Immunoreactive insulin, like inulin, quickly equilibrates with interstitial fluid, as evidenced by recovery in thoracic duct lymph in man. Insulin-like activity not accounted for by immunoreactive insulin behaves as a large protein and is confined to the vascular compartment.
Eugenio A. Rasio, Constantine L. Hampers, J. Stuart Soeldner, George F. Cahill Jr.
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