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Research Article Free access | 10.1172/JCI105522

ACTH Antibodies in Patients Receiving Depot Porcine ACTH to Hasten Recovery from Pituitary-Adrenal Suppression

Norman Fleischer, Kaoru Abe, Grant W. Liddle, David N. Orth, and Wendell E. Nicholson

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

†

Address requests for reprints to Dr. Grant W. Liddle, Vanderbilt University School of Medicine, Nashville, Tenn. 37203.

*

Submitted for publication July 11, 1966; accepted October 20, 1966.

These studies were supported in part by the following grants-in-aid from the National Institutes of Health of the U. S. Public Health Service: 5-K6-AM-3782, 8-MOI-FR-95, T1-AM-5092, and 5-ROI-AM-05318.

Find articles by Fleischer, N. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

†

Address requests for reprints to Dr. Grant W. Liddle, Vanderbilt University School of Medicine, Nashville, Tenn. 37203.

*

Submitted for publication July 11, 1966; accepted October 20, 1966.

These studies were supported in part by the following grants-in-aid from the National Institutes of Health of the U. S. Public Health Service: 5-K6-AM-3782, 8-MOI-FR-95, T1-AM-5092, and 5-ROI-AM-05318.

Find articles by Abe, K. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

†

Address requests for reprints to Dr. Grant W. Liddle, Vanderbilt University School of Medicine, Nashville, Tenn. 37203.

*

Submitted for publication July 11, 1966; accepted October 20, 1966.

These studies were supported in part by the following grants-in-aid from the National Institutes of Health of the U. S. Public Health Service: 5-K6-AM-3782, 8-MOI-FR-95, T1-AM-5092, and 5-ROI-AM-05318.

Find articles by Liddle, G. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

†

Address requests for reprints to Dr. Grant W. Liddle, Vanderbilt University School of Medicine, Nashville, Tenn. 37203.

*

Submitted for publication July 11, 1966; accepted October 20, 1966.

These studies were supported in part by the following grants-in-aid from the National Institutes of Health of the U. S. Public Health Service: 5-K6-AM-3782, 8-MOI-FR-95, T1-AM-5092, and 5-ROI-AM-05318.

Find articles by Orth, D. in: JCI | PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

†

Address requests for reprints to Dr. Grant W. Liddle, Vanderbilt University School of Medicine, Nashville, Tenn. 37203.

*

Submitted for publication July 11, 1966; accepted October 20, 1966.

These studies were supported in part by the following grants-in-aid from the National Institutes of Health of the U. S. Public Health Service: 5-K6-AM-3782, 8-MOI-FR-95, T1-AM-5092, and 5-ROI-AM-05318.

Find articles by Nicholson, W. in: JCI | PubMed | Google Scholar

Published February 1, 1967 - More info

Published in Volume 46, Issue 2 on February 1, 1967
J Clin Invest. 1967;46(2):196–204. https://doi.org/10.1172/JCI105522.
© 1967 The American Society for Clinical Investigation
Published February 1, 1967 - Version history
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Abstract

Six patients who had experienced prolonged steroid-induced pituitary-adrenal suppression were treated with 100 U of depot procine ACTH every 2 to 4 days for several months. Such treatment did not hasten the recovery of normal pituitary-adrenal function compared with the rate of recovery of a group of similarly suppressed patients who received no depot ACTH. Eight of nine patients who received prolonged courses of depot porcine ACTH developed antibodies to ACTH that cross-reacted with endogenous ACTH, binding it in the circulation in inactive form and retarding its removal from the circulation. The presence of such antibodies did not in itself grossly alter pituitary-adrenal interrelationships.

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