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Citations to this article

The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man
Jean D. Wilson, Joanne D. Walker
Jean D. Wilson, Joanne D. Walker
Published February 1, 1969
Citation Information: J Clin Invest. 1969;48(2):371-379. https://doi.org/10.1172/JCI105994.
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The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man

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Abstract

The conversion of testosterone-1,2-3H to dihydrotestosterone by slices of human skin obtained from various anatomical sites in 112 normal subjects and three individuals with the syndrome of testicular feminization has been measured under standardized conditions. Very low rates of dihydrotestosterone formation were observed in sites obtained from the mons or from miscellaneous areas of the trunk and limbs of the control subjects. The mean rates of conversion were very high, however, in slices of skin obtained from several perineal sites (labia majora, scrotum, prepuce, and clitoris). Furthermore, as measured here, the rate of dihydrotestosterone formation by prepuce rises during the 3 months after birth and then falls progressively thereafter, reaching a level in the adult that is almost as low as that observed in the slices of nonperineal skin from all ages. In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects.

Authors

Jean D. Wilson, Joanne D. Walker

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INHIBITION OF DIHYDROTESTOSTERONE FORMATION: AN EFFECTIVE MEANS OF BLOCKING ANDROGEN ACTION IN HAMSTER SEBACEOUS GLAND
SL Hsia, W Voigt
Journal of Investigative Dermatology 1974
Human male sexual maldevelopment: Teratogenetic classification of monogenic forms
L Pinsky
Teratology 1974
Current Topics in Experimental Endocrinology
M Jutisz, C Tertrin-Clary
Current Topics in Experimental Endocrinology 1974
Steroid–Cell Interactions
R King, W Mainwaring
Steroid–Cell Interactions 1974
STUDIES OF COMMON BALDNESS IN THE STUMP-TAILED MACAQUE: V. REGIONAL DIFFERENCE OF TESTOSTERONE METABOLITES IN THE HAIR FOLLICLES
I Takashima
The Journal of Dermatology 1974
In Vitro Biotransformation of Steroid Hormones by Human Semen**Supported in part by Ford Foundation Grant No. 650-0252B. Dr. Castañeda’s present address is: The Ben May Laboratory, University of Chicago. Dr. Iramain’s present address is: Department of Cell Biology, Baylor College of Medicine, Houston
E Castañeda, EP Rios, AE Perez, R Lichtenberg, C Cordero, CA Iramain, G Perez-Palacios
Fertility and Sterility 1974
Primary and Secondary Amenorrhoea
C Dewhurst
1974
Plasma testosterone and androstenedione after orchiectomy in prostatic adenocarcinoma
F Sciarra, G Sorcini, F Silverio, V Gagliardi
Clinical Endocrinology 1973
SKIN BIOPSY SITE AND BIOLOGY OF FIBROBLAST STRAINS
M Kaufman, L Pinsky
The Lancet 1973
HIRSUTISM. A REVIEW OF THE GENETIC AND EXPERIMENTAL ASPECTS
SA Muller
Journal of Investigative Dermatology 1973
Permanent Effects of Foetal and Neonatal Testosterone Secretion on Steroid Metabolism and Binding
P Moor, G Verhoeven, W Heyns
Differentiation 1973
Proceedings of the 1972 Laurentian Hormone Conference
E Sims, E Danforth, E Horton, G Bray, J Glennon, L Salans
Proceedings of the 1972 Laurentian Hormone Conference 1973
The Endocrine Function of the Human Testis
A Vermeulen
The Endocrine Function of the Human Testis 1973
End organ metabolism of testosterone
T Moshang, AM Bongiovanni
Journal of Steroid Biochemistry 1973
Determination of serum testosterone and androstanediol by competitive protein binding
AL Strickland, M Apland, J Bruton
Steroids 1973
Autoradiographische Untersuchungen �ber den Einflu� von Cyproteronacetat auf die epidermale Proliferation der m�nnlichen Ratte
H Schell, GH Schmid
Archives of Dermatological Research 1973
24. Tagung vom 13. bis 16. September 1972 in Hannover
HK Büscher, R Nagel
1973
Receptors for Reproductive Hormones
BW OMalley, AR Means
1973
Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
JM Saez, MG Forest, AM Morera, J Bertrand
Journal of Clinical Investigation 1972
Metabolism of testosterone-14C by cultured human cells
DD Shanie, K Hirschhorn, MI New
Journal of Clinical Investigation 1972
Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization
JL Goldstein, JD Wilson
Journal of Clinical Investigation 1972
METABOLISM OF TESTOSTERONE BY HUMAN BREAST TUMOURS
JS Jenkins, S Ash
The Lancet 1972
The metabolism of testosterone and dihydrotestosterone in an androgen-dependent tumour. A possible correlation between dihydrotestosterone and tumour growth in vivo
N Bruchovsky
Biochemical Journal 1972
Quantification of free dihydrotestosterone in blood plasma and tissue
GC Haltmeyer, KB Eik-Nes
Analytical Biochemistry 1972
Plasma 5α-dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) in adolescent males at different stages of sexual maturation
D Gupta, E McCafferty, K Rager
Steroids 1972
The response of the cutaneous glands to steroids
FJ Ebling
General and Comparative Endocrinology 1972
Subcellular localization of the C19-steroid reductase activities of female rat liver
N Arimasa, CD Kochakian
Steroids 1972
Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors
L Pinsky, R Finkelberg, C Straisfeld, B Zilahi, M Kaufman, G Hall
Biochemical and Biophysical Research Communications 1972
Testicular Feminization: The Clinical Features, Endocrine Function and Gonadal Pathology in Six Patients
SK Khoo, EV Mackay
The Australian and New Zealand Journal of Obstetrics and Gynaecology 1972
Genetic studies in a family with testicular feminization, haemophilia A and colour blindness
L Holmberg
Clinical Genetics 1972
The Syndrome of Testicular Feminization
G Perez-Palacios, RB Jaffe
Pediatric Clinics of North America 1972
Hirsutism and anovulatory infertility
RV Brooks
Postgraduate medical journal 1972
Sexualhormonabhängige Gehirndifferenzierung und Sexualität
G Dörner
1972
Binding of Steroid Hormones by the 105,000 x g Supernatant Fraction from Homogenates of Rat Skin and Variations during the Hair Cycle
U Eppenberger, SL Hsia
The Journal of biological chemistry 1972
The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols
JA Mahoudeau, CW Bardin, MB Lipsett
Journal of Clinical Investigation 1971
The Source of Plasma Dihydrotestosterone in Man
T Ito, R Horton
Journal of Clinical Investigation 1971
GONADAL MALIGNANCY IN XY FEMALES
CJ Dewhurst, HP Ferreira, PG Gillett
BJOG: An International Journal of Obstetrics and Gynaecology 1971
DIFFERENTIALRATES OF CONVERSION OF TESTERONE TO DIHYDROTESTOSTERONE IN ACNE AND IN NORMAL HUMAN SKIN- A POSSIBLE PATHOGENIC FACTOR IN ACNE
G Sansone, RM Reisner
Journal of Investigative Dermatology 1971
Research on Steroids
O Crepy, J Gueriguian
Research on Steroids 1971
Screening Methods in Pharmacology
HJ Wilkens, R Steger
Screening Methods in Pharmacology 1971
Determination of testosterone in human urine by means of horizontal thin-layer and gas-liquid chromatography
M Luisi, C Fassorra, C Levanti, F Franchi
Journal of Chromatography A 1971
Anabolic effect of dihydrotestosterone in testicular feminization syndrome
CR Hamilton, B Kliman
Metabolism 1971
In vitro metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulphate in breast skin of women
MB Hodgins
Steroids 1971
Biochemical studies on the incomplete form of testicular feminization syndrome
G Pérez-Palacios, T Morato, AE Pérez, E Castañeda, C Gual
Steroids 1971
The XY female
CJ Dewhurst
American Journal of Obstetrics and Gynecology 1971
Metabolic studies in a patient with testicular feminization syndrome
E Castañeda, AE Perez, MA Guillen, S Ramirez-Robles, C Gual, G Pérez-Palacios
American Journal of Obstetrics and Gynecology 1971
Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes
J Kracht
1971
Partial Characterization of the Nuclear Reduced Nicotinamide Adenine Dinucleotide Phosphate: Δ4-3-Ketosteroid 5α-Oxidoreductase of Rat Prostate
DW Frederiksen, JD Wilson
The Journal of biological chemistry 1971
Androgen Metabolism in Human Skin
IF Sommerville, WP Collins, C Flamigni, EN Koullapis, CJ Dewhurst
Proceedings of the Royal Society of Medicine 1971
Vierundzwanzigste Österreichische Ärztetagung Wien Van-Swieten-Kongreß: 19. Oktober bis 24. Oktober 1970
G Harrer
1971
Studies on testosterone metabolism in subjects with testicular feminization syndrome
P Mauvais-Jarvis, JP Bercovici, O Crepy, F Gauthier
Journal of Clinical Investigation 1970
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson
Journal of Clinical Investigation 1970
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson
Journal of Clinical Investigation 1970
Testosterone
DW Killinger
Canadian Medical Association journal 1970
Skin collagen and thickness in women with hirsuties
S Shuster, MM Black, E Bottoms
British medical journal 1970
Proceedings of the 1969 Laurentian Hormone Conference
K Sterling
Proceedings of the 1969 Laurentian Hormone Conference 1970
5α-steroid reductase activity in tissues from rats with end organ insensitivity to testosterone
L Bullock, G Schneider, CW Bardin
Life Sciences 1970
Metabolism of radioactive 5α-androstane-3β, 17β-diol
P Mauvais-Jarvis, S Guillemant, P Corvol, HH Floch, L Bardou
Steroids 1970
Syndromes of Testicular Feminization: An Informal Appraisal and Review of the Latest Advances in Insights, with Special Emphasis on Pathogenesis, Biochemical Mechanisms at Work and Psychosocial Clinical Problems
RD Adams, B Kliman, DD Federman, HS Ulfelder, LB Holmes
Clinical Pediatrics 1970
The Human Testis
E Rosemberg, CA Paulsen
1970
Mammalian Reproduction
H Gibian, EJ Plotz
1970
Transformation of Testosterone into 17β-Hydroxy-5α-androstan-3-one by Microsomal Preparations of Human Skin
W Voigt, EP Fernandez, SL Hsia
The Journal of biological chemistry 1970
Intranuclear Metabolism of Progesterone-1,2-3H in the Hen Oviduct
MD Morgan, JD Wilson
The Journal of biological chemistry 1970
Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis
RB Jaffe
Steroids 1969
Receptor Proteins for Androgens
S Fang, KM Anderson, S Liao
The Journal of biological chemistry 1969
Advances in Lipid Research
AM Scanu
Advances in Lipid Research 1965
The role of pre-operative androgen stimulation in hypospadias surgery
Cevdet Kaya, Christian Radmayr
Translational andrology and urology

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