Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article (37)

Advertisement

Research Article Free access | 10.1172/JCI103001

The Mechanism of the Osmotic Adjustment of Body Cells as Determined IN VIVO BY THE VOLUME OF DISTRIBUTION OF A LARGE WATER LOAD

Alexander Leaf, Jacques Y. Chatillon, Oliver Wrong, and Elbert P. Tuttle Jr.

Department of Medicine, Massachusetts General Hospital, Boston, Mass.

Department of Medicine, Harvard Medical School, Boston, Mass.

2

Howard R. Hughes Fellow in Medicine.

3

Postdoctorate Fellow in Medicine, National Heart Institute, U. S. Public Health Service.

1

This study was supported in part by grants from the Milton Fund of Harvard University, the American Heart Association, and the Greater Boston Chapter of the Massachusetts Heart Association.

Find articles by Leaf, A. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston, Mass.

Department of Medicine, Harvard Medical School, Boston, Mass.

2

Howard R. Hughes Fellow in Medicine.

3

Postdoctorate Fellow in Medicine, National Heart Institute, U. S. Public Health Service.

1

This study was supported in part by grants from the Milton Fund of Harvard University, the American Heart Association, and the Greater Boston Chapter of the Massachusetts Heart Association.

Find articles by Chatillon, J. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston, Mass.

Department of Medicine, Harvard Medical School, Boston, Mass.

2

Howard R. Hughes Fellow in Medicine.

3

Postdoctorate Fellow in Medicine, National Heart Institute, U. S. Public Health Service.

1

This study was supported in part by grants from the Milton Fund of Harvard University, the American Heart Association, and the Greater Boston Chapter of the Massachusetts Heart Association.

Find articles by Wrong, O. in: PubMed | Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston, Mass.

Department of Medicine, Harvard Medical School, Boston, Mass.

2

Howard R. Hughes Fellow in Medicine.

3

Postdoctorate Fellow in Medicine, National Heart Institute, U. S. Public Health Service.

1

This study was supported in part by grants from the Milton Fund of Harvard University, the American Heart Association, and the Greater Boston Chapter of the Massachusetts Heart Association.

Find articles by Tuttle, E. in: PubMed | Google Scholar

Published September 1, 1954 - More info

Published in Volume 33, Issue 9 on September 1, 1954
J Clin Invest. 1954;33(9):1261–1268. https://doi.org/10.1172/JCI103001.
© 1954 The American Society for Clinical Investigation
Published September 1, 1954 - Version history
View PDF
Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1261
page 1261
icon of scanned page 1262
page 1262
icon of scanned page 1263
page 1263
icon of scanned page 1264
page 1264
icon of scanned page 1265
page 1265
icon of scanned page 1266
page 1266
icon of scanned page 1267
page 1267
icon of scanned page 1268
page 1268
Version history
  • Version 1 (September 1, 1954): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article (37)

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts