The influence of ouabain and alpha angelica lactone on 45calcium accumulation in cardiac microsomes was studied. Calcium binding (accumulation in the absence of excess oxalate or phosphate) was augmented by both ouabain and alpha angelica lactone in the presence of adenosine triphosphate (ATP) but unaffected in its absence. Calcium turnover (defined as the change in 45Ca++ bound to the microsomes after the specific activity is changed) was studied to determine if the augmented bound pool was freely exchangeable at equilibrium. Ouabain and alpha angelica lactone augmented calcium turnover in both the presence and absence of ATP. Calcium-stimulated ATPase was increased by both agents.
Mark L. Entman, Joseph W. Cook Jr., Rubin Bressler
Title and authors | Publication | Year |
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Current Topics in Membranes and Transport
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Current Topics in Membranes and Transport | 1983 |
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Pharmacology & Therapeutics | 1982 |
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Molecular and Cellular Endocrinology | 1976 |
Electromechanical studies on the inotropic effects of acetylstrophanthidin in ventricular muscle
AM Greenspan, M Morad |
The Journal of Physiology | 1975 |
Effect of anti-inflammatory drugs on the binding of calcium to cellular membranes in various human and guinea-pig tissues
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British Journal of Pharmacology | 1973 |
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AM Katz, DI Repke |
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Action of ultrasonicated epinephrine: Potentiation of isometric contraction in isolated papillary muscle from dog quiescent heart
AA Hakim |
Journal of Pharmaceutical Sciences | 1973 |
Uncoupling of fragmented sarcoplasmic reticulum's calcium uptake and extra ATPase activity found in the absence of oxalate
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Life Sciences | 1973 |
Catecholamines
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British heart journal | 1972 |
I. Quantitative Studies on the Time Course of Changes in Contractile Force Provoked by Changes in Heart Rate: II. Influence of Noradrenaline and Hexobarbital-NA
J Shaefer, PA van Zwieten |
Archives Of Physiology And Biochemistry | 1971 |
Biochemical and physiologic response to isoproterenol in patients with left ventricular failure
N Krasnow |
The American Journal of Cardiology | 1971 |
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G Dietze, KD Hepp |
Biochemical and Biophysical Research Communications | 1971 |
Characterization of dog cardiac microsomes Use of zonal centrifugation to fractionate fragmented sarcoplasmic reticulum, (Na+ + K+)-activated ATPase and mitochondrial fragments
AM Katz, DI Repke, JE Upshaw, MA Polascik |
Biochimica et Biophysica Acta (BBA) - Bioenergetics | 1970 |
Excitation-Contraction Coupling in Heart: I. – Comparison of calcium uptake by the sarcoplasmic reticulum and mitochondria of the rat heart
NS Dhalla |
Archives Of Physiology And Biochemistry | 1969 |
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ML Entman, GS Levey, SE Epstein |
Biochemical and Biophysical Research Communications | 1969 |
Effects of dimethyl sulphoxide, dimethyl formamide and dimethyl acetamide on myocardial contractility and enzyme activity
RA Burges, KJ Blackburn, BA Spilker |
Life Sciences | 1969 |
Calcium metabolism in cardiac microsomes incubated with lanthanum ion
ML Entman, JL Hansen, JW Cook |
Biochemical and Biophysical Research Communications | 1969 |
Effect of Cardiotonic Lactones on Calcium Metabolism of Dog Cardiac Microsomes
ML Entman, JO COOK, R Bressler |
Circulation research | 1969 |
Cardiac Glycosides
DG Friend |
New England Journal of Medicine | 1962 |