Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
John J. Lehman, … , Denis M. Medeiros, Daniel P. Kelly
John J. Lehman, … , Denis M. Medeiros, Daniel P. Kelly
Published October 1, 2000
Citation Information: J Clin Invest. 2000;106(7):847-856. https://doi.org/10.1172/JCI10268.
View: Text | PDF
Article Article has an altmetric score of 3

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

  • Text
  • PDF
Abstract

Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. Recent studies have identified the transcriptional coactivator peroxisome proliferator–activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. We sought to determine whether PGC-1 controlled mitochondrial biogenesis and energy-producing capacity in the heart, a tissue specialized for high-capacity ATP production. We found that PGC-1 gene expression is induced in the mouse heart after birth and in response to short-term fasting, conditions known to increase cardiac mitochondrial energy production. Forced expression of PGC-1 in cardiac myocytes in culture induced the expression of nuclear and mitochondrial genes involved in multiple mitochondrial energy-transduction/energy-production pathways, increased cellular mitochondrial number, and stimulated coupled respiration. Cardiac-specific overexpression of PGC-1 in transgenic mice resulted in uncontrolled mitochondrial proliferation in cardiac myocytes leading to loss of sarcomeric structure and a dilated cardiomyopathy. These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands.

Authors

John J. Lehman, Philip M. Barger, Attila Kovacs, Jeffrey E. Saffitz, Denis M. Medeiros, Daniel P. Kelly

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
Citations: 8 25 33 37 45 37 29 29 26 24 31 28 29 34 27 33 32 26 12 12 9 12 8 2 3 591
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (591)

Title and authors Publication Year
The Role of microRNA-22 in Metabolism
Tomasini S, Vigo P, Margiotta F, Scheele US, Panella R, Kauppinen S
International Journal of Molecular Sciences 2025
Recent Insights on the Role of Nuclear Receptors in Alzheimer’s Disease: Mechanisms and Therapeutic Application
Shan X, Li D, Yin H, Tao W, Zhou L, Gao Y, Xing C, Zhang C
International Journal of Molecular Sciences 2025
Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination.
Mitra A, Mandal S, Banerjee K, Ganguly N, Sasmal P, Banerjee D, Gupta S
Current cardiology reports 2025
Chronic stress elicits sex-specific mitochondrial respiratory functional changes in the rat heart.
Odendaal-Gambrell CP, O'Brien C, Cairns M, Maarman GJ, Joseph DE, Smith C, Rautenbach F, Marnewick JL, Essop MF
Physiological reports 2025
Protective Effects of a Standardized Water Extract from the Stem of Ipomoea batatas L. Against High-Fat Diet-Induced Obesity
Lee CW, Yoon YS, Yoon YS, Chung KS, Kim MJ, Park G, Choi M, Jang YP, Lee KT
Nutrients 2025
Brain–body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms
Devine J, Monzel AS, Shire D, Rosenberg AM, Junker A, Cohen AA, Picard M
Life Metabolism 2025
Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury.
Xin C, Liu O, Sun M, Han P, Li X, Niu Q, Ma N, Yang X, Hei C, Liu P
Metabolic brain disease 2025
Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model.
Tanabe K, Zheng Q, Zhang X, Tanaka N, Hayashi C, Yokota A, Otsuka R, Katahira T, Kohjima M, Nakamuta M
Scientific reports 2025
WWP2 mediates the metabolic reprogramming of renal myofibroblasts to promote kidney fibrosis
Huimei Chen, Ran You, Jing Guo, Wei Zhou, Gabriel Chew, Nithya Devapragash, Jui Loh, Loreto Gesualdo, Yanwei Li, Yuteng Jiang, Elisabeth Tan, Shuang Chen, Paola Pontrelli, Francesco Pesce, Jacques Behmoaras, Aihua Zhang, Enrico Petretto
Journal of the American Society of Nephrology : JASN 2024
Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice
Dörmann N, Hammer E, Struckmann K, Rüdebusch J, Bartels K, Wenzel K, Schulz J, Gross S, Schwanz S, Martin E, Fielitz B, Pablo Tortola C, Hahn A, Benkner A, Völker U, Felix SB, Fielitz J
Frontiers in Cardiovascular Medicine 2024
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Qian L, Zhu Y, Deng C, Liang Z, Chen J, Chen Y, Wang X, Liu Y, Tian Y, Yang Y
Signal Transduction and Targeted Therapy 2024
Cardiac arrhythmogenesis: roles of ion channels and their functional modification
Lei M, Salvage SC, Jackson AP, Huang CL
Frontiers in physiology 2024
Estrogen-Related Receptor α: A Key Transcription Factor in the Regulation of Energy Metabolism at an Organismic Level and a Target of the ABA/LANCL Hormone Receptor System
Spinelli S, Bruschi M, Passalacqua M, Guida L, Magnone M, Sturla L, Zocchi E
International journal of molecular sciences 2024
Mitochondrial quality control in human health and disease.
Liu BH, Xu CZ, Liu Y, Lu ZL, Fu TL, Li GR, Deng Y, Luo GQ, Ding S, Li N, Geng Q
Military Medical Research 2024
Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
Lee S
Antioxidants 2024
TOWARD UNDERSTANDING THE CELLULAR CONTROL OF VERTEBRATE MINERALIZATION: THE POTENTIAL ROLE OF MITOCHONDRIA
Shapiro IM, Risbud MV, Landis WJ
Bone 2024
Research progress on miR-124-3p in the field of kidney disease.
Chen G, Wang Y, Zhang L, Yang K, Wang X, Chen X
BMC Nephrology 2024
Hormonal orchestra: mastering mitochondria's role in health and disease.
Al-Suhaimi E, AlQuwaie R, AlSaqabi R, Winarni D, Dewi FRP, AlRubaish AA, Shehzad A, Elaissari A
Endocrine 2024
Aging in Heart Failure: Embracing Biology Over Chronology: JACC Family Series.
Goyal P, Maurer MS, Roh J
JACC. Heart failure 2024
Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases.
Widjaja S, Antarianto RD, Hardiany NS
Current aging science 2024
Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms.
Devine J, Monzel AS, Shire D, Rosenberg AM, Junker A, Cohen AA, Picard M
bioRxiv : the preprint server for biology 2024
Sleep restriction exacerbates cardiac dysfunction in diabetic mice by causing cardiomyocyte death and fibrosis through mitochondrial damage
Zhang J, Zhao X, Tang J, Liu C, Zhang Y, Cai C, Du Q
Cell Death Discovery 2024
miR-30d Attenuates Pulmonary Arterial Hypertension via Targeting MTDH and PDE5A and Modulates the Beneficial Effect of Sildenafil.
Liang X, Zhou J, Wang H, Zhang Z, Yin M, Zhu Y, Li L, Chen C, Wei M, Hu M, Zhao C, Yao J, Li G, Dinh-Xuan AT, Xiao J, Bei Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024
Klf9 is essential for cardiac mitochondrial homeostasis.
Zhang L, Zhang M, Huang J, Huang J, Zhang Y, Zhang Y, Chen H, Wang C, Xi X, Fan H, Wang J, Jiang D, Tian J, Zhang J, Chang Y
Nature cardiovascular research 2024
Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review)
Sun S, Guo H, Chen G, Zhang H, Zhang Z, Wang X, Li D, Li X, Zhao G, Lin F
Molecular Medicine Reports 2024
Fine particulate matter‑induced cardiac developmental toxicity (Review)
Meng X, Du W, Sun Z
Experimental and Therapeutic Medicine 2024
MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway
Cui D, Liu H, Cao L, Du X, Liu D, Liu Z, Wang T, Yang H, Zheng X, Xie Z, Xu S, Bi J, Wang P
Journal of Translational Medicine 2024
Metabolic reprogramming via mitochondrial delivery for enhanced maturation of chemically induced cardiomyocyte‐like cells
Nam Y, Song Y, Seo SJ, Ko GR, Lee SH, Cha E, Kwak SM, Kim S, Shin M, Jin Y, Lee JS
MedComm 2024
Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond
Sun Q, Karwi QG, Wong N, Lopaschuk GD
Cardiovascular Research 2024
Sex differences in mitochondrial gene expression during viral myocarditis
Di Florio DN, Weigel GJ, Gorelov DJ, McCabe EJ, Beetler DJ, Shapiro KA, Bruno KA, Chekuri I, Jain A, Whelan ER, Salomon GR, Khatib S, Bonvie-Hill NE, Fliess JJ, Giresi PG, Hamilton C, Hartmoyer CJ, Balamurugan V, Darakjian AA, Edenfield BH, Kocsis SC, McLeod CJ, Cooper LT Jr, Audet-Walsh É, Coronado MJ, Sin J, Fairweather D
Biology of Sex Differences 2024
Transition from fetal to postnatal state in the heart: Crosstalk between metabolism and regeneration
Sada T, Kimura W
Development, Growth & Differentiation 2024
PGC-1α Promotes mitochondrial biosynthesis and energy metabolism of goose fatty liver
Li J, Lv M, Yuan Z, Ge J, Geng T, Gong D, Zhao M
Poultry Science 2024
Mitonuclear Communication in Stem Cell Function.
