Effects of triiodothyronine-induced hypermetabolism on factor VIII and fibrinogen in man

John C. Hoak; William R. Wilson; Emory D. Warner; Ernest O. Theilen; Glenna L. Fry; Fred L. Benoit

doi:10.1172/JCI106034

^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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^{Blood Coagulation Research Laboratory, Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

^{Blood Coagulation Research Laboratory, Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa 52240}

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Published in Volume 48, Issue 4 on April 1, 1969
J Clin Invest. 1969;48(4):768–774. https://doi.org/10.1172/JCI106034.
© 1969 The American Society for Clinical Investigation

Published April 1, 1969 - Version history

Triiodothyronine (liothyronine sodium) (400-500 μg/day for 14 days) was given to six normal subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < 0.05); fibrinogen increased from 344 to 581 mg/100 ml (P < 0.01). To test whether the increases in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol (20 mg every 6 hr) was given orally to four other normal subjects in addition to triiodothyronine for 14 days. Factor VIII increased from 100 to 161%; fibrinogen increased from 374 to 564% (P < 0.01). Factor VIII activity did not change in a severe classical hemophiliac made hypermetabolic with triiodothyronine, but it increased from 39 to 82% in a patient with von Willebrand's disease. Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-⁷⁵Se into plasma fibrinogen. These results suggest that the increases in clotting factor activity during triiodothyronine-induced hypermetabolism reflect an effect of increased protein synthesis rather than enhanced stimulation of beta adrenergic receptors.

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Effects of triiodothyronine-induced hypermetabolism on factor VIII and fibrinogen in man

John C. Hoak, William R. Wilson, Emory D. Warner, Ernest O. Theilen, Glenna L. Fry, and Fred L. Benoit

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Effects of triiodothyronine-induced hypermetabolism on factor VIII and fibrinogen in man

John C. Hoak, William R. Wilson, Emory D. Warner, Ernest O. Theilen, Glenna L. Fry, and Fred L. Benoit

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