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Research Article Free access | 10.1172/JCI106228

Ferrokinetics: a biologic model for plasma iron exchange in man

J. D. Cook, G. Marsaglia, J. W. Eschbach, D. D. Funk, and C. A. Finch

1Department of Medicine, University of Washington School of Medicine, the Boeing Scientific Research Laboratories, and the U. S. Public Health Service Hospital, Seattle, Washington 98105

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1Department of Medicine, University of Washington School of Medicine, the Boeing Scientific Research Laboratories, and the U. S. Public Health Service Hospital, Seattle, Washington 98105

Find articles by Marsaglia, G. in: JCI | PubMed | Google Scholar

1Department of Medicine, University of Washington School of Medicine, the Boeing Scientific Research Laboratories, and the U. S. Public Health Service Hospital, Seattle, Washington 98105

Find articles by Eschbach, J. in: JCI | PubMed | Google Scholar

1Department of Medicine, University of Washington School of Medicine, the Boeing Scientific Research Laboratories, and the U. S. Public Health Service Hospital, Seattle, Washington 98105

Find articles by Funk, D. in: JCI | PubMed | Google Scholar

1Department of Medicine, University of Washington School of Medicine, the Boeing Scientific Research Laboratories, and the U. S. Public Health Service Hospital, Seattle, Washington 98105

Find articles by Finch, C. in: JCI | PubMed | Google Scholar

Published February 1, 1970 - More info

Published in Volume 49, Issue 2 on February 1, 1970
J Clin Invest. 1970;49(2):197–205. https://doi.org/10.1172/JCI106228.
© 1970 The American Society for Clinical Investigation
Published February 1, 1970 - Version history
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Abstract

A method is presented for calculating internal iron kinetics. An early reflux associated with extravascular exchange and a late reflux associated with erythropoiesis are described. A biologic model of iron exchange is proposed in which erythron iron turnover is divided into an effective portion (iron fixed in circulating red cells) and wastage iron of erythropoiesis (late reflux). Nonerythroid iron exchange also has a fixed portion (parenchymal uptake) and an early reflux (lymphatic circuit), both of which correlate in amount with the amount of plasma iron. Ferrokinetic measurements in normal subjects and in various pathologic states are presented to validate the model.

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