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Research Article Free access | 10.1172/JCI105603
University of Melbourne Department of Medicine, Victoria, Australia
†Address requests for reprints to Dr. P. J. Nestel, Dept. of Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
*Submitted for publication November 16, 1966; accepted March 3, 1967.
Supported by a grant from the National Heart Foundation of Australia.
Find articles by Nestel, P. in: JCI | PubMed | Google Scholar
University of Melbourne Department of Medicine, Victoria, Australia
†Address requests for reprints to Dr. P. J. Nestel, Dept. of Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
*Submitted for publication November 16, 1966; accepted March 3, 1967.
Supported by a grant from the National Heart Foundation of Australia.
Find articles by Monger, E. in: JCI | PubMed | Google Scholar
Published June 1, 1967 - More info
The turnover rate of plasma total esterified cholesterol was measured after the intravenous injection of tritiated mevalonic acid in 16 men with coronary heart disease. Four subjects were normocholesterolemic and 12 were hypercholesterolemic; among the latter, 3 suffered from familial hypercholesterolemia and 6 were overweight.
The turnover rate of plasma esterified cholesterol was highest among the overweight hypercholesterolemic subjects and least among the subjects with familial hypercholesterolemia. Hypercholesterolemic subjects of normal weight had turnover rates similar to those found in normocholesterolemic men.
Significant correlations were found between body surface or body weight and the turnover rate of plasma esterified cholesterol.
We conclude that the factors which determine the development of hypercholesterolemia are not identical in all hypercholesterolemic subjects and that when hypercholesterolemia is associated with overweight there is an increased formation of at least plasma esterified cholesterol.