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Usage Information

Aldosterone in Metabolic Alkalosis
Jerome P. Kassirer, … , Joseph A. Chazan, William B. Schwartz
Jerome P. Kassirer, … , Joseph A. Chazan, William B. Schwartz
Published October 1, 1967
Citation Information: J Clin Invest. 1967;46(10):1558-1571. https://doi.org/10.1172/JCI105647.
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Research Article Article has an altmetric score of 1

Aldosterone in Metabolic Alkalosis

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Abstract

Studies have been carried out in human volunteer subjects to evaluate the role of aldosterone in the development, maintenance, and correction of metabolic alkalosis induced by selective depletion of hydrochloric acid. During the first phase of our study the rate of aldosterone secretion was measured before the induction of alkalosis (while the subjects were on a low salt diet) and again after a steady state of metabolic alkalosis had been established. The data demonstrate a fall in aldosterone secretion from a value of approximately 500 μg/day to a value of approximately 200 μg/day. Thus, it appears that an increased rate of aldosterone secretion is not a prerequisite to the elevation of the renal bicarbonate threshold.

Authors

Jerome P. Kassirer, Frederick M. Appleton, Joseph A. Chazan, William B. Schwartz

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 179 42
PDF 57 12
Scanned page 528 18
Citation downloads 66 0
Totals 830 72
Total Views 902
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ISSN: 0021-9738 (print), 1558-8238 (online)

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