Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia

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Abstract

The highly reactive pulmonary vascular bed of the neonatal calf was utilized to determine whether the hypoxic pulmonary pressor response is modified by α-adrenergic blockade with phenoxybenzamine (Group A) or by tissue catecholamine depletion with reserpine (Group B). In addition, in Group A, the effects of hypoxia on the pulmonary circulation were compared and contrasted with those of l-norepinephrine (α-receptor stimulator) and isoproterenol (β-receptor stimulator).

Authors

Eric D. Silove, Robert F. Grover