Peng B, Wang Y, Zhang H
Cell proliferation 2024
Receptor interacting protein 140 (Nrip1) controls cardiac fuel metabolism and function
Tsunehisa Yamamoto, Kirill Batmanov, Santosh Maurya, Elizabeth Pruzinsky, Yang Xiao, Yang Wang, Ling Lai, Kendra McDaid, Swapnil Shewale, Teresa Leone, Pieterjan Dierickx, Mitchell Lazar, E. Lewandowski, Daniel Kelly
Journal of Clinical Investigation 2023
Exercise metabolism: from individual players to a team sport
Jeremy M. Robbins, Robert E. Gerszten
Journal of Clinical Investigation 2023
Brain nuclear receptors and cardiovascular function
Wang M, Yang Y, Xu Y
Cell & Bioscience 2023
The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure
Werbner B, Tavakoli-Rouzbehani OM, Fatahian AN, Boudina S
2023
Hypermethylation of the Bmp4 promoter dampens binding of HIF-1α and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring
Gao LT, Yuan JQ, Zhang ZY, Zhao HM, Gao L
Cellular and Molecular Life Sciences 2023
The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
Zhou S, Hum J, Taskintuna K, Olaya S, Steinman J, Ma J, Golestaneh N
Antioxidants 2023
Failure to Launch: Impaired Cardiac Mitochondrial Metabolic Development in Newborns With Single Ventricle Heart Failure
Lopaschuk GD, Persad KL
JACC: Basic to Translational Science 2023
Cardiomyocyte electrophysiology and its modulation: current views and future prospects
Huang CL, Lei M
Philosophical Transactions of the Royal Society B: Biological Sciences 2023
Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts.
Song H, Thompson LP
Reproductive sciences (Thousand Oaks, Calif.) 2023
Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover.
Huang M, Claussnitzer M, Saadat A, Coral DE, Kalamajski S, Franks PW
Diabetologia 2023
Mitochondrial Dysfunction in the Cardio-Renal Axis
Barbero NM, Oller J, Sanz AB, Ramos AM, Ortiz A, Ruiz-Ortega M, Rayego-Mateos S
International journal of molecular sciences 2023
Cellular Mechanisms Mediating Exercise-Induced Protection against Cardiotoxic Anthracycline Cancer Therapy
Dozic S, Howden EJ, Bell JR, Mellor KM, Delbridge LM, Weeks KL
Cells 2023
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O\u2019Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S
Basic Research in Cardiology 2023
Integrated Control of Fatty Acid Metabolism in Heart Failure
Li X, Bi X
Metabolites 2023
Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db/db mice.
Han JY, Park M, Lee HJ
2023
Synergistic effects of hormones on structural and functional maturation of cardiomyocytes and implications for heart regeneration.
Galow AM, Brenmoehl J, Hoeflich A
Cellular and molecular life sciences : CMLS 2023
The mitophagy pathway and its implications in human diseases.
Wang S, Long H, Hou L, Feng B, Ma Z, Wu Y, Zeng Y, Cai J, Zhang DW, Zhao G
Signal Transduction and Targeted Therapy 2023
Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease
Tryphena KP, Anuradha U, Kumar R, Rajan S, Srivastava S, Singh SB, Khatri DK
Journal of Alzheimer's disease : JAD 2023
Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation.
Zhong Z, Li X, Gao L, Wu X, Ye Y, Zhang X, Zeng Q, Zhou C, Lu X, Wei Y, Ding Y, Chen S, Zhou G, Xu J, Liu S
Cardiovascular Drugs and Therapy 2023
The cardioprotective effect of S. africana caerulea/Blue Sage in ischaemia and reperfusion induced oxidative stress
Salie R, Lopes J, Kotze L, van Aarde R
Frontiers in pharmacology 2023
Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Rabkin SW, Wong CN
Biomedicines 2023
Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue
Du J, Sudlow LC, Shahverdi K, Zhou H, Michie M, Schindler TH, Mitchell JD, Mollah S, Berezin MY
2023
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Wang J, Zhao YT, Zhang LX, Dubielecka PM, Qin G, Chin YE, Gower AC, Zhuang S, Liu PY, Zhao TC
AJP Cell Physiology 2023
Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation
Tiwari A, Hashemiaghdam A, Laramie MA, Maschi D, Haddad T, Stunault MI, Bergom C, Javaheri A, Klyachko V, Ashrafi G
The Journal of Cell Biology 2023
Neuronal Gtf2i deletion alters mitochondrial and autophagic properties.
Nir Sade A, Levy G, Schokoroy Trangle S, Elad Sfadia G, Bar E, Ophir O, Fischer I, Rokach M, Atzmon A, Parnas H, Rosenberg T, Marco A, Elroy Stein O, Barak B
Communications biology 2023
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, Zhao R, Lam HC, Oldham WM, Ei-Chemaly S, Agrawal PB, Tian J, Liu X, Perrella MA
Basic Research in Cardiology 2023
Fucoxanthin Abrogates Ionizing Radiation-Induced Inflammatory Responses by Modulating Sirtuin 1 in Macrophages.
Kang H, Kim SC, Oh Y
Marine drugs 2023
Mitochondrial might: powering the peripartum for risk and resilience
Gorman-Sandler E, Wood G, Cloude N, Frambes N, Brennen H, Robertson B, Hollis F
Frontiers in behavioral neuroscience 2023
Sex differences in mitochondrial gene expression during viral myocarditis
Di Florio D, Gorelov D, McCabe E, Beetler D, Shapiro K, Bruno K, Chekuri I, Jain A, Whelan E, Salomon G, Khatib S, Bonvie-Hill N, Giresi P, Balamurugan V, Weigel G, Fliess J, Darakjian A, Edenfield B, Kocsis C, McLeod C, Cooper L, Audet-Walsh E, Coronado M, Sin J, Fairweather D
Research square 2023
Raising NAD+ level stimulates short-chain dehydrogenase/reductase proteins to alleviate heart failure independent of mitochondrial protein deacetylation
Walker MA, Chen H, Yadav A, Ritterhoff J, Villet O, McMillen T, Wang Y, Purcell H, Djukovic D, Raftery D, Isoherranen N, Tian R
Circulation 2023
Cardiac Maturation
Sakamoto T, Kelly DP
Journal of Molecular and Cellular Cardiology 2023
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise
Hastings MH, Castro C, Freeman R, Abdul Kadir A, Lerchenmüller C, Li H, Rhee J, Roh JD, Roh K, Singh AP, Wu C, Xia P, Zhou Q, Xiao J, Rosenzweig A
JACC: Basic to Translational Science 2023
Mitochondrial regulation of local supply of energy in neurons
López-Doménech G, Kittler JT
Current Opinion in Neurobiology 2023
Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z
D Rudnick, J Huang, T Hidvegi, A Chu, P Hale, A Munanairi, D Dietzen, P Cliften, E Tycksen, A Lutkewitte, B Finck, S Pak, G Silverman, D Perlmutter
Gastroenterology 2022
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
T Yamamoto, M Sano
International journal of molecular sciences 2022
Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure
JD Panes, A Wendt, O Ramirez-Molina, PA Castro, J Fuentealba
NEURAL REGEN RES 2022
Thyroid hormone-dependent regulation of metabolism and heart regeneration
I Ross, D Omengan, G Huang, A Payumo
Journal of Endocrinology 2022
Regulation of Mitochondrial Homeostasis and Nrf2 in Kidney Disease: Timing Is Critical
Y Zhuang, L Hu, Y Wu, C Yang, S Li, K Jing, H Liu, S Flora
Oxidative Medicine & Cellular Longevity 2022
The Role of Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators
L Yin, L Wang, Z Shi, X Ji, L Liu
Frontiers in physiology 2022
Cellular Heterogeneity of the Heart
N Michel, S Ljubojevic-Holzer, H Bugger, A Zirlik
Frontiers in Cardiovascular Medicine 2022
Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration
S Mehan, S Bhalla, E Siddiqui, N Sharma, A Shandilya, A Khan
Degenerative Neurological and Neuromuscular Disease 2022
Cardiac stem cells: Current knowledge and future prospects
Mehanna RA, Essawy MM, Barkat MA, Awaad AK, Thabet EH, Hamed HA, Elkafrawy H, Khalil NA, Sallam A, Kholief MA, Ibrahim SS, Mourad GM
World journal of stem cells 2022
Exploring the Pattern of Metabolic Alterations Causing Energy Imbalance via PPARα Dysregulation in Cardiac Muscle During Doxorubicin Treatment.
