Advertisement
Research Article Free access | 10.1172/JCI106195
Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115
Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118
Find articles by Johnson, A. in: PubMed | Google Scholar
Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115
Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118
Find articles by Schmid, K. in: PubMed | Google Scholar
Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115
Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts 02118
Find articles by Alper, C. in: PubMed | Google Scholar
Published December 1, 1969 - More info
Although variants of sialic acid-free α1-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of α1-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes α1-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.
Images.