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The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man
Jean D. Wilson, Joanne D. Walker
Jean D. Wilson, Joanne D. Walker
Published February 1, 1969
Citation Information: J Clin Invest. 1969;48(2):371-379. https://doi.org/10.1172/JCI105994.
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The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man

Abstract

The conversion of testosterone-1,2-3H to dihydrotestosterone by slices of human skin obtained from various anatomical sites in 112 normal subjects and three individuals with the syndrome of testicular feminization has been measured under standardized conditions. Very low rates of dihydrotestosterone formation were observed in sites obtained from the mons or from miscellaneous areas of the trunk and limbs of the control subjects. The mean rates of conversion were very high, however, in slices of skin obtained from several perineal sites (labia majora, scrotum, prepuce, and clitoris). Furthermore, as measured here, the rate of dihydrotestosterone formation by prepuce rises during the 3 months after birth and then falls progressively thereafter, reaching a level in the adult that is almost as low as that observed in the slices of nonperineal skin from all ages. In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects.

Authors

Jean D. Wilson, Joanne D. Walker

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AL Strickland, M Apland, J Bruton 		Steroids 1973
Autoradiographische Untersuchungen �ber den Einflu� von Cyproteronacetat auf die epidermale Proliferation der m�nnlichen Ratte
H Schell, GH Schmid 		Archives of Dermatological Research 1973
24. Tagung vom 13. bis 16. September 1972 in Hannover
HK Büscher, R Nagel 		1973
Receptors for Reproductive Hormones
BW OMalley, AR Means 		1973
Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
JM Saez, MG Forest, AM Morera, J Bertrand 		Journal of Clinical Investigation 1972
Metabolism of testosterone-14C by cultured human cells
DD Shanie, K Hirschhorn, MI New 		Journal of Clinical Investigation 1972
Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization
JL Goldstein, JD Wilson 		Journal of Clinical Investigation 1972
METABOLISM OF TESTOSTERONE BY HUMAN BREAST TUMOURS
JS Jenkins, S Ash 		The Lancet 1972
The metabolism of testosterone and dihydrotestosterone in an androgen-dependent tumour. A possible correlation between dihydrotestosterone and tumour growth in vivo
N Bruchovsky 		Biochemical Journal 1972
Quantification of free dihydrotestosterone in blood plasma and tissue
GC Haltmeyer, KB Eik-Nes 		Analytical Biochemistry 1972
Plasma 5α-dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) in adolescent males at different stages of sexual maturation
D Gupta, E McCafferty, K Rager 		Steroids 1972
The response of the cutaneous glands to steroids
FJ Ebling 		General and Comparative Endocrinology 1972
Subcellular localization of the C19-steroid reductase activities of female rat liver
N Arimasa, CD Kochakian 		Steroids 1972
Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors
L Pinsky, R Finkelberg, C Straisfeld, B Zilahi, M Kaufman, G Hall 		Biochemical and Biophysical Research Communications 1972
Testicular Feminization: The Clinical Features, Endocrine Function and Gonadal Pathology in Six Patients
SK Khoo, EV Mackay 		The Australian and New Zealand Journal of Obstetrics and Gynaecology 1972
Genetic studies in a family with testicular feminization, haemophilia A and colour blindness
L Holmberg 		Clinical Genetics 1972
The Syndrome of Testicular Feminization
G Perez-Palacios, RB Jaffe 		Pediatric Clinics of North America 1972
Hirsutism and anovulatory infertility
RV Brooks 		Postgraduate medical journal 1972
Sexualhormonabhängige Gehirndifferenzierung und Sexualität
G Dörner 		1972
Binding of Steroid Hormones by the 105,000 x g Supernatant Fraction from Homogenates of Rat Skin and Variations during the Hair Cycle
U Eppenberger, SL Hsia 		The Journal of biological chemistry 1972
The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols
JA Mahoudeau, CW Bardin, MB Lipsett 		Journal of Clinical Investigation 1971
