transport Processes
TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz
1987
Lateral mobility of a lipid analog in the membrane of irreversible sickle erythrocytes
JA Boullier, BA Brown, JC Bush, BG Barisas
Biochimica et Biophysica Acta (BBA) - Biomembranes 1986
Acute renal infarction in sickle cell disease
J Granfortuna, K Zamkoff, E Urrutia
American Journal of Hematology 1986
Blood Rheology and Oxygen Transport
D Mathews, P LaSala, S Chien
IEEE Engineering in Medicine and Biology Magazine 1986
Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes
RS Schwartz, Y Tanaka, IJ Fidler, DT Chiu, B Lubin, AJ Schroit
Journal of Clinical Investigation 1985
The microcirculatory society Eugene M. Landis award lecture
S Chien
Microvascular Research 1985
Vascular occlusion and infarction in sickle cell crisis and the sickle chest syndrome
NA Athanasou, C Hatton, JO McGee, DJ Weatherall
Journal of clinical pathology 1985
Blood Filtration and Blood Cell Deformability
J Dormandy
1985
Concurrent sickle cell anemia and alpha-thalassemia. Effect on pathological properties of sickle erythrocytes
SH Embury, MR Clark, G Monroy, N Mohandas
Journal of Clinical Investigation 1984
Static and dynamic rigidities of normal and sickle erythrocytes. Major influence of cell hemoglobin concentration
E Evans, N Mohandas, A Leung
Journal of Clinical Investigation 1984
Spin-label studies of erythrocyte deformability. IV. Relation of electron spin resonance spectral change with deformation and orientation of erythrocytes in shear flow
S Noji, H Kon, S Taniguchi
Biophysical Journal 1984
Centrifugation of normal and rheumatoid arthritis blood on Ficoll-Hypaque and Ficoll-Nycodenz solutions
DA McCarthy, JD Perry, CM Holburn, AP Kirk, DW James, SR Moore, EJ Holborow
Journal of Immunological Methods 1984
Les paramètres de la rhéologie sanguine: étiologie des syndromes d'hyperviscosité
JF Stoltz, M Lucius
La Revue de Médecine Interne 1984
Molecular association and the viscosity of hemoglobin solutions
M Blank
Journal of Theoretical Biology 1984
9 Transfusion Support for Haemoglobinopathies
TJ Greenwalt, KR Zelenski
Clinics in Haematology 1984
Interaction of phosphatidylserine-phosphatidylcholine liposomes with sickle erythrocytes. Evidence for altered membrane surface properties
RS Schwartz, N Düzgünes, DT Chiu, B Lubin
Journal of Clinical Investigation 1983
Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics
DK Kaul, ME Fabry, P Windisch, S Baez, RL Nagel
Journal of Clinical Investigation 1983
Haemorheological studies of the sickle cell phenomenon in european red deer (Cervus elaphus)
D Seiffge
Blut 1983
YIELD STRESS IN SEDIMENTED RED BLOOD CELL LAYERS
PL Blackshear, DC Deetz, C Morris, SJ Kayser
Annals of the New York Academy of Sciences 1983
Current Topics in Membranes and Transport
J Gliemann, WD Rees
Current Topics in Membranes and Transport 1983
Haemorheological studies of the sickle cell phenomenon in european red deer (Cervus elaphus)
D Seiffge
Blut Zeitschrift für die Gesamte Blutforschung 1983
Motion of a tank-treading ellipsoidal particle in a shear flow
SR Keller, R Skalak
Journal of Fluid Mechanics 1982
Concurrent Sickle-Cell Anemia and α-Thalassemia: Effect on Severity of Anemia
SH Embury, AM Dozy, J Miller, JR Davis, KM Kleman, H Preisler, E Vichinsky, WN Lande, BH Lubin, YW Kan, WC Mentzer
New England Journal of Medicine 1982
Sickle cell anemia as a rheologic disease
MD Horne
The American Journal of Medicine 1981
The Molecular Basis of Mutant Hemoglobin Dysfunction