Renu K, Vinayagam S, Madhyastha H, Madhyastha R, Maruyama M, Suman S, Arunachalam S, Vellingiri B, Valsala Gopalakrishnan A
Cardiovascular Toxicology 2022
Ultrastructural Changes in Mitochondria in Patients with Dilated Cardiomyopathy and Parvovirus B19 Detected in Heart Tissue without Myocarditis.
Pawlak A, Gewartowska M, Przybylski M, Kuffner M, Wiligórska D, Gil R, Król Z, Frontczak-Baniewicz M
Journal of Personalized Medicine 2022
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance.
Sun D, Wang J, Toan S, Muid D, Li R, Chang X, Zhou H
Angiogenesis 2022
Genomics as a Clinical Decision Support Tool for Identifying and Addressing Modifiable Causes of Cognitive Decline and Improving Outcomes: Proof of Concept Support for This Personalized Medicine Strategy
Hausman-Cohen S, Bilich C, Kapoor S, Maristany E, Stefani A, Wilcox A
Frontiers in aging neuroscience 2022
Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules.
Mahdavi N, Joukar S, Najafipour H, Naderi-Boldaji V
2022
Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway.
Han X, Yang Y, Zhang M, Chu X, Zheng B, Liu C, Xue Y, Guan S, Sun S, Jia Q
Frontiers in pharmacology 2022
PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure.
Chen L, Qin Y, Liu B, Gao M, Li A, Li X, Gong G
Frontiers in Cell and Developmental Biology 2022
Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
Fajardo G, Coronado M, Matthews M, Bernstein D
Biomedicines 2022
Animal Models of Dysregulated Cardiac Metabolism
Bugger H, Byrne NJ, Abel ED
Circulation research 2022
Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate
Persad KL, Lopaschuk GD
Frontiers in Cell and Developmental Biology 2022
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis
Schillemans T, Tragante V, Maitusong B, Gigante B, Cresci S, Laguzzi F, Vikström M, Richards M, Pilbrow A, Cameron V, Foco L, Doughty RN, Kuukasjärvi P, Allayee H, Hartiala JA, Tang WH, Lyytikäinen LP, Nikus K, Laurikka JO, Srinivasan S, Mordi IR, Trompet S, Kraaijeveld A, van Setten J, Gijsberts CM, Maitland-van der Zee AH, Saely CH, Gong Y, Johnson JA, Cooper-DeHoff RM, Pepine CJ, Casu G, Leiherer A, Drexel H, Horne BD, van der Laan SW, Marziliano N, Hazen SL, Sinisalo J, Kähönen M, Lehtimäki T, Lang CC, Burkhardt R, Scholz M, Jukema JW, Eriksson N, Åkerblom A, James S, Held C, Hagström E, Spertus JA, Algra A, de Faire U, Åkesson A, Asselbergs FW, Patel RS, Leander K
Frontiers in physiology 2022
Metabolic Inflexibility as a Pathogenic Basis for Atrial Fibrillation
Qin X, Zhang Y, Zheng Q
International journal of molecular sciences 2022
Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium
Hazim RA, Paniagua AE, Tang L, Yang K, Kim KK, Stiles L, Divakaruni AS, Williams DS
The Journal of biological chemistry 2022
Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis
Pai PY, Wong JK, Cui ZY, Lin YY, Lee SD
Journal of Cardiovascular Development and Disease 2022
Research progress on the pharmacological effects of berberine targeting mitochondria
Fang X, Wu H, Wei J, Miao R, Zhang Y, Tian J
Frontiers in Endocrinology 2022
Quercetin Increases Mitochondrial Biogenesis and Reduces Free Radicals in Neuronal SH-SY5Y Cells
Ho CL, Kao NJ, Lin CI, Cross TW, Lin SH
Nutrients 2022
Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics.
Chen H, Chen C, Spanos M, Li G, Lu R, Bei Y, Xiao J
Signal Transduction and Targeted Therapy 2022
Alterations of Lipid Metabolism in the Heart in Spontaneously Hypertensive Rats Precedes Left Ventricular Hypertrophy and Cardiac Dysfunction
Bednarski TK, Duda MK, Dobrzyn P
Cells 2022
A novel mutation in human EMD gene and mitochondrial dysfunction in emerin knockdown cardiomyocytes
Du Z, Zhu T, Lin M, Bao Y, Qiao J, Lv G, Xie Y, Li Q, Quan J, Xu C, Xie Y, Wang L, Yang W, Wang S, Wu L, Yin T, Xie Y
Journal of Cellular and Molecular Medicine 2022
Stimulating the sir2–spargel axis rescues exercise capacity and mitochondrial respiration in a Drosophila model of Barth syndrome
Damschroder D, Zapata-Pérez R, Richardson K, Vaz FM, Houtkooper RH, Wessells R
Disease models & mechanisms 2022
PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
Tuomainen T, Naumenko N, Mutikainen M, Shakirzyanova A, Sczelecki S, Estall JL, Ruas JL, Tavi P
Cells 2022
PERM1 regulates energy metabolism in the heart via ERRα/PGC−1α axis
Oka SI, Sreedevi K, Shankar TS, Yedla S, Arowa S, James A, Stone KG, Olmos K, Sabry AD, Horiuchi A, Cawley KM, O\u2019very SA, Tong M, Byun J, Xu X, Kashyap S, Mourad Y, Vehra O, Calder D, Lunde T, Liu T, Li H, Mashchek JA, Cox J, Saijoh Y, Drakos SG, Warren JS
Frontiers in Cardiovascular Medicine 2022
Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium
Aggarwal R, Potel KN, McFalls EO, Butterick TA, Kelly RF
Antioxidants 2022
Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury
Li H, Leung JC, Yiu WH, Chan LY, Li B, Lok SW, Xue R, Zou Y, Lai KN, Tang SC
Cell Death and Disease 2022
AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice
Tukhovskaya EA, Shaykhutdinova ER, Pakhomova IA, Slashcheva GA, Goryacheva NA, Sadovnikova ES, Rasskazova EA, Kazakov VA, Dyachenko IA, Frolova AA, Brovkin AN, Kaluzhsky VE, Beburov MY, Murashev AN
International journal of molecular sciences 2022
Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs.
Mukherjee AG, Wanjari UR, Gopalakrishnan AV, Katturajan R, Kannampuzha S, Murali R, Namachivayam A, Ganesan R, Renu K, Dey A, Vellingiri B, Prince SE
Cells 2022
Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy
Su T, Zhang Z, Han X, Yang F, Wang Z, Cheng Y, Liu H
Antioxidants 2022
Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent.
Mendoza M, Mendoza M, Lubrino T, Briski S, Osuji I, Cuala J, Ly B, Ocegueda I, Peralta H, Garcia BA, Zurita-Lopez CI
Biochemistry 2022
Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α
AJ Clark, SM Parikh
Kidney International 2021
Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin
MJ Farshbaf, K Alviña
Frontiers in aging neuroscience 2021
Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
H Chen, X Pan, L Ding, C Ruan, P Gao
Frontiers in Cardiovascular Medicine 2021
Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease
M Zhang, G Wang, T Peng
Cells 2021
Energy metabolism design of the striated muscle cell
B Glancy, RS Balaban
Physiological reviews 2021
Mitochondrial Bioenergetics and Dynamism in the Failing Heart
G Morciano, VA Vitto, E Bouhamida, C Giorgi, P Pinton
Life Sciences 2021
Cardiometabolism as an Interlocking Puzzle between the Healthy and Diseased Heart: New Frontiers in Therapeutic Applications
T Pasqua, C Rocca, A Giglio, T Angelone
Journal of Clinical Medicine 2021
GCN5 acetyltransferase in cellular energetic and metabolic processes
B Mutlu, P Puigserver
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2021
Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
BB Brandão, A Poojari, A Rabiee
International journal of molecular sciences 2021
Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart
H Du, Y Zhao, H Li, DW Wang, C Chen
Frontiers in Cardiovascular Medicine 2021
Control of cardiomyocyte differentiation timing by intercellular signaling pathways
M Rowton, A Guzzetta, AB Rydeen, IP Moskowitz
Seminars in Cell & Developmental Biology 2021
Decreased PGC1β expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit
T Sen, J Chen, S Singbrant
Scientific Reports 2021
Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation
S Chiang, N Braidy, S Maleki, S Lal, DR Richardson, ML Huang
Redox Biology 2021
Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities
LJ McMeekin, SN Fox, SM Boas, RM Cowell
Cells 2021
Physical Exercise: A Novel Tool to Protect Mitochondrial Health
D Sorriento, ED Vaia, G Iaccarino
Frontiers in physiology 2021
Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
JM Reyes, R Cuesta, A Pause
Frontiers in Cell and Developmental Biology 2021
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality
J Lasheras, R Pardo, M Velilla, M Poncelas, N Salvatella, R Simó, M Ruiz-Meana, M Zamora, JA Villena
International journal of molecular sciences 2021
The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction
M Federico, SD la Fuente, J Palomeque, SS Sheu
The Journal of Physiology 2021
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
F Guo, M Seldin, M Péterfy, S Charugundla, Z Zhou, SD Lee, A Mouton, P Rajbhandari, W Zhang, M Pellegrini, P Tontonoz, AJ Lusis, DM Shih
Scientific Reports 2021
Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the Western World?
