The conversion of testosterone-1,2-3H to dihydrotestosterone by slices of human skin obtained from various anatomical sites in 112 normal subjects and three individuals with the syndrome of testicular feminization has been measured under standardized conditions. Very low rates of dihydrotestosterone formation were observed in sites obtained from the mons or from miscellaneous areas of the trunk and limbs of the control subjects. The mean rates of conversion were very high, however, in slices of skin obtained from several perineal sites (labia majora, scrotum, prepuce, and clitoris). Furthermore, as measured here, the rate of dihydrotestosterone formation by prepuce rises during the 3 months after birth and then falls progressively thereafter, reaching a level in the adult that is almost as low as that observed in the slices of nonperineal skin from all ages. In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects.
Jean D. Wilson, Joanne D. Walker
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I Takashima |
The Journal of Dermatology | 1974 |
In Vitro Biotransformation of Steroid Hormones by Human Semen**Supported in part by Ford Foundation Grant No. 650-0252B. Dr. Castañeda’s present address is: The Ben May Laboratory, University of Chicago. Dr. Iramain’s present address is: Department of Cell Biology, Baylor College of Medicine, Houston
E Castañeda, EP Rios, AE Perez, R Lichtenberg, C Cordero, CA Iramain, G Perez-Palacios |
Fertility and Sterility | 1974 |
Primary and Secondary Amenorrhoea
C Dewhurst |
1974 | |
Plasma testosterone and androstenedione after orchiectomy in prostatic adenocarcinoma
F Sciarra, G Sorcini, F Silverio, V Gagliardi |
Clinical Endocrinology | 1973 |
SKIN BIOPSY SITE AND BIOLOGY OF FIBROBLAST STRAINS
M Kaufman, L Pinsky |
The Lancet | 1973 |
HIRSUTISM. A REVIEW OF THE GENETIC AND EXPERIMENTAL ASPECTS
SA Muller |
Journal of Investigative Dermatology | 1973 |
Permanent Effects of Foetal and Neonatal Testosterone Secretion on Steroid Metabolism and Binding
P Moor, G Verhoeven, W Heyns |
Differentiation | 1973 |
Proceedings of the 1972 Laurentian Hormone Conference
E Sims, E Danforth, E Horton, G Bray, J Glennon, L Salans |
Proceedings of the 1972 Laurentian Hormone Conference | 1973 |
The Endocrine Function of the Human Testis
A Vermeulen |
The Endocrine Function of the Human Testis | 1973 |
End organ metabolism of testosterone
T Moshang, AM Bongiovanni |
Journal of Steroid Biochemistry | 1973 |
Determination of serum testosterone and androstanediol by competitive protein binding
AL Strickland, M Apland, J Bruton |
Steroids | 1973 |
Autoradiographische Untersuchungen �ber den Einflu� von Cyproteronacetat auf die epidermale Proliferation der m�nnlichen Ratte
H Schell, GH Schmid |
Archives of Dermatological Research | 1973 |
24. Tagung vom 13. bis 16. September 1972 in Hannover
HK Büscher, R Nagel |
1973 | |
Receptors for Reproductive Hormones
BW OMalley, AR Means |
1973 | |
Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
JM Saez, MG Forest, AM Morera, J Bertrand |
Journal of Clinical Investigation | 1972 |
Metabolism of testosterone-14C by cultured human cells
DD Shanie, K Hirschhorn, MI New |
Journal of Clinical Investigation | 1972 |
Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization
JL Goldstein, JD Wilson |
Journal of Clinical Investigation | 1972 |
METABOLISM OF TESTOSTERONE BY HUMAN BREAST TUMOURS
JS Jenkins, S Ash |
The Lancet | 1972 |
The metabolism of testosterone and dihydrotestosterone in an androgen-dependent tumour. A possible correlation between dihydrotestosterone and tumour growth in vivo
N Bruchovsky |
Biochemical Journal | 1972 |
Quantification of free dihydrotestosterone in blood plasma and tissue
GC Haltmeyer, KB Eik-Nes |
Analytical Biochemistry | 1972 |
Plasma 5α-dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) in adolescent males at different stages of sexual maturation
D Gupta, E McCafferty, K Rager |
Steroids | 1972 |
The response of the cutaneous glands to steroids
FJ Ebling |
General and Comparative Endocrinology | 1972 |
Subcellular localization of the C19-steroid reductase activities of female rat liver
N Arimasa, CD Kochakian |
Steroids | 1972 |
Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors
L Pinsky, R Finkelberg, C Straisfeld, B Zilahi, M Kaufman, G Hall |
Biochemical and Biophysical Research Communications | 1972 |
Testicular Feminization: The Clinical Features, Endocrine Function and Gonadal Pathology in Six Patients
SK Khoo, EV Mackay |
The Australian and New Zealand Journal of Obstetrics and Gynaecology | 1972 |
Genetic studies in a family with testicular feminization, haemophilia A and colour blindness
L Holmberg |
Clinical Genetics | 1972 |
The Syndrome of Testicular Feminization
G Perez-Palacios, RB Jaffe |
