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Research Article Free access | 10.1172/JCI105517
Cardeza Foundation for Hematologic Research, Jefferson Medical College. Philadelphia, Pa.
†Address requests for reprints to Dr. Sandor S. Shapiro, Cardeza Foundation for Hematologic Research, Jefferson Medical College, 1015 Sansom St., Philadelphia, Pa. 19107.
*Submitted for publication July 5, 1966; accepted October 13, 1966.
Supported by research grant HE-09163 from the National Institutes of Health.
A portion of this work was published in abstract form in J. clin. Invest. 1966, 45, 1072.
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Published February 1, 1967 - More info
Investigations were undertaken of the chemical nature and kinetics of interaction of three acquired inhibitors of Factor VIII. The inhibition was stoichiometric, one molecule of inhibitor (or one site on a molecule) being required to inactivate one molecule of Factor VIII. All three inhibitors were found to be monotypic antibodies of class IgG, Type K (γ2 κ2). This appears to be the second syndrome due to the production of monotypic antibody, and the first instance involving IgG immunoglobulins.
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