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Research Article Free access | 10.1172/JCI106081

The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum

Edward M. Scott, Rita C. Wright, and David D. Weaver

1Arctic Health Research Center, U. S. Public Health Service, College, Alaska 99701

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1Arctic Health Research Center, U. S. Public Health Service, College, Alaska 99701

Find articles by Wright, R. in: PubMed | Google Scholar

1Arctic Health Research Center, U. S. Public Health Service, College, Alaska 99701

Find articles by Weaver, D. in: PubMed | Google Scholar

Published July 1, 1969 - More info

Published in Volume 48, Issue 7 on July 1, 1969
J Clin Invest. 1969;48(7):1173–1176. https://doi.org/10.1172/JCI106081.
© 1969 The American Society for Clinical Investigation
Published July 1, 1969 - Version history
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Abstract

Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130.

Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators.

The gene frequency for slow inactivation was 0.46 ±0.04 in Alaskan Eskimos and 0.62±0.06 in Athabaskan Indians.

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