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Research Article Free access | 10.1172/JCI105824

Study of purine metabolism in a xanthinuric female

Michael J. Bradford, Irwin H. Krakoff, Robert Leeper, and M. Earl Balis

1Sloan-Kettering Institute, Sloan-Kettering Division of Cornell University Graduate School of Medical Sciences, and the Department of Medicine of Memorial and James Ewing Hospitals, New York 10021

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1Sloan-Kettering Institute, Sloan-Kettering Division of Cornell University Graduate School of Medical Sciences, and the Department of Medicine of Memorial and James Ewing Hospitals, New York 10021

Find articles by Krakoff, I. in: JCI | PubMed | Google Scholar

1Sloan-Kettering Institute, Sloan-Kettering Division of Cornell University Graduate School of Medical Sciences, and the Department of Medicine of Memorial and James Ewing Hospitals, New York 10021

Find articles by Leeper, R. in: JCI | PubMed | Google Scholar

1Sloan-Kettering Institute, Sloan-Kettering Division of Cornell University Graduate School of Medical Sciences, and the Department of Medicine of Memorial and James Ewing Hospitals, New York 10021

Find articles by Balis, M. in: JCI | PubMed | Google Scholar

Published June 1, 1968 - More info

Published in Volume 47, Issue 6 on June 1, 1968
J Clin Invest. 1968;47(6):1325–1332. https://doi.org/10.1172/JCI105824.
© 1968 The American Society for Clinical Investigation
Published June 1, 1968 - Version history
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Abstract

A case of xanthinuria is briefly described, and the results of in vivo studies with 14C-labeled oxypurines are discussed. The data demonstrate that the rate of the turnover of uric acid is normal, despite an extremely small uric acid pool. Xanthine and hypoxanthine pools were measured and their metabolism evaluated. The bulk of the daily pool of 276 mg of xanthine, but only 6% of the 960 mg of hypoxanthine, is excreted. Thus, xanthine appears to be a metabolic end product, whereas hypoxanthine is an active intermediate. Biochemical implications of this finding are discussed.

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