F Kolodziej, KD OHalloran
Antioxidants 2021
Effects of Hyperoxia on Mitochondrial Homeostasis: Are Mitochondria the Hub for Bronchopulmonary Dysplasia?
Y Xuefei, Z Xinyi, C Qing, Z Dan, L Ziyun, Z Hejuan, X Xindong, F Jianhua
Frontiers in Cell and Developmental Biology 2021
Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell–Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium
G Ikeda, MR Santoso, Y Tada, AM Li, E Vaskova, JH Jung, C OBrien, E Egan, J Ye, PC Yang
Journal of the American College of Cardiology 2021
The Use of Antioxidants as Potential Co-Adjuvants to Treat Chronic Chagas Disease
E Maldonado, DA Rojas, F Urbina, A Solari
Antioxidants 2021
Endocrine Influence on Cardiac Metabolism in Development and Regeneration
N Graham, GN Huang
Endocrinology 2021
Identification and host response interaction study of SARS-CoV-2 encoded miRNA-like sequences: an in silico approach
S Roy, B Sharma, I Mazid, RN Akhand, M Das, M Marufatuzzahan, TA Chowdhury, KF Azim, M Hasan
Computers in Biology and Medicine 2021
Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction
C Yang, K Zhao, X Chen, L Jiang, P Li, P Huang
Amino Acids 2021
Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha
H Yan, H Wang, X Zhu, J Huang, Y Li, K Zhou, Y Hua, F Yan, DZ Wang, Y Luo
Molecular Therapy — Nucleic Acids 2021
Heart Metabolism in Sepsis-Induced Cardiomyopathy—Unusual Metabolic Dysfunction of the Heart
W Wasyluk, P Nowicka-Stążka, A Zwolak
International journal of environmental research and public health 2021
Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities
PN Zhang, MQ Zhou, J Guo, HJ Zheng, J Tang, C Zhang, YN Liu, WJ Liu, YX Wang, AL Hui
Journal of Diabetes Research 2021
Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications
J McClung, L Levy, V Garcia, D Stec, S Peterson, N Abraham
Pharmacology & Therapeutics 2021
Maturation of Stem Cell-Derived Cardiomyocytes: Foe in Translation Medicine.
Liao Y, Zhu L, Wang Y
International journal of stem cells 2021
The effect of curculigo orchioides (Xianmao) on kidney energy metabolism and the related mechanism in rats based on metabolomics.
Chen L, Qu B, Wang H, Liu H, Guan Y, Zhou J, Zhang J
Food Science & Nutrition 2021
Changes in Cardiac Metabolism in Prediabetes.
de Wit-Verheggen VHW, van de Weijer T
Biomolecules 2021
Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake.
Trinchese G, Cimmino F, Cavaliere G, Rosati L, Catapano A, Sorriento D, Murru E, Bernardo L, Pagani L, Bergamo P, Scudiero R, Iaccarino G, Greco L, Banni S, Crispino M, Mollica MP
2021
Mitochondrial Biogenesis in Neurons: How and Where.
Cardanho-Ramos C, Morais VA
International journal of molecular sciences 2021
Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice.
Yeh CC, Liu HM, Lee MC, Leu YL, Chiang WH, Chang HH, Lee TY
Molecular medicine reports 2021
Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration.
Wen S, Unuma K, Funakoshi T, Aki T, Uemura K
Scientific Reports 2021
The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential
Zhang X, Zhang Y, Sun A, Ge J
Genes & Diseases 2021
Synergistic Effects of Exercise Training and Vitamin D Supplementation on Mitochondrial Function of Cardiac Tissue, Antioxidant Capacity, and Tumor Growth in Breast Cancer in Bearing-4T1 Mice.
Jafari A, Sheikholeslami-Vatani D, Khosrobakhsh F, Khaledi N
Frontiers in physiology 2021
The mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review).
Ke L, Li Q, Song J, Jiao W, Ji A, Chen T, Pan H, Song Y
Experimental and therapeutic medicine 2021
Decreased Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Impairs Angiogenesis in a Lamb Model of Persistent Pulmonary Hypertension of the Newborn.
Sharma M, Rana U, Joshi C, Michalkiewicz T, Afolayan A, Parchur A, Joshi A, Teng RJ, Konduri GG
American journal of respiratory cell and molecular biology 2021
Glucocorticoid maturation of mitochondrial respiratory capacity in skeletal muscle before birth.
Davies KL, Camm EJ, Smith DJ, Vaughan OR, Forhead AJ, Murray AJ, Fowden AL
The Journal of endocrinology 2021
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O\u2019Rourke B, Kass DA, Takimoto E
FEBS Letters 2021
Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy
Collins HE, Kane MS, Litovsky SH, Darley-Usmar VM, Young ME, Chatham JC, Zhang J
2021
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
Wang L, Li J, Di L
Medicinal Research Reviews 2021
Metabolic Crosstalk between the Heart and Fat
KM Ferrero, WJ Koch
Korean Circulation Journal 2020
Targeting the Mitochondria in Heart Failure
HN Sabbah
JACC: Basic to Translational Science 2020
Dysregulated metabolic pathways in age-related macular degeneration
M Zhang, N Jiang, Y Chu, O Postnikova, R Varghese, A Horvath, AK Cheema, N Golestaneh
Scientific Reports 2020
Multiple Levels of PGC-1α Dysregulation in Heart Failure
S Oka, AD Sabry, KM Cawley, JS Warren
Frontiers in Cardiovascular Medicine 2020
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
T Sakamoto, TR Matsuura, S Wan, DM Ryba, J Kim, KJ Won, L Lai, C Petucci, N Petrenko, K Musunuru, RB Vega, DP Kelly
Circulation research 2020
Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin
JM Quiles, ÅB Gustafsson
Frontiers in physiology 2020
ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation
S Müller, A Perdikari, DH Dapito, W Sun, B Wollscheid, M Balaz, C Wolfrum
Frontiers in Endocrinology 2020
Energy Metabolism in Exercise-Induced Physiologic Cardiac Hypertrophy
K Xiang, Z Qin, H Zhang, X Liu
Frontiers in pharmacology 2020
Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation
KH Yap, GS Yee, M Candasamy, SC Tan, Shadab, AB Majeed, SK Bhattamisra
Biomolecules 2020
PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator
JM Chambers, RA Wingert
Cells 2020
Fetal cardiomyocyte phenotype, ketone body metabolism, and mitochondrial dysfunction in the pathology of atrial fibrillation
SM Brown, NK Larsen, FG Thankam, DK Agrawal
Molecular and Cellular Biochemistry 2020
Control of Adipose Cell Browning and Its Therapeutic Potential
F Lizcano, F Arroyave
Metabolites 2020
The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPARα and PPARγ Activation
C Kalliora, K Drosatos
Journal of Cardiovascular Pharmacology 2020
Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways That Regulate Cardiac Metabolism and Cell Fate in Newborn Rat Hearts
CC Preston, TD Larsen, JA Eclov, EJ Louwagie, TC Gandy, RS Faustino, ML Baack
Frontiers in Endocrinology 2020
Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men
E Maseroli, P Comeglio, C Corno, I Cellai, S Filippi, T Mello, A Galli, E Rapizzi, L Presenti, MC Truglia, F Lotti, E Facchiano, B Beltrame, M Lucchese, F Saad, G Rastrelli, M Maggi, L Vignozzi
Journal of Endocrinological Investigation 2020
Beige Fat Maintenance; Toward a Sustained Metabolic Health
A Rabiee
Frontiers in Endocrinology 2020
Androgen-Regulated Cardiac Metabolism in Aging Men
G Barrientos, P Llanos, C Basualto-Alarcón, M Estrada
Frontiers in Endocrinology 2020
Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis
X Qin, M Jiang, Y Zhao, J Gong, H Su, F Yuan, K Fang, X Yuan, X Yu, H Dong, F Lu
British Journal of Pharmacology 2020
The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
M Waldman, M Arad, NG Abraham, E Hochhauser
Antioxidants & Redox Signaling 2020
The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia
J Li, Y Li, MM Atakan, J Kuang, Y Hu, DJ Bishop, X Yan
Antioxidants 2020
Mitochondrial Quality Control in Cardiomyocytes: A Critical Role in the Progression of Cardiovascular Diseases
H Fan, Z He, H Huang, H Zhuang, H Liu, X Liu, S Yang, P He, H Yang, D Feng
Frontiers in physiology 2020
Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging
R Lin, R Kerkelä
International journal of molecular sciences 2020
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1
S Oka, AD Sabry, AK Horiuchi, KM Cawley, SA OVery, MA Zaitsev, TS Shankar, J Byun, R Mukai, X Xu, NS Torres, A Kumar, M Yazawa, J Ling, I Taleb, Y Saijoh, SG Drakos, J Sadoshima, JS Warren, T Minamino
PloS one 2020
PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells
Y Liu, H Bai, F Guo, PN Thai, X Luo, P Zhang, C Yang, X Feng, D Zhu, J Guo, P Liang, Z Xu, H Yang, X Lu
Aging 2020
Identification and Annotation of Potential Function of Regulatory Antisense Long Non-Coding RNAs Related to Feed Efficiency in Bos taurus Bulls
W Nolte, R Weikard, RM Brunner, E Albrecht, HM Hammon, A Reverter, C Kühn
International journal of molecular sciences 2020
A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway
SM Asokan, T Wang, MF Wang, WT Lin
Aging 2020
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
R Fukuda, R MarínJuez, H ElSammak, A Beisaw, R Ramadass, C Kuenne, S Guenther, A Konzer, AM Bhagwat, J Graumann, DY Stainier
EMBO reports 2020
Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells
S Elesela, SB Morris, S Narayanan, S Kumar, DB Lombard, NW Lukacs, PG Thomas
PLoS pathogens 2020
Protective Effect of L-Hexaguluroic Acid Hexasodium Salt on UVA-Induced Photo-Aging in HaCaT Cells.
