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Research Article Free access | 10.1172/JCI103016

Clinical Effects of the Dichloro and Monochlorophenyl Analogues of Diamino Pyrimidine: Antagonists of Folic Acid

M. Lois Murphy, Rose Ruth Ellison, David A. Karnofsky, and Joseph H. Burchenal

aChemotherapy Service, Memorial Center, and the Division of Experimental Chemotherapy, Sloan-Kettering Institute, New York, N. Y.

1

This investigation was supported by research grants from the American Cancer Society, the Damon Runyon Memorial Fund for Cancer Research, the Lasker Foundation and the Grant Foundation, and by Grant C-1889 from the National Cancer Institute of the National Institutes of Health of the United States Public Health Service.

2

We wish to express our appreciation to Dr. George H. Hitchings of the Wellcome Research Laboratories for the supply of DDMP and the Lederle Laboratories Division of the American Cyanamid Company for the supply of Leucovorin.

Find articles by Murphy, M. in: PubMed | Google Scholar

aChemotherapy Service, Memorial Center, and the Division of Experimental Chemotherapy, Sloan-Kettering Institute, New York, N. Y.

1

This investigation was supported by research grants from the American Cancer Society, the Damon Runyon Memorial Fund for Cancer Research, the Lasker Foundation and the Grant Foundation, and by Grant C-1889 from the National Cancer Institute of the National Institutes of Health of the United States Public Health Service.

2

We wish to express our appreciation to Dr. George H. Hitchings of the Wellcome Research Laboratories for the supply of DDMP and the Lederle Laboratories Division of the American Cyanamid Company for the supply of Leucovorin.

Find articles by Ellison, R. in: PubMed | Google Scholar

aChemotherapy Service, Memorial Center, and the Division of Experimental Chemotherapy, Sloan-Kettering Institute, New York, N. Y.

1

This investigation was supported by research grants from the American Cancer Society, the Damon Runyon Memorial Fund for Cancer Research, the Lasker Foundation and the Grant Foundation, and by Grant C-1889 from the National Cancer Institute of the National Institutes of Health of the United States Public Health Service.

2

We wish to express our appreciation to Dr. George H. Hitchings of the Wellcome Research Laboratories for the supply of DDMP and the Lederle Laboratories Division of the American Cyanamid Company for the supply of Leucovorin.

Find articles by Karnofsky, D. in: PubMed | Google Scholar

aChemotherapy Service, Memorial Center, and the Division of Experimental Chemotherapy, Sloan-Kettering Institute, New York, N. Y.

1

This investigation was supported by research grants from the American Cancer Society, the Damon Runyon Memorial Fund for Cancer Research, the Lasker Foundation and the Grant Foundation, and by Grant C-1889 from the National Cancer Institute of the National Institutes of Health of the United States Public Health Service.

2

We wish to express our appreciation to Dr. George H. Hitchings of the Wellcome Research Laboratories for the supply of DDMP and the Lederle Laboratories Division of the American Cyanamid Company for the supply of Leucovorin.

Find articles by Burchenal, J. in: PubMed | Google Scholar

Published October 1, 1954 - More info

Published in Volume 33, Issue 10 on October 1, 1954
J Clin Invest. 1954;33(10):1388–1396. https://doi.org/10.1172/JCI103016.
© 1954 The American Society for Clinical Investigation
Published October 1, 1954 - Version history
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