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Usage Information

Studies of red cell stromal proteins in Tay-Sachs disease
John A. Balint, Emilios C. Kyriakides
John A. Balint, Emilios C. Kyriakides
Published August 1, 1968
Citation Information: J Clin Invest. 1968;47(8):1858-1864. https://doi.org/10.1172/JCI105876.
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Research Article

Studies of red cell stromal proteins in Tay-Sachs disease

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Abstract

Hemoglobin-free red blood cell ghosts of nine patients with Tay-Sachs disease and 14 normal control subjects have been analyzed for content of total protein, hexosamines, individual amino acids, and sialic acid. Red cell ghosts from Tay-Sachs' children have been shown to contain significantly increased amounts of protein, hexosamine, threonine, and serine, and probably sialic acid, each of which was increased by approximately 25% over control values. These observations suggest that the red cell membrane in patients with Tay-Sachs disease contains a significant excess of a glycoprotein or proteins, as compared with normal, and that the metabolic defect in this disease, therefore, affects glycoproteins as well as complex lipids.

Authors

John A. Balint, Emilios C. Kyriakides

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