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Free access | 10.1172/JCI106064

Heterogeneity of human platelets: II. Functional evidence suggestive of young and old platelets

Simon Karpatkin

1Department of Medicine, New York University Medical Center, New York 10016

Find articles by Karpatkin, S. in: JCI | PubMed | Google Scholar

Published June 1, 1969 - More info

Published in Volume 48, Issue 6 on June 1, 1969
J Clin Invest. 1969;48(6):1083–1087. https://doi.org/10.1172/JCI106064.
© 1969 The American Society for Clinical Investigation
Published June 1, 1969 - Version history
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Abstract

In the previous communication, suggestive evidence was presented for large-heavy platelets being “young” platelets and light-small platelets being “old” platelets. Large-heavy, light-small, and total human platelet populations were compared with respect to their platelet function. After addition of adenosine diphosphate (ADP), thrombin, or epinephrine, platelet aggregation time was 3.0-, 4.5-, and 3.3-fold shorter with large-heavy platelets compared with light-small platelets, and large-heavy platelets released 3.7-, 7.6-, and 8.1-fold greater adenosine triphosphate (ATP) into the medium, respectively, than did light-small platelets. After platelet aggregation by thrombin or epinephrine, large-heavy platelets released 6.0- and 3.8-fold more ADP into the medium than did light-small platelets. After platelet aggregation by ADP, light-small platelets consumed 5.9-fold greater added extracellular ADP than did large-heavy platelets.

Large-heavy platelets aggregated by ADP, thrombin, or epinephrine released 9.1-, 8.5-, and 12.7-fold greater platelet factor 4 than light-small platelets similarly treated.

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