Li Q, Bai D, Qin L, Shao M, Liu X, Zhang S, Yan C, Yu G, Hao J
International journal of molecular sciences 2020
Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions.
Han YM, Lee YJ, Jang YN, Kim HM, Seo HS, Jung TW, Jeong JH
BioMed Research International 2020
Changes in Serum Levels and Gene Expression of PGC-1α in The Cardiac Muscle of Diabetic Rats: The Effect of Dichloroacetate and Endurance Training.
Rezaei Nasab H, Habibi AH, Nikbakht M, Rashno M, Shakerian S
2020
Changes in PGC-1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model.
Panes JD, Godoy PA, Silva-Grecchi T, Celis MT, Ramirez-Molina O, Gavilan J, Muñoz-Montecino C, Castro PA, Moraga-Cid G, Yévenes GE, Guzmán L, Salisbury JL, Trushina E, Fuentealba J
Frontiers in pharmacology 2020
Age‑related changes in mineralocorticoid receptors in rat hearts.
Hu D, Dong R, Zhang Y, Yang Y, Chen Z, Tang Y, Fu M, Xu X, Tu L
Molecular medicine reports 2020
Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice.
Diao Y, Nie J, Tan P, Zhao Y, Zhao T, Tu J, Ji H, Cao Y, Wu Z, Liang H, Huang H, Li Y, Gao X, Zhou L
Aging 2020
Modulatory Effects of Chinese Herbal Medicines on Energy Metabolism in Ischemic Heart Diseases.
Li F, Li J, Li S, Guo S, Li P
Frontiers in pharmacology 2020
Higher Lactate Level and Lactate-to-Pyruvate Ratio in Autism Spectrum Disorder.
Oh M, Kim SA, Yoo HJ
Experimental Neurobiology 2020
PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
Mukherjee D, Chander V, Bandyopadhyay A
Molecular and cellular biology 2020
Dual Peroxisome-Proliferator-Activated-Receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
Charikleia Kalliora, Ioannis Kyriazis, Shin-ichi Oka, Melissa J. Lieu, Yujia Yue, Estela Area-Gomez, Christine J Pol, Ying Tian, Wataru Mizushima, Adave Chin, Diego Scerbo, Christian Schulze, Mete Civelek, Junichi Sadoshima, Mumiswamy Madesh, Ira Goldberg, Konstantinos Drosatos
JCI Insight 2019
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
Julie L. Horton, Michael T Davidson, Clara Kurishima, Rick B Vega, Jeffery Powers, Timothy R Matsuura, Christopher Petucci, E. Douglas Lewandowski, Peter A. Crawford, Deborah M. Muoio, Fabio A. Recchia, Daniel P. Kelly
JCI Insight 2019
PGC‐1α, a potential therapeutic target against kidney aging
G Lee, J Uddin, Y Kim, M Ko, I Yu, H Ha
Aging Cell 2019
MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
Z Yin, Y Zhao, M He, H Li, J Fan, X Nie, M Yan, C Chen, DW Wang
Cardiovascular Diabetology 2019
Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases
J Lv, C Deng, S Jiang, T Ji, Z Yang, Z Wang, Y Yang
Theranostics 2019
A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice
C Carmody, AN Ogawa-Wong, C Martin, C Luongo, M Zuidwijk, B Sager, T Petersen, AR Guetter, R Janssen, EY Wu, S Bogaards, NM Neumann, K Hau, A Marsili, A Boelen, JE Silva, M Dentice, D Salvatore, AJ Wagers, PR Larsen, WS Simonides, AM Zavacki
Endocrinology 2019
The secret messages between mitochondria and nucleus in muscle cell biology
RB Soledad, S Charles, D Samarjit
Archives of Biochemistry and Biophysics 2019
Metabolic flux analyses to assess the differentiation of adult cardiac progenitors after fatty acid supplementation
S Malandraki-Miller, CA Lopez, R Alonaizan, U Purnama, F Perbellini, K Pakzad, CA Carr
Stem Cell Research 2019
Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway
C Liu, J Ma, J Zhang, H Zhao, Y Zhu, J Qi, L Liu, L Zhu, Y Jiang, G Tang, X Li, M Li
Frontiers in Genetics 2019
Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge
S Khan, J Roberts, SB Wu
2019
PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells
J Cao, , D Wang, R Ma, X Li, H Feng, J Wang, S Liu, L Wang
Cancer Cell International 2019
Protein composition of the muscle mitochondrial reticulum during postnatal development
Y Kim, DS Yang, P Katti, B Glancy
The Journal of Physiology 2019
SR Ca 2+ leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance
N Ivarsson, CM Mattsson, AJ Cheng, JD Bruton, B Ekblom, JT Lanner, H Westerblad
The Journal of General Physiology 2019
A comparative analysis of the transcriptome profiles of liver and muscle tissue in pigs divergent for feed efficiency
S Vigors, JV ODoherty, K Bryan, T Sweeney
BMC Genomics 2019
Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model
J George, HT Jacobs
Biology Open 2019
Immunometabolic cross-talk in the inflamed heart
FM Marelli-Berg, D Aksentijevic
2019
Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
K Khetchoumian, A Balsalobre, A Mayran, H Christian, V Chénard, J St-Pierre, J Drouin
Nature Communications 2019
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
X Zhu, W Shen, K Yao, H Wang, B Liu, T Li, L Song, D Diao, G Mao, P Huang, C Li, H Zhang, Y Zou, Y Qiu, Y Zhao, W Wang, Y Yang, Z Hu, J Auwerx, J Loscalzo, Y Zhou, Z Ju
Circulation research 2019
Metabolic remodeling induced by mitokines in heart failure
J Duan, Z Chen, Y Wu, B Zhu, L Yang, C Yang
Aging 2019
PPARA genetic variants increase the risk for cardiac pumping function reductions following acute high‐altitude exposure: A self‐controlled study
J Yang, C Liu, Z Jihang, J Yu, L Dai, X Ding, Y Qiu, S Yu, Y Yang, Y Wu, L Huang
Molecular Genetics & Genomic Medicine 2019
Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway
GX Mao, XG Xu, SY Wang, HF Li, J Zhang, ZS Zhang, HL Su, SS Chen, WM Xing, YZ Wang, JH Dai, GF Wang, SX Leng, J Yan
Oxidative medicine and cellular longevity 2019
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats
M Gu, P He, C Lyu, X Liu, Y Xu, S Cheng, Y Gu, Y Jia
Molecular medicine reports 2019
Limited predictive value of TFAM in mitochondrial biogenesis
N Kozhukhar, MF Alexeyev
Mitochondrion 2019
Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling
X Li, LL Ballantyne, Y Yu, CD Funk
The FASEB Journal 2019
Determinants of Cardiac Growth and Size
TR Heallen, ZA Kadow, J Wang, JF Martin
Cold Spring Harbor perspectives in biology 2019
Metabolic Alterations in Inherited Cardiomyopathies
C Sacchetto, V Sequeira, E Bertero, J Dudek, C Maack, M Calore
Journal of Clinical Medicine 2019
Enhanced mitochondrial biogenesis is associated with the ameliorative action of creatine supplementation in rat soleus and cardiac muscles
M Gowayed, S Mahmoud, Y ElSayed, N AbuSamra, M Kamel
Experimental and therapeutic medicine 2019
Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model.