Pediatric Clinics of North America | 1972 |
Hirsutism and anovulatory infertility
RV Brooks |
Postgraduate medical journal | 1972 |
Sexualhormonabhängige Gehirndifferenzierung und Sexualität
G Dörner |
1972 | |
Binding of Steroid Hormones by the 105,000 x g Supernatant Fraction from Homogenates of Rat Skin and Variations during the Hair Cycle
U Eppenberger, SL Hsia |
The Journal of biological chemistry | 1972 |
The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols
JA Mahoudeau, CW Bardin, MB Lipsett |
Journal of Clinical Investigation | 1971 |
The Source of Plasma Dihydrotestosterone in Man
T Ito, R Horton |
Journal of Clinical Investigation | 1971 |
GONADAL MALIGNANCY IN XY FEMALES
CJ Dewhurst, HP Ferreira, PG Gillett |
BJOG: An International Journal of Obstetrics and Gynaecology | 1971 |
DIFFERENTIALRATES OF CONVERSION OF TESTERONE TO DIHYDROTESTOSTERONE IN ACNE AND IN NORMAL HUMAN SKIN- A POSSIBLE PATHOGENIC FACTOR IN ACNE
G Sansone, RM Reisner |
Journal of Investigative Dermatology | 1971 |
Research on Steroids
O Crepy, J Gueriguian |
Research on Steroids | 1971 |
Screening Methods in Pharmacology
HJ Wilkens, R Steger |
Screening Methods in Pharmacology | 1971 |
Determination of testosterone in human urine by means of horizontal thin-layer and gas-liquid chromatography
M Luisi, C Fassorra, C Levanti, F Franchi |
Journal of Chromatography A | 1971 |
Anabolic effect of dihydrotestosterone in testicular feminization syndrome
CR Hamilton, B Kliman |
Metabolism | 1971 |
In vitro metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulphate in breast skin of women
MB Hodgins |
Steroids | 1971 |
Biochemical studies on the incomplete form of testicular feminization syndrome
G Pérez-Palacios, T Morato, AE Pérez, E Castañeda, C Gual |
Steroids | 1971 |
The XY female
CJ Dewhurst |
American Journal of Obstetrics and Gynecology | 1971 |
Metabolic studies in a patient with testicular feminization syndrome
E Castañeda, AE Perez, MA Guillen, S Ramirez-Robles, C Gual, G Pérez-Palacios |
American Journal of Obstetrics and Gynecology | 1971 |
Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes
J Kracht |
1971 | |
Partial Characterization of the Nuclear Reduced Nicotinamide Adenine Dinucleotide Phosphate: Δ4-3-Ketosteroid 5α-Oxidoreductase of Rat Prostate
DW Frederiksen, JD Wilson |
The Journal of biological chemistry | 1971 |
Androgen Metabolism in Human Skin
IF Sommerville, WP Collins, C Flamigni, EN Koullapis, CJ Dewhurst |
Proceedings of the Royal Society of Medicine | 1971 |
Vierundzwanzigste Österreichische Ärztetagung Wien Van-Swieten-Kongreß: 19. Oktober bis 24. Oktober 1970
G Harrer |
1971 | |
Studies on testosterone metabolism in subjects with testicular feminization syndrome
P Mauvais-Jarvis, JP Bercovici, O Crepy, F Gauthier |
Journal of Clinical Investigation | 1970 |
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson |
Journal of Clinical Investigation | 1970 |
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson |
Journal of Clinical Investigation | 1970 |
Testosterone
DW Killinger |
Canadian Medical Association journal | 1970 |
Skin collagen and thickness in women with hirsuties
S Shuster, MM Black, E Bottoms |
British medical journal | 1970 |
Proceedings of the 1969 Laurentian Hormone Conference
K Sterling |
Proceedings of the 1969 Laurentian Hormone Conference | 1970 |
5α-steroid reductase activity in tissues from rats with end organ insensitivity to testosterone
L Bullock, G Schneider, CW Bardin |
Life Sciences | 1970 |
Metabolism of radioactive 5α-androstane-3β, 17β-diol
P Mauvais-Jarvis, S Guillemant, P Corvol, HH Floch, L Bardou |
Steroids | 1970 |
Syndromes of Testicular Feminization: An Informal Appraisal and Review of the Latest Advances in Insights, with Special Emphasis on Pathogenesis, Biochemical Mechanisms at Work and Psychosocial Clinical Problems
RD Adams, B Kliman, DD Federman, HS Ulfelder, LB Holmes |
Clinical Pediatrics | 1970 |
The Human Testis
E Rosemberg, CA Paulsen |
1970 | |
Mammalian Reproduction
H Gibian, EJ Plotz |
1970 | |
Transformation of Testosterone into 17β-Hydroxy-5α-androstan-3-one by Microsomal Preparations of Human Skin
W Voigt, EP Fernandez, SL Hsia |
The Journal of biological chemistry | 1970 |
Intranuclear Metabolism of Progesterone-1,2-3H in the Hen Oviduct
MD Morgan, JD Wilson |
The Journal of biological chemistry | 1970 |
Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis
RB Jaffe |
Steroids | 1969 |
Receptor Proteins for Androgens
S Fang, KM Anderson, S Liao |
The Journal of biological chemistry | 1969 |
Advances in Lipid Research
AM Scanu |
Advances in Lipid Research | 1965 |
The role of pre-operative androgen stimulation in hypospadias surgery
Cevdet Kaya, Christian Radmayr |
Translational andrology and urology |