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Research Article Free access | 10.1172/JCI106202
Department of Medicine, University of Rochester School of Medicine and Dentistry, University of Rochester College of Arts and Sciences, Rochester, New York 14620
Department of Statistics, University of Rochester College of Arts and Sciences, Rochester, New York 14620
Find articles by Waterhouse, C. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Rochester School of Medicine and Dentistry, University of Rochester College of Arts and Sciences, Rochester, New York 14620
Department of Statistics, University of Rochester College of Arts and Sciences, Rochester, New York 14620
Find articles by Keilson, J. in: JCI | PubMed | Google Scholar
Published December 1, 1969 - More info
12 subjects have been studied after an overnight fast with trace amounts of pyruvate-3-14C and glucose-6-14C. Blood disappearance curves and incorporation of the pyruvate-3-14C label into blood glucose have been determined. By the use of transfer functions which allow processes with many different chemical steps to be examined as a unit, we have determined the per cent of pyruvate and presumably lactate which is regenerated into glucose. 8 of the 12 subjects showed that 7-23 mg/kg per hr are recycled, while 4 subjects fell well outside this range. Correlation of increased activity was not good with any demonstrated metabolic abnormality (diabetes or obesity), and it is suggested from clinical observation of the subjects that anxiety may play a role.