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Research Article Free access | 10.1172/JCI106237

Increased Vascular permeability produced by human platelet granule cationic extract

Ralph L. Nachman, Babette Weksler, and Barbara Ferris

1Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021

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1Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021

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1Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021

Find articles by Ferris, B. in: JCI | PubMed | Google Scholar

Published February 1, 1970 - More info

Published in Volume 49, Issue 2 on February 1, 1970
J Clin Invest. 1970;49(2):274–281. https://doi.org/10.1172/JCI106237.
© 1970 The American Society for Clinical Investigation
Published February 1, 1970 - Version history
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Abstract

A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.

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