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Research Article Free access | 10.1172/JCI106195

Inheritance of human α1-acid glycoprotein (orosomucoid) variants

A. Myron Johnson, Karl Schmid, and Chester A. Alper

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118

Find articles by Johnson, A. in: PubMed | Google Scholar

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118

Find articles by Schmid, K. in: PubMed | Google Scholar

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118

Find articles by Alper, C. in: PubMed | Google Scholar

Published December 1, 1969 - More info

Published in Volume 48, Issue 12 on December 1, 1969
J Clin Invest. 1969;48(12):2293–2299. https://doi.org/10.1172/JCI106195.
© 1969 The American Society for Clinical Investigation
Published December 1, 1969 - Version history
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Abstract

Although variants of sialic acid-free α1-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of α1-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes α1-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.

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