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Research Article Free access | 10.1172/JCI105751
Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado
Department of Obstetrics-Gynecology, University of Colorado Medical Center, Denver, Colorado
Department of Physiology, University of Colorado Medical Center, Denver, Colorado
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Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado
Department of Obstetrics-Gynecology, University of Colorado Medical Center, Denver, Colorado
Department of Physiology, University of Colorado Medical Center, Denver, Colorado
Find articles by Meschia, G. in: JCI | PubMed | Google Scholar
Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado
Department of Obstetrics-Gynecology, University of Colorado Medical Center, Denver, Colorado
Department of Physiology, University of Colorado Medical Center, Denver, Colorado
Find articles by Makowski, E. in: JCI | PubMed | Google Scholar
Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado
Department of Obstetrics-Gynecology, University of Colorado Medical Center, Denver, Colorado
Department of Physiology, University of Colorado Medical Center, Denver, Colorado
Find articles by Bowes, W. in: JCI | PubMed | Google Scholar
Published March 1, 1968 - More info
In eight sheep, uterine and umbilical blood flows and oxygen uptakes, the transplacental flow-limited clearance of an inert molecule, pH values, and oxygen pressures, saturations, and capacities in the main placental vessels have been measured during maternal air breathing and oxygen inhalation. The mean ±SEM percentage changes during oxygen inhalation were +4.6 ±8.4 for the umbilical flow, +2.8 ±8.7 for the uterine flow, and +4.6 ±6.2 for the clearance. None of these changes are statistically significant. Oxygen uptake rose slightly in two cases and remained unchanged in the others. In all cases the oxygen pressures, saturations, and contents rose significantly in the uterine and umbilical vessels with oxygen inhalation.