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Research Article Free access | 10.1172/JCI105690

Tyrosine Metabolism in Patients with Liver Disease

Robert J. Levine and Harold O. Conn

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Veterans Administration Hospital, West Haven, Connecticut

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, and the Veterans Administration Hospital, West Haven, Connecticut

*

Received for publication 19 May 1967 and in revised form 26 July 1967.

A partial account of this work was published in abstract form in Clin. Res. 1965. 13: 372.

This work was supported by grants from the Veterans Administration, the National Institute of Health (CA-08341), the Erwin Strasburger Memorial Medical Foundation, and the Stratfield Fund.

Address requests for reprints to Dr. Robert J. Levine, Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Conn. 06510.

Find articles by Levine, R. in: JCI | PubMed | Google Scholar

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Veterans Administration Hospital, West Haven, Connecticut

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, and the Veterans Administration Hospital, West Haven, Connecticut

*

Received for publication 19 May 1967 and in revised form 26 July 1967.

A partial account of this work was published in abstract form in Clin. Res. 1965. 13: 372.

This work was supported by grants from the Veterans Administration, the National Institute of Health (CA-08341), the Erwin Strasburger Memorial Medical Foundation, and the Stratfield Fund.

Address requests for reprints to Dr. Robert J. Levine, Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Conn. 06510.

Find articles by Conn, H. in: JCI | PubMed | Google Scholar

Published December 1, 1967 - More info

Published in Volume 46, Issue 12 on December 1, 1967
J Clin Invest. 1967;46(12):2012–2020. https://doi.org/10.1172/JCI105690.
© 1967 The American Society for Clinical Investigation
Published December 1, 1967 - Version history
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Abstract

Plasma levels of tyrosine were assayed in the fasting state and after oral administration of either tyrosine (tyrosine tolerance test) or phenylalanine (phenlyalanine conversion test) in normal subjects and in patients with hepatitis, biliary obstruction, or cirrhosis. Fasting tyrosine levels tended to be slightly increased in patients with hepatitis and biliary obstruction and markedly increased in patients with cirrhosis.

Tyrosine tolerance tests in patients with cirrhosis were characterized by larger than normal increments in tyrosine levels and by delayed returns toward fasting levels.

The results of phenylalanine conversion tests were abnormal in approximately one-half of patients with either hepatitis or biliary obstruction and four-fifths of patients with cirrhosis. Abnormalities were characterized by elevated fasting plasma tyrosine levels, or small and delayed increments in tyrosine levels, or both. Abnormal phenylalanine conversion test results in patients with cirrhosis did not correlate closely with any clinical feature of cirrhosis or with the results of any standard liver function test; there was positive correlation only with abnormal ammonia tolerance, a test of portalsystemic shunting. Tests of tyrosine metabolism do not appear to be useful for routine clinical assessment of liver function. Tyrosine tolerance tests and phenylalanine conversion tests done for purposes of diagnosis of other diseases may yield misleading results in patients with liver disease.

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Referenced in 1 policy sources
Referenced in 2 patents
23 readers on Mendeley
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