Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome

Brigid G. Leventhal; Donald S. Waldorf; Norman Talal

doi:10.1172/JCI105626

National Cancer Institute and National Institute of Arthritis and Metabolic Diseases, Bethesda, Md.

†

Address requests for reprints to Dr. Brigid G. Leventhal, Leukemia Service, Medicine Branch, National Cancer Institute, Bethesda, Md. 20014.

‡

Current address: Dept. of Dermatology, New York University School of Medicine, New York, N. Y.

Submitted for publication February 7, 1967; accepted April 20, 1967.

Presented at the Annual Meeting of the American Rheumatism Association in Denver, Colo., on June 18, 1966.

Find articles by Leventhal, B. in: JCI | PubMed | Google Scholar

National Cancer Institute and National Institute of Arthritis and Metabolic Diseases, Bethesda, Md.

†

Address requests for reprints to Dr. Brigid G. Leventhal, Leukemia Service, Medicine Branch, National Cancer Institute, Bethesda, Md. 20014.

‡

Current address: Dept. of Dermatology, New York University School of Medicine, New York, N. Y.

Submitted for publication February 7, 1967; accepted April 20, 1967.

Presented at the Annual Meeting of the American Rheumatism Association in Denver, Colo., on June 18, 1966.

Find articles by Waldorf, D. in: JCI | PubMed | Google Scholar

National Cancer Institute and National Institute of Arthritis and Metabolic Diseases, Bethesda, Md.

†

Address requests for reprints to Dr. Brigid G. Leventhal, Leukemia Service, Medicine Branch, National Cancer Institute, Bethesda, Md. 20014.

‡

Current address: Dept. of Dermatology, New York University School of Medicine, New York, N. Y.

Submitted for publication February 7, 1967; accepted April 20, 1967.

Presented at the Annual Meeting of the American Rheumatism Association in Denver, Colo., on June 18, 1966.

Find articles by Talal, N. in: JCI | PubMed | Google Scholar

Published in Volume 46, Issue 8 on August 1, 1967
J Clin Invest. 1967;46(8):1338–1345. https://doi.org/10.1172/JCI105626.
© 1967 The American Society for Clinical Investigation

Published August 1, 1967 - Version history

In vitro lymphocyte transformation in response to phytohemagglutinin and streptolysin O and in vivo skin sensitization to 2,4-dinitrochloro-benzene has been studied in patients with Sjögren's syndrome and in normal controls of comparable age and sex. Both the in vivo and in vitro responses were significantly impaired in the Sjögren's patients as compared to the controls. This lack of response to mitogenic agents is probably due to an intrinsic defect in the lymphocytes rather than to a serum factor. The abnormalities were less marked in patients whose disease was localized to the parotid and lacrimal glands than in those with generalized disease, i.e., with complicating rheumatoid arthritis or pseudolymphoma.