The Source of Plasma Dihydrotestosterone in Man
T Ito, R Horton 		Journal of Clinical Investigation 1971
GONADAL MALIGNANCY IN XY FEMALES
CJ Dewhurst, HP Ferreira, PG Gillett 		BJOG: An International Journal of Obstetrics and Gynaecology 1971
DIFFERENTIALRATES OF CONVERSION OF TESTERONE TO DIHYDROTESTOSTERONE IN ACNE AND IN NORMAL HUMAN SKIN- A POSSIBLE PATHOGENIC FACTOR IN ACNE
G Sansone, RM Reisner 		Journal of Investigative Dermatology 1971
Research on Steroids
O Crepy, J Gueriguian 		Research on Steroids 1971
Screening Methods in Pharmacology
HJ Wilkens, R Steger 		Screening Methods in Pharmacology 1971
Determination of testosterone in human urine by means of horizontal thin-layer and gas-liquid chromatography
M Luisi, C Fassorra, C Levanti, F Franchi 		Journal of Chromatography A 1971
Anabolic effect of dihydrotestosterone in testicular feminization syndrome
CR Hamilton, B Kliman 		Metabolism 1971
In vitro metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulphate in breast skin of women
MB Hodgins 		Steroids 1971
Biochemical studies on the incomplete form of testicular feminization syndrome
G Pérez-Palacios, T Morato, AE Pérez, E Castañeda, C Gual 		Steroids 1971
The XY female
CJ Dewhurst 		American Journal of Obstetrics and Gynecology 1971
Metabolic studies in a patient with testicular feminization syndrome
E Castañeda, AE Perez, MA Guillen, S Ramirez-Robles, C Gual, G Pérez-Palacios 		American Journal of Obstetrics and Gynecology 1971
Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes
J Kracht 		1971
Partial Characterization of the Nuclear Reduced Nicotinamide Adenine Dinucleotide Phosphate: Δ4-3-Ketosteroid 5α-Oxidoreductase of Rat Prostate
DW Frederiksen, JD Wilson 		The Journal of biological chemistry 1971
Androgen Metabolism in Human Skin
IF Sommerville, WP Collins, C Flamigni, EN Koullapis, CJ Dewhurst 		Proceedings of the Royal Society of Medicine 1971
Vierundzwanzigste Österreichische Ärztetagung Wien Van-Swieten-Kongreß: 19. Oktober bis 24. Oktober 1970
G Harrer 		1971
Studies on testosterone metabolism in subjects with testicular feminization syndrome
P Mauvais-Jarvis, JP Bercovici, O Crepy, F Gauthier 		Journal of Clinical Investigation 1970
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson 		Journal of Clinical Investigation 1970
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson 		Journal of Clinical Investigation 1970
Testosterone
DW Killinger 		Canadian Medical Association journal 1970
Skin collagen and thickness in women with hirsuties
S Shuster, MM Black, E Bottoms 		British medical journal 1970
Proceedings of the 1969 Laurentian Hormone Conference
K Sterling 		Proceedings of the 1969 Laurentian Hormone Conference 1970
5α-steroid reductase activity in tissues from rats with end organ insensitivity to testosterone
L Bullock, G Schneider, CW Bardin 		Life Sciences 1970
Metabolism of radioactive 5α-androstane-3β, 17β-diol
P Mauvais-Jarvis, S Guillemant, P Corvol, HH Floch, L Bardou 		Steroids 1970
Syndromes of Testicular Feminization: An Informal Appraisal and Review of the Latest Advances in Insights, with Special Emphasis on Pathogenesis, Biochemical Mechanisms at Work and Psychosocial Clinical Problems
RD Adams, B Kliman, DD Federman, HS Ulfelder, LB Holmes 		Clinical Pediatrics 1970
The Human Testis
E Rosemberg, CA Paulsen 		1970
Mammalian Reproduction
H Gibian, EJ Plotz 		1970
Transformation of Testosterone into 17β-Hydroxy-5α-androstan-3-one by Microsomal Preparations of Human Skin
W Voigt, EP Fernandez, SL Hsia 		The Journal of biological chemistry 1970
Intranuclear Metabolism of Progesterone-1,2-3H in the Hen Oviduct
MD Morgan, JD Wilson 		The Journal of biological chemistry 1970
Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis
RB Jaffe 		Steroids 1969
Receptor Proteins for Androgens
S Fang, KM Anderson, S Liao 		The Journal of biological chemistry 1969
Advances in Lipid Research
AM Scanu 		Advances in Lipid Research 1965
The role of pre-operative androgen stimulation in hypospadias surgery
Cevdet Kaya, Christian Radmayr 		Translational andrology and urology

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