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Usage Information

Acid-Base Alterations and Renal Gluconeogenesis: Effect of pH, Bicarbonate Concentration, and PCO2
Donald E. Kamm, … , A. David Goodman, George F. Cahill Jr.
Donald E. Kamm, … , A. David Goodman, George F. Cahill Jr.
Published July 1, 1967
Citation Information: J Clin Invest. 1967;46(7):1172-1177. https://doi.org/10.1172/JCI105610.
View: Text | PDF
Research Article

Acid-Base Alterations and Renal Gluconeogenesis: Effect of pH, Bicarbonate Concentration, and PCO2

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Abstract

In previous studies it was found that renal cortical slices from rats with induced metabolic acidosis have an increased capacity to produce glucose, whereas cortical slices from rats with metabolic alkalosis manifest decreased gluconeogenesis. To evaluate the relative influence of extracellular fluid pH, [HCO3-], and carbon dioxide tension on renal gluconeogenesis, we observed glucose production by cortex from rats with induced respiratory acidosis, and by cortex taken from normal animals and incubated in acid and alkaline media.

Authors

Donald E. Kamm, Robert E. Fuisz, A. David Goodman, George F. Cahill Jr.

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 153 9
PDF 70 11
Scanned page 234 6
Citation downloads 61 0
Totals 518 26
Total Views 544
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