Demonstration of a hormonal inhibitor of proximal tubular reabsorption during expansion of extracellular volume with isotonic saline

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Abstract

Evidence for the elaboration of a hormonal inhibitor of renal tubular reabsorption in response to expansion of extracellular fluid volume was obtained by examining the effects of plasma from rats and dogs undergoing saline diuresis on the rate of proximal tubular reabsorption measured both directly by micropuncture techniques and indirectly by clearance techniques.

Authors

Floyd C. Rector Jr., Manuel Martinez-Maldonado, Neil A. Kurtzman, Jack C. Sellman, Fred Oerther, Donald W. Seldin