Citations to this article

Serum-Red Cell Interactions at Low Ionic Strength: Erythrocyte Complement Coating and Hemolysis of Paroxysmal Nocturnal Hemoglobinuria Cells
David E. Jenkins Jr., … , Robert C. Hartmann, Albert L. Kerns
David E. Jenkins Jr., … , Robert C. Hartmann, Albert L. Kerns
Published May 1, 1967
Citation Information: J Clin Invest. 1967;46(5):753-761. https://doi.org/10.1172/JCI105576.
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Research Article

Serum-Red Cell Interactions at Low Ionic Strength: Erythrocyte Complement Coating and Hemolysis of Paroxysmal Nocturnal Hemoglobinuria Cells

Abstract

Complement coating and hemolysis were observed when erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) were incubated in isotonic sucrose solution in the presence of small amounts of serum. Normal cells were likewise coated with complement components but did not hemolyze. Both normal and PNH erythrocytes reduced the hemolytic complement activity of the serum used in this reaction.

Authors

David E. Jenkins Jr., Robert C. Hartmann, Albert L. Kerns

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Year: 2012 2009 2000 1988 1985 1983 1981 1979 1978 1975 1973 1972 1969 1968 Total
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Citation information

Citations to this article (19)

Title and authors Publication Year
The Laboratory Diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH): Update 2010
JS Krauss 		Laboratory Medicine 2012
THE SUCROSE HAEMOLYSIS TEST IN PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA
NE Hansen 		Acta Medica Scandinavica 2009
Inhibition of complement-mediated haemolysis in paroxysmal nocturnal haemoglobinuria by heparin or low-molecular weight heparin
H Ninomiya, Y Kawashima, T Nagasawa 		British Journal of Haematology 2000
PNH and the GPI-Linked Proteins
CJ Parker 		PNH and the GPI-Linked Proteins 2000
Increased sensitivity to complement of megakaryocyte progenitors in paroxysmal nocturnal haemoglobinuria
EN Dessypris, JH Gleaton, DA Clark 		British Journal of Haematology 1988
Paroxysmal Nocturnal Haemoglobinuria
WF Rosse, CJ Parker 		Clinics in Haematology 1985
Increased Sensitivity to Complement of Erythroid and Myeloid Progenitors in Paroxysmal Nocturnal Hemoglobinuria
EN Dessypris, DA Clark, LC McKee, SB Krantz 		New England Journal of Medicine 1983
Complement and Ig Uptake by Erythrocytes in Low Ionic Strength Solutions
IO Szymanski, MG Keegan, PR Odgren 		Vox Sanguinis 1981
The Low Ionic Strength Reaction of Human Blood: Relationship between the Binding of Serum Immunoglobulin and Complement to Red Blood Cells and Surface Charge of the Cells
TC Hsu, J Steinberg, R Doux, A Sawitsky 		British Journal of Haematology 1979
Relations between Surface Charge and in Vitro Lysis of Red Blood Cells in Paroxysmal Nocturnal Haemoglobinuria
LL Hause, SM Koethe, DJ Rothwell, JV Straumfjord 		Scandinavian Journal of Haematology 1978
A Rapid Method for the Production of Erythrocytes in the State “EC4” and “EC43”
DE Jenkins, WH Moore, DG Luthringer, RM Johnson 		Transfusion 1975
Study of Two in Vitro Diagnostic Tests for Paroxysmal Nocturnal Haemoglobinuria
G Sirchia, E Marubini, F Mercuriali, S Ferrone 		British Journal of Haematology 1973
Contemporary Topics in Molecular Immunology
RA Reisfeld, WJ Mandy 		1973
Study of in Vitro Lysis of Paroxysmal Nocturnal Haemoglobinuria (PNH) and PNH-like Red Cells
S Ferrone, E Marubini, F Mercuriali, G Sirchia 		British Journal of Haematology 1972
Lysis of red cells from haematological disorders
N Stathakis, G Arapakis, K Kirkou, C Gardikas 		Journal of clinical pathology 1972
A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies
RH Aster, SE Enright 		Journal of Clinical Investigation 1969
The in Vitro Lysis of the Red Cells of Paroxysmal Nocturnal Haemoglobinuria by the Serum of Patients with Cirrhosis of the Liver
G Sirchia, S Ferrone, F Mercuriali 		British Journal of Haematology 1969
In-Vitro Lysis of AET-Treated Normal Red Cells (PNH-like Cells) by Normal and Cirrhotic Sera
G Sirchia, S Ferrone, F Mercuriali 		British Journal of Haematology 1969
THE SUCROSE HAEMOLYSIS TEST IN PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA: Studies on Erythrocytes and Bone Marrow Cells
NE Hansen 		Acta Medica Scandinavica 1968

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