Collins MM, Ahlberg G, Hansen CV, Guenther S, Marín-Juez R, Sokol AM, El-Sammak H, Piesker J, Hellsten Y, Olesen MS, Stainier DYR, Lundegaard PR
Proceedings of the National Academy of Sciences 2019
The Role of Myocardial Mitochondrial Quality Control in Heart Failure.
Qiu Z, Wei Y, Song Q, Du B, Wang H, Chu Y, Hu Y
Frontiers in pharmacology 2019
Acetylation Contributes to Hypertrophy-Caused Maturational Delay of Cardiac Energy Metabolism
Arata Fukushima, Liyan Zhang, Alda Huqi, Victoria Lam, Sonia Rawat, Tariq Altamimi, Cory Wagg, Khushmol Dhaliwal, Lisa K. Hornberger, Paul Kantor, Ivan Rebeyka, Gary Lopaschuk
JCI Insight 2018
Effects and mechanisms of apolipoprotein A-V on the regulation of lipid accumulation in cardiomyocytes
J Luo, L Xu, J Li, S Zhao
Lipids in Health and Disease 2018
Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics
DC Zank, M Bueno, AL Mora, M Rojas
Frontiers in Medicine 2018
PGC1α in the kidney
MR Lynch, MT Tran, SM Parikh
American journal of physiology. Renal physiology 2018
Nitric oxide signalling in cardiovascular health and disease
C Farah, LY Michel, JL Balligand
Nature Reviews Cardiology 2018
The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells
C Hoffmann, S Höckele, L Kappler, MH de Angelis, HU Häring, C Weigert
Scientific Reports 2018
Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart
N Whitehead, JF Gill, M Brink, C Handschin
Frontiers in physiology 2018
Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity
J Zhang, M Wang, R Wang, X Sun, Y Du, J Ye, G Sun, X Sun
Frontiers in pharmacology 2018
PGC1α: Friend or Foe in Cancer?
F Mastropasqua, G Girolimetti, M Shoshan
Genes & development 2018
Tissue specificity of mitochondrial adaptations in rats after 4 weeks of normobaric hypoxia
A Ferri, A Panariti, G Miserocchi, M Rocchetti, GB Comani, I Rivolta, DJ Bishop
European Journal of Applied Physiology 2018
Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes
BM Ulmer, A Stoehr, ML Schulze, S Patel, M Gucek, I Mannhardt, S Funcke, E Murphy, T Eschenhagen, A Hansen
Stem Cell Reports 2018
KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts
KS Seo, JH Kim, KN Min, JA Moon, TC Roh, MJ Lee, KW Lee, JE Min, YM Lee
Frontiers in neurology 2018
Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver
P Dongil, A Pérez-García, V Hurtado-Carneiro, C Herrero-de-Dios, E Blazquez, E Alvarez, C Sanz
Scientific Reports 2018
Multiscale structure-function relationships in right ventricular failure due to pressure overload
TC Cheng, JL Philip, DM Tabima, TA Hacker, NC Chesler
American journal of physiology. Heart and circulatory physiology 2018
Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
S Pickles, P Vigié, RJ Youle
Current biology : CB 2018
Maturation of Cardiac Energy Metabolism During Perinatal Development
J Piquereau, R Ventura-Clapier
Frontiers in physiology 2018
Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells
A Parousis, HN Carter, C Tran, AT Erlich, ZS Moosavi, M Pauly, DA Hood
Autophagy 2018
Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart
JS Warren, CM Tracy, MR Miller, A Makaju, MW Szulik, S Oka, TN Yuzyuk, JE Cox, A Kumar, BK Lozier, L Wang, JG Llana, AD Sabry, KM Cawley, DW Barton, YH Han, S Boudina, O Fiehn, HO Tucker, AV Zaitsev, S Franklin
Proceedings of the National Academy of Sciences 2018
Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls
M Weihrauch, C Handschin
Biochemical Pharmacology 2018
Changing Metabolism in Differentiating Cardiac Progenitor Cells—Can Stem Cells Become Metabolically Flexible Cardiomyocytes?
S Malandraki-Miller, CA Lopez, H Al-Siddiqi, CA Carr
Frontiers in Cardiovascular Medicine 2018
The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
XM Caravia, V Fanjul, E Oliver, D Roiz-Valle, A Morán-Álvarez, G Desdín-Micó, M Mittelbrunn, R Cabo, JA Vega, F Rodríguez, A Fueyo, M Gómez, M Lobo-González, H Bueno, G Velasco, JM Freije, V Andrés, B Ibáñez, AP Ugalde, C López-Otín, C Lo
PLoS Biology 2018
PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation
CF Cheng, HC Ku, H Lin
International journal of molecular sciences 2018
Transcriptional Control of Brown and Beige Fat Development and Function: Beige Fat Development and Function
SN Shapira, P Seale
Obesity 2018
Mitochondrial membrane transporters and metabolic switch in heart failure
V Kumar, TR Kumar, CC Kartha
Heart Failure Reviews 2018
An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle
PS Oliveira, LL Coutinho, PC Tizioto, AS Cesar, GB de Oliveira, WJ da S. Diniz, AO Lima, JM Reecy, GB Mourão, A Zerlotini, LC Regitano
Scientific Reports 2018
Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
WK Chen, YL Tsai, MA Shibu, CY Shen, SN Chang-Lee, RJ Chen, CH Yao, B Ban, WW Kuo, CY Huang
Aging 2018
Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
I Bruns, B Sauer, MC Burger, J Eriksson, U Hofmann, Y Braun, PN Harter, AL Luger, MW Ronellenfitsch, JP Steinbach, J Rieger
The Journal of biological chemistry 2018
PGC-1α activation: a therapeutic target for type 2 diabetes?
D Yuan, D Xiao, Q Gao, L Zeng
Eating and weight disorders : EWD 2018
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons.
