INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT. VII. ENZYMATIC DEGRADATION OF ENDOTOXIN BY BLOOD PLASMA

Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.

Present address: U. S. Public Health Service Hospital, Boston, Mass.

In previous reports it was convenient to use a brief, tentative designation (EDC) for the component in blood responsible for the detoxification of endotoxin in vitro. More recent studies in this Laboratory indicate that there may be more than one host enzyme capable of catalyzing this reaction; e.g., endotoxin can be inactivated in vitro by tissue homogenates under conditions which differ from those required for detoxification by blood (1, 2). In the present report, the host product employed as a source of endotoxin-inactivating enzyme is referred to, simply, as plasma or serum.

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Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.

Present address: U. S. Public Health Service Hospital, Boston, Mass.

In previous reports it was convenient to use a brief, tentative designation (EDC) for the component in blood responsible for the detoxification of endotoxin in vitro. More recent studies in this Laboratory indicate that there may be more than one host enzyme capable of catalyzing this reaction; e.g., endotoxin can be inactivated in vitro by tissue homogenates under conditions which differ from those required for detoxification by blood (1, 2). In the present report, the host product employed as a source of endotoxin-inactivating enzyme is referred to, simply, as plasma or serum.

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Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.

Present address: U. S. Public Health Service Hospital, Boston, Mass.

In previous reports it was convenient to use a brief, tentative designation (EDC) for the component in blood responsible for the detoxification of endotoxin in vitro. More recent studies in this Laboratory indicate that there may be more than one host enzyme capable of catalyzing this reaction; e.g., endotoxin can be inactivated in vitro by tissue homogenates under conditions which differ from those required for detoxification by blood (1, 2). In the present report, the host product employed as a source of endotoxin-inactivating enzyme is referred to, simply, as plasma or serum.

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