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Research Article Free access | 10.1172/JCI105862
1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Find articles by Schlaff, S. in: JCI | PubMed | Google Scholar
1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Find articles by Rosen, S. in: JCI | PubMed | Google Scholar
1Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Find articles by Roth, J. in: JCI | PubMed | Google Scholar
Published July 1, 1968 - More info
Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-131I were produced in rabbits and guinea pigs by repeated injections of FSH. By 131I immunochemical methods, we found that at least 90% of the FSH-131I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.