Godoy JA, Valdivieso AG, Inestrosa NC
Molecular Neurobiology 2018
Cardiac Nuclear Receptors: Architects of Mitochondrial Structure and Function
Rick B. Vega, Daniel P. Kelly
Journal of Clinical Investigation 2017
Increasing the level of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 α in podocytes results in collapsing glomerulopathy
Szu-yuan Li, Jihwan Park, Chengxiang Qiu, Seung Hyeok Han, Matthew B. Palmer, Zoltan Arany, Katalin Susztak
JCI Insight 2017
Metabolic reprogramming and tolerance during sepsis-induced AKI
H Gómez, JA Kellum, C Ronco
Nature Reviews Nephrology 2017
Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells
T Hatsukano, J Kurisu, K Fukumitsu, K Fujishima, M Kengaku
Frontiers in cellular neuroscience 2017
Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type 2 Diabetes
P Devarshi, S McNabney, T Henagan
International journal of molecular sciences 2017
Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse: Leptin and cardiac dysfunction
N Gómez-Hurtado, A Domínguez-Rodríguez, P Mateo, M Fernández-Velasco, A Val-Blasco, R Aizpún, J Sabourin, AM Gómez, JP Benitah, C Delgado
The Journal of Physiology 2017
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
MS Lee, Y Shin, S Jung, Y Kim
Food & Nutrition Research 2017
PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
HI Choi, HJ Kim, JS Park, IJ Kim, EH Bae, SK Ma, SW Kim
Scientific Reports 2017
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis
XY Guo, CX He, YQ Wang, C Sun, GM Li, Q Su, Q Pan, JG Fan
BioMed Research International 2017
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway
K Bernard, NJ Logsdon, V Miguel, GA Benavides, J Zhang, AB Carter, VM Darley-Usmar, VJ Thannickal
The Journal of biological chemistry 2017
A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling
L Schirone, M Forte, S Palmerio, D Yee, C Nocella, F Angelini, F Pagano, S Schiavon, A Bordin, A Carrizzo, C Vecchione, V Valenti, I Chimenti, ED Falco, S Sciarretta, G Frati
Oxidative medicine and cellular longevity 2017
Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice
JM Quiles, M Narasimhan, G Shanmugam, B Milash, JR Hoidal, NS Rajasekaran
BMC Genomics 2017
The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control
RR Wang, R Pan, W Zhang, J Fu, JD Lin, ZX Meng
Protein & Cell 2017
SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells
P Li, Y Liu, N Burns, KS Zhao, R Song
International journal of molecular medicine 2017
Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
C Correia, A Koshkin, P Duarte, D Hu, A Teixeira, I Domian, M Serra, PM Alves
Scientific Reports 2017
Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ
GC Rowe, A Asimaki, EL Graham, KD Martin, KB Margulies, S Das, J Saffitz, Z Arany
American journal of physiology. Heart and circulatory physiology 2017
Involvement of Mitochondrial Disorders in Septic Cardiomyopathy
A Durand, T Duburcq, T Dekeyser, R Neviere, M Howsam, R Favory, S Preau
Oxidative medicine and cellular longevity 2017
Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice
S Lee, TC Leone, L Rogosa, J Rumsey, J Ayala, PM Coen, RH Fitts, RB Vega, DP Kelly
American journal of physiology. Endocrinology and metabolism 2017
Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming
KM Spitler, JM Ponce, GY Oudit, DD Hall, CE Grueter
American journal of physiology. Heart and circulatory physiology 2017
Molecular, neuromuscular, and recovery responses to light versus heavy resistance exercise in young men
CT Haun, PW Mumford, PA Roberson, MA Romero, CB Mobley, WC Kephart, RG Anderson, RJ Colquhoun, TW Muddle, MJ Luera, CS Mackey, DD Pascoe, KC Young, JS Martin, JM DeFreitas, ND Jenkins, MD Roberts
Physiological Reports 2017
PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level
L Zhu, Q Huang, Z Xie, M Kang, H Ding, B Chen, Y Chen, C Liu, Y Wang, W Tang
Oncotarget 2017
PGC-1 α Protects from Notch-Induced Kidney Fibrosis Development
SH Han, M Wu, BY Nam, JT Park, TH Yoo, SW Kang, J Park, F Chinga, SY Li, K Susztak
Journal of the American Society of Nephrology : JASN 2017
Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts
H Valli, S Ahmad, KR Chadda, AB Al-Hadithi, AA Grace, K Jeevaratnam, CL Huang
Mechanisms of Ageing and Development 2017
Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling
AH Chaanine, KS Nair, RH Bergen, K Klaus, AJ Guenzel, RJ Hajjar, MM Redfield
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2017
The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues
E Supruniuk, A Mikłosz, A Chabowski
Frontiers in physiology 2017
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial FissionNovelty and Significance
K Tsushima, H Bugger, AR Wende, J Soto, GA Jenson, AR Tor, R McGlauflin, HC Kenny, Y Zhang, R Souvenir, XX Hu, CL Sloan, RO Pereira, VA Lira, KW Spitzer, TL Sharp, KI Shoghi, GC Sparagna, EA Rog-Zielinska, P Kohl, O Khalimonchuk, JE Schaffer, ED Abel
Circulation research 2017
LncRNA Tug1 Regulates Mitochondrial Bioenergetics in Diabetic Nephropathy
Jianyin Long, Shawn Badal, Zengchun Ye, Yin Wang, Bernard Ayanga, Daniel Galvan, Nathanael Green, Benny Chang, Paul A. Overbeek, Farhad R. Danesh
Journal of Clinical Investigation 2016
Molecular Profiling of Dilated Cardiomyopathy that Progresses to Heart Failure
Michael Burke, Stephen Chang, Hiroko Wakimoto, Joshua Gorham, David Conner, Danos Christodoulou, Michael Parfenov, Steven DePalma, Seda Eminaga, Tetsuo Konno, Jonathan Seidman, Christine Seidman
JCI Insight 2016
PGC-1α1 induces cardiac excitation-contraction coupling phenotype without metabolic remodelling
M Mutikainen, T Tuomainen, N Naumenko, J Huusko, B Smirin, S Laidinen, K Kokki, H Hynynen, S Ylä-Herttuala, M Heinäniemi, JL Ruas, P Tavi
The Journal of Physiology 2016
Mitochondrial remodeling: Rearranging, recycling, and reprogramming
RA Gottlieb, D Bernstein
Cell Calcium 2016
The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms
J Roh, J Rhee, V Chaudhari, A Rosenzweig
Circulation research 2016
Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders
KH Su, C Dai
Cellular and Molecular Life Sciences 2016
Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis
KE Cunningham, G Vincent, CP Sodhi, EA Novak, S Ranganathan, CE Egan, DB Stolz, MB Rogers, B Firek, MJ Morowitz, GK Gittes, BS Zuckerbraun, DJ Hackam, KP Mollen
The Journal of biological chemistry 2016
Regulation of myoglobin in hypertrophied rat cardiomyocytes in experimental pulmonary hypertension
EL Peters, C Offringa, D Kos, WJ van der Laarse, RT Jaspers
Pflügers Archiv - European Journal of Physiology 2016
Mitochondrial quality control in the diabetic heart
Q Liang, S Kobayashi
Journal of Molecular and Cellular Cardiology 2016
Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro
E Matsa, PW Burridge, KH Yu, JH Ahrens, V Termglinchan, H Wu, C Liu, P Shukla, N Sayed, JM Churko, N Shao, NA Woo, AS Chao, JD Gold, I Karakikes, MP Snyder, JC Wu
Cell Stem Cell 2016
ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones
T Masuda, Y Wada, S Kawamura
Scientific Reports 2016
The effects of acute cold exposure on morphology and gene expression in the heart of neonatal chicks
T Matsubara, S Shimamoto, D Ijiri, A Ohtsuka, Y Kanai, M Hirabayashi
Journal of Comparative Physiology B 2016
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation: ( A ) Human BJ iPSC-derived NPCs showed homogeneous expression of the NPC markers Nestin and Sox2. ( B ) The left panel shows NPC-derived neurons after 3 weeks of differentiation; right panel shows staining of MAP2, a neuronal marker. ( C ) The top 200 up- and down-regulated genes during neuronal differentiation are depicted by a heatmap. Red and green intensities indicate fold increases and decreases, respectively, in gene expression (expressed as log2). ( D ) GO term analysis of genes up-regulated during neuronal differentiation. The top eight GO term biological process categories obtained are ranked by p-value. ( E ) The FPKM values of known neuron-specific genes are shown as log10-fold change. ( F ) The fold changes of FPKM values of proliferating NPC markers are shown. Bars represent mean ± SD of four RNA-seq replicates for NPCs and neurons differentiated at 1 and 3 weeks. ( G , H , I and J ) Relative expression levels of the key metabolic genes in glycolysis, tricarboxylic acid cycle (TCA), pyruvate dehydrogenase (PDH) complex and pentose phosphate pathway. Bars show the mean of FPKM values of differentiated neurons at 1 and 3 weeks relative to FPKM values of NPCs. Error bars represent SD of four RNA-seq replicates at each time point. Abbreviations, dihydroxyacetone phosphate (DHAP); 1,3-bisphosphoglyceric acid (1,3 BPG); 3-phosphoglyceric acid (3PG); phosphoenolpyruvic acid (PEP), α-ketoglutarate (α-KG); oxaloacetate (OAA). (Figure 1—sourcer data 1)
X Zheng, L Boyer, M Jin, J Mertens, Y Kim, L Ma, L Ma, M Hamm, FH Gage, T Hunter
eLife 2016
A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain
R Bakshi, S Mittal, Z Liao, CR Scherzer
Parkinson's Disease 2016
MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells
KD Chen, KT Huang, CC Lin, WT Weng, LW Hsu, S Goto, T Nakano, CY Lai, CP Kung, KW Chiu, CC Wang, YF Cheng, YY Ma, CL Chen
Molecular Therapy — Nucleic Acids 2016
Endothelial Restoration of Receptor Activity–Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated CardiomyopathyNovelty and Significance
DO Kechele, WP Dunworth, CE Trincot, SE Wetzel-Strong, M Li, H Ma, J Liu, KM Caron
Hypertension 2016
Mitochondria are required for pro‐ageing features of the senescent phenotype
C CorreiaMelo, FD Marques, R Anderson, G Hewitt, R Hewitt, J Cole, BM Carroll, S Miwa, J Birch, A Merz, MD Rushton, M Charles, D Jurk, SW Tait, R Czapiewski, L Greaves, G Nelson, M BohloolyY, S RodriguezCuenca, A VidalPuig, D Mann, G Saretzki, G Quarato, DR Green, PD Adams, T Zglinicki, VI Korolchuk, JF Passos
The EMBO Journal 2016
Skeletal muscle bioenergetics in aging and heart failure
SZ Liu, DJ Marcinek
Heart Failure Reviews 2016
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure
DA Brown, JB Perry, ME Allen, HN Sabbah, BL Stauffer, SR Shaikh, JG Cleland, WS Colucci, J Butler, AA Voors, SD Anker, B Pitt, B Pieske, G Filippatos, SJ Greene, M Gheorghiade
Nature Reviews Cardiology 2016
The effect of Chinese herbs and its effective components on coronary heart disease through PPARs-PGC1α pathway
Q Wang, C Li, Q Zhang, Y Wang, T Shi, L Lu, Y Zhang, Y Wang, W Wang
BMC complementary and alternative medicine 2016
Role of microRNA in metabolic shift during heart failure
MV Pinti, QA Hathaway, JM Hollander
American journal of physiology. Heart and circulatory physiology 2016
Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C 2 C 12 Muscle Cells
MS Lee, Y Shin, S Moon, S Kim, Y Kim
Preventive Nutrition and Food Science 2016
The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging
S Aghaei, MA Nilforoushzadeh, M Aghaei
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2016
Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View.
