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Research Article Free access | 10.1172/JCI105857
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455
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Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Find articles by Crane, C. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Find articles by Frantz, I. in: JCI | PubMed | Google Scholar
Published July 1, 1968 - More info
The effect of cholestyramine on the fecal excretion of bile acids and neutral sterols was measured in a hypercholesterolemic patient on a low fat, high polyunsaturated fatty acid-containing diet after the intravenous injection of cholesterol-4-14C. A significant (16%) lowering of serum cholesterol concentration was accompanied by a 3.2-fold increase in fecal bile acid excretion but no change in neutral sterol output. The increased bile acid loss was adequate to account for the observed fall in serum cholesterol level. The implications of these findings were discussed.