DR Harkness
The Molecular Basis of Mutant Hemoglobin Dysfunction 1981
Decreased viscosity of human erythrocyte suspension induced by chlorpromazine and isoxsuprine
T Suda, D Shimizu, N Maeda, T Shiga
Biochemical Pharmacology 1981
Blood viscosity after splenectomy
DA Robertson, FG Simpson, MS Losowsky
BMJ : British Medical Journal 1981
Clinical Aspects of Blood Viscosity and Cell Deformability
GD Lowe, JC Barbenel, CD Forbes
1981
Normale und Pathologische Physiologie der Haut III / Normal and Pathologic Physiology of the Skin III
WG Forssmann, GJ Jongh, JW Mali, DA Reay, H Schaefer, G Stüttgen, FA Thiele, A Zesch, G Stüttgen, HW Spier, E Schwarz
1981
Deformability of oxygenated irreversibly sickled cells
MR Clark, N Mohandas, SB Shohet
Journal of Clinical Investigation 1980
Lack of influence of fetal hemoglobin levels or erythrocyte indices on the severity of sickle cell anemia
DR Powars, WA Schroeder, JN Weiss, LS Chan, SP Azen
Journal of Clinical Investigation 1980
Analysis of factors regulating erythrocyte deformability
N Mohandas, MR Clark, MS Jacobs, SB Shohet
Journal of Clinical Investigation 1980
Plasma viscosity in sickle-cell anaemia
AA Laogun, NO Ajayi, NO Osamo, LA Okafor
Clinical Physics and Physiological Measurement 1980
Organizational differences in the membrane proteins of normal and irreversibly sickled erythrocytes
RW Rubin, C Milikowski, GE Wise
Biochimica et Biophysica Acta (BBA) - Biomembranes 1980
Voltage pulsation of sickle erythrocytes enhances membrane permeability to oxygen
M Kaibara, TY Tsong
Biochimica et Biophysica Acta (BBA) - Biomembranes 1980
On the energy dissipation in a tank-treading human red blood cell
TM Fischer
Biophysical Journal 1980
The flow of sickle-cell blood in the capillaries
SA Berger, WS King
Biophysical Journal 1980
The kinetics of sickle blood viscosity changes following rapid deoxygenation and reoxygenation
RJ Roselli, I Fatt
Microvascular Research 1980
Blood rheology
J Stuart, MW Kenny
Journal of clinical pathology 1980
Biofluid Mechanics · 2
DJ Schneck
1980
Methods in Angiology
M Verstraete
1980
Serial Changes in Coagulation and Viscosity during Sickle-Cell Crisis
SG Richardson, KB Matthews, J Stuart, AM Geddes, RM Wilcox
British Journal of Haematology 1979
Variability of Intracellular pH within Individual Populations of SS and AA Erythrocytes
AA Kaperonis, JF Bertles, S Chien
British Journal of Haematology 1979
Rheological Properties of Blood at Rest and After Ischemia and Exercise
V Bartoli, G Moradei, MG Peluso, V Lapini, M Cipriani
Vascular and endovascular surgery 1979
Monovalent cation transport in irreversibly sickled cells
MR Clark, CE Morrison, SB Shohet
Journal of Clinical Investigation 1978
LEG ULCERATION AND HAEMOLYTIC ANAEMIA: AN HYPOTHESIS
RD Peachey
British Journal of Dermatology 1978
Membrane alterations in irreversibly sickled cells: Hemoglobin-membrane interaction
LS Lessin, J Kurantsin-Mills, C Wallas, H Weems
Journal of Supramolecular Structure 1978
Deformability characteristics of sickle cells by microelastimetry
TC Havell, D Hillman, LS Lessin
American Journal of Hematology 1978
Study of irreversibly sickled cells in an animal model
O Castro, JD Cochran
Journal of the National Medical Association 1978
Studies on the altered membrane characteristics of sickle cells
C Rice-Evans, KR Bruckdorfer, G Dootson
FEBS Letters 1978
Biochemical and Clinical Aspects of Hemoglobin Abnormalities
HS Ballard
Biochemical and Clinical Aspects of Hemoglobin Abnormalities 1978
