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Studies on Zinc Deficiency: Changes in Trace Elements and Enzyme Activities in Tissues of Zinc-deficient Rats
Ananda S. Prasad, … , Ray Collins, Janice M. Vazquez
Ananda S. Prasad, … , Ray Collins, Janice M. Vazquez
Published April 1, 1967
Citation Information: J Clin Invest. 1967;46(4):549-557. https://doi.org/10.1172/JCI105556.
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Research Article

Studies on Zinc Deficiency: Changes in Trace Elements and Enzyme Activities in Tissues of Zinc-deficient Rats

Abstract

Zinc content of testes, bones, esophagus, kidneys, and muscles was decreased, whereas iron content was increased in the testes of zinc-deficient rats compared to restrictedly fed control rats. Histochemical enzyme determinations revealed reduced activities of certain enzymes in the testes, bones, esophagus, and kidneys. In the testes, lactic dehydrogenase (LDH), malic dehydrogenase (MDH), alcohol dehydrogenase (ADH), and NADH diaphorase; in the bones, LDH, MDH, ADH, and alkaline phosphatase; in the esophagus, MDH, ADH, and NADH diaphorase; and in the kidneys, MDH and alkaline phosphatase were decreased in zinc-deficient rats compared to restrictedly fed controls. Succinic dehydrogenase (SDH) revealed no significant changes under the conditions of our experiments in various groups of rats that were investigated.

Authors

Ananda S. Prasad, Donald Oberleas, Paul Wolf, Jerome P. Horwitz, Ray Collins, Janice M. Vazquez

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