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Research Article Free access | 10.1172/JCI105798

Characteristics of the RNA synthesized in vitro by the normal human small lymphocyte and the changes induced by phytohemagglutinin stimulation

Umberto L. Torelli, Patrick H. Henry, and Sherman M. Weissman

1Medicine and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

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1Medicine and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

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1Medicine and Metabolism Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Weissman, S. in: JCI | PubMed | Google Scholar

Published May 1, 1968 - More info

Published in Volume 47, Issue 5 on May 1, 1968
J Clin Invest. 1968;47(5):1083–1095. https://doi.org/10.1172/JCI105798.
© 1968 The American Society for Clinical Investigation
Published May 1, 1968 - Version history
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Abstract

These studies demonstrate that the circulating human small lymphocyte synthesizes ribonucleic acid (RNA) of high molecular weight which is not primarily a ribosomal precursor and which is, in part, complementary to human deoxyribonucleic acid (DNA). The stimulation of these lymphocytes by PHA brings a cell population in which few ribosomes are synthesized to a functional condition in which a large amount of these particles are produced. This increase in the synthesis of ribosomal RNA is one of the earliest and most relevant effects of PHA on the RNA metabolism of small lymphocytes.

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