Red Cell Rheology
M Bessis, SB Shohet, N Mohandas
1978
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil
1978
RED CELL MEMBRANE INJURY IN SICKLE CELL ANAEMIA
J Palek
British Journal of Haematology 1977
Differences in erythrocyte membrane proteins and glycoproteins in sickle cell disease
MG Riggs, VM Ingram
Biochemical and Biophysical Research Communications 1977
Hard quasispherical model for the viscosity of hemoglobin solutions
PD Ross, AP Minton
Biochemical and Biophysical Research Communications 1977
Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells
SE Lux, KM John, MJ Karnovsky
Journal of Clinical Investigation 1976
Increased Whole Blood Viscosity on Cooling in a Patient with Cold Hemoagglutinin Disease
A Girolami, G Cella, G Patrassi
Vox Sanguinis 1976
Altered erythrocyte membrane phosphorylation in sickle cell disease
MM Hosey, M Tao
Nature 1976
Intermolecular interactions of oxygenated sickle hemoglobin molecules in cells and cell-free solutions
TR Lindstrom, SH Koenig, T Boussios, JF Bertles
Biophysical Journal 1976
Hyperfibrinogenaemia and hyperviscosity in sickle-cell crisis
SG Richardson, GR Breeze, J Stuart
Journal of clinical pathology 1976
Hemolytic Anemias: Failure of the Red Cell Membrane
SB Shohet, PM Ness
Medical Clinics of North America 1976
A concentrated suspension model for the couette rheology of blood
C Brennen
The Canadian Journal of Chemical Engineering 1975
Effect of deoxygenation on blood rheology in sickle cell disease
S Usami, S Chien, PM Scholtz, JF Bertles
Microvascular Research 1975
Multiple myeloma in a patient with sickle cell anemia
IS Anderson, KY Yeung, D Hillman, LS Lessin
The American Journal of Medicine 1975
Fetal Haemoglobin in Homozygous Sickle Cell Disease
GR Serjeant
Clinics in Haematology 1975
HUMAN FETAL HEMOGLOBIN: SIGNIFICANCE IN DISEASE
JF Bertles
Annals of the New York Academy of Sciences 1974
Kinetics of oxygenation and deoxygenation of erythrocytes containing hemoglobin S
HH Rotman, RA Klocke, KK Andersson, L D'Alecy, RE Forster
Respiration Physiology 1974
The Red Blood Cell
GJ Brewer
The Red Blood Cell 1974
Determination of the Minimum Gelling Concentration as a Measure of Sickling Tendency
RM Bookchin
Critical Reviews in Clinical Laboratory Sciences 1974
Erythrocyte Hb-S Concentration AN IMPORTANT FACTOR IN THE LOW OXYGEN AFFINITY OF BLOOD IN SICKLE CELL ANEMIA
M Seakins, WN Gibbs, PF Milner, JF Bertles
Journal of Clinical Investigation 1973
Life Span of Carbamylated Red Cells in Sickle Cell Anemia
PF Milner, S Charache
Journal of Clinical Investigation 1973
Neurohumoral and Metabolic Aspects of Injury
AG Kovách, HB Stoner, JJ Spitzer
1973
Impairment of Red Cell Transit through the Canine Lungs following Injections of Hypertonic Fluids
RM Effros
Circulation research 1972
Alteration in the rheologic properties of plasmodium knowlesi-infected red cells. A possible mechanism for capillary obstruction
LH Miller, S Usami, S Chien
Journal of Clinical Investigation 1971
Viscosity of turkey blood: Rheology of nucleated erythrocytes
S Usami, V Magazinovic, S Chien, MI Gregersen
Microvascular Research 1970
Hemoglobin O Arab in Four Negro Families and Its Interaction with Hemoglobin S and Hemoglobin C
PF Milner, C Miller, R Grey, M Seakins, WW DeJong, LN Went
New England Journal of Medicine 1970
Sickle Cell Anemia
GW James, WB Porter
Postgraduate Medicine 1952

← Previous 1 2 … 8 9 10 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 1 X users
107 readers on Mendeley
See more details