Filograna R, Beltramini M, Bubacco L, Bisaglia M
Current neuropharmacology 2016
Transcriptional Control of Cardiac Mitochondrial Homeostasis by KLF4
Xudong Liao, Rongli Zhang, Yuan Lu, Domenick A. Prosdocimo, Panjamaporn Sangwung, lilei zhang, guangjin zhou, Puneet Anand, Ling Lai, Teresa C. Leone, Hisashi Fujioka, Fang Ye, Mariana Rosca, Charles Hoppel, P. Christian Schulze, E. Dale Abel, Jonathan S. Stamler, Daniel P. Kelly, Mukesh Jain
Journal of Clinical Investigation 2015
Muscle as a “Mediator” of Systemic Metabolism
KK Baskin, BR Winders, EN Olson
Cell Metabolism 2015
Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload
A Elezaby, AL Sverdlov, VH Tu, K Soni, I Luptak, F Qin, M Liesa, OS Shirihai, J Rimer, JE Schaffer, CW S., ME J.
2015
Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart
IA Bollen, ED van Deel, DW Kuster, JV der Velden
Frontiers in physiology 2015
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
T Had i , D Park, KC Abruzzi, L Yang, JS Trigg, R Rohs, M Rosbash, PH Taghert
Nucleic Acids Research 2015
Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
AK Cheema, T Li, JP Liuzzi, GG Zarini, MT Dorak, FG Huffman
Journal of Diabetes Research 2015
Effects of Maternal Diet and Exercise during Pregnancy on Glucose Metabolism in Skeletal Muscle and Fat of Weanling Rats
M Raipuria, H Bahari, MJ Morris, C Torrens
PloS one 2015
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-  Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1  and Mitochondrial Homeostasis
Y Wang, Y Cao, S Yamada, M Thirunavukkarasu, V Nin, M Joshi, MT Rishi, S Bhattacharya, J Camacho-Pereira, AK Sharma, K Shameer, JP Kocher, JA Sanchez, E Wang, LH Hoeppner, SK Dutta, EB Leof, V Shah, KP Claffey, EN Chini, M Simons, A Terzic, N Maulik, D Mukhopadhyay
Arteriosclerosis, thrombosis, and vascular biology 2015
Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes
KT Kuppusamy, DC Jones, H Sperber, A Madan, KA Fischer, ML Rodriguez, L Pabon, WZ Zhu, NL Tulloch, X Yang, NJ Sniadecki, MA Laflamme, WL Ruzzo, CE Murry, H Ruohola-Baker
Proceedings of the National Academy of Sciences 2015
Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity: Neural Stem Cells Oxidize Fatty Acids
EA Stoll, R Makin, IR Sweet, AJ Trevelyan, S Miwa, PJ Horner, DM Turnbull
Stem Cells 2015
Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation
RB Vega, JL Horton, DP Kelly
Circulation research 2015
Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs
L Jing, Y Hou, H Wu, Y Miao, X Li, J Cao, JM Brameld, T Parr, S Zhao
Scientific Reports 2015
Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype
AF Branco, SP Pereira, S Gonzalez, O Gusev, AA Rizvanov, PJ Oliveira, S Bellusci
PloS one 2015
αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium
MF Roggia, T Ueta, O Strauß
PloS one 2015
Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle
LD Tryon, MJ Crilly, DA Hood
American journal of physiology. Cell physiology 2015
Mitochondrial biogenesis and dynamics in the developing and diseased heart
Gerald W. Dorn II, Rick B. Vega, Daniel P. Kelly
Genes & development 2015
Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart
W Xu, T Barrientos, L Mao, HA Rockman, AA Sauve, NC Andrews
Cell Reports 2015
Nuclear respiratory factor 2 induces SIRT3 expression
FK Satterstrom, WR Swindell, G Laurent, S Vyas, ML Bulyk, MC Haigis
Aging Cell 2015
Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling
EM Richards, MB Rabaglino, A Antolic, CE Wood, M Keller-Wood
Physiological genomics 2015
Gaining Insights into Diabetic Cardiomyopathy from Drosophila
SB Diop, R Bodmer
Trends in Endocrinology & Metabolism 2015
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes
TP Patel, K Rawal, AK Bagchi, G Akolkar, N Bernardes, DS Dias, S Gupta, PK Singal
Heart Failure Reviews 2015
NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions
H Murata, H Takamatsu, S Liu, K Kataoka, N Huh, M Sakaguchi, Y Tsuji
PloS one 2015
Transcriptional Landscape of Cardiomyocyte Maturation
H Uosaki, P Cahan, DI Lee, S Wang, M Miyamoto, L Fernandez, DA Kass, C Kwon
Cell Reports 2015
Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice
G Gong, M Song, G Csordas, DP Kelly, SJ Matkovich, GW Dorn
Science 2015
BNIP3 is essential for mitochondrial bioenergetics during adipocyte remodelling in mice
JW Choi, A Jo, M Kim, HS Park, SS Chung, S Kang, KS Park
Diabetologia 2015
PGC-1α regulates the cell cycle through ATP and ROS in CH1 cells
X FU
Journal of Zhejiang University SCIENCE B 2015
A Proteomic Study of Memory After Imprinting in the Domestic Chick
M Meparishvili, M Nozadze, G Margvelani, BJ McCabe, RO Solomonia
Frontiers in behavioral neuroscience 2015
Muscle Transcriptional Profile Based on Muscle Fiber, Mitochondrial Respiratory Activity, and Metabolic Enzymes
X Liu, Y Du, N Trakooljul, B Brand, E Muráni, C Krischek, M Wicke, M Schwerin, K Wimmers, S Ponsuksili
International journal of biological sciences 2015
Dynamics of Fat Mass in DUhTP Mice Selected for Running Performance - Fat Mobilization in a Walk
J Brenmoehl, D Ohde, C Walz, J Schultz, A Tuchscherer, F Rieder, U Renne, A Hoeflich
Obesity facts 2015
β3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation
J Dong, J Zhao, M Zhang, G Liu, X Wang, Y Liu, N Yang, Y Liu, G Zhao, J Sun, J Tian, C Cheng, L Wei, Y Li, W Li
Journal of cardiovascular pharmacology and therapeutics 2015
Sirtuin 1: A Target for Kidney Diseases
Kong L, Wu H, Zhou W, Luo M, Tan Y, Miao L, Cai L
Molecular Medicine 2015
Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
Y Hasumi, M Baba, H Hasumi, Y Huang, M Lang, R Reindorf, HB Oh, S Sciarretta, K Nagashima, DC Haines, MD Schneider, RS Adelstein, LS Schmidt, J Sadoshima, WM Linehan
Human Molecular Genetics 2014
The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice
A Kohsaka, P Das, I Hashimoto, T Nakao, Y Deguchi, SS Gouraud, H Waki, Y Muragaki, M Maeda, NS Foulkes
PloS one 2014
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models: Boosting mitochondrial biogenesis as therapy
JC Komen, DR Thorburn
British Journal of Pharmacology 2014
Maternal cardiac metabolism in pregnancy
LX Liu, Z Arany
Cardiovascular Research 2014
PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy
J Choi, K Chandrasekaran, T Inoue, A Muragundla, JW Russell
Neurobiology of Disease 2014
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects: Caloric restriction and cardiac I/R injury
S Rohrbach, M Aslam, B Niemann, R Schulz
British Journal of Pharmacology 2014
Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis
TJ Kalogeris, C Baines, RJ Korthuis
PloS one 2014
Arginase inhibition ameliorates hepatic metabolic abnormalities in obese mice
J Moon, HJ Do, Y Cho, MJ Shin
PloS one 2014
Treadmill Training Increases SIRT-1 and PGC-1 α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner
NR Oliveira, SO Marques, TF Luciano, JR Pauli, LP Moura, E Caperuto, BL Pieri, J Engelmann, G Scaini, EL Streck, FS Lira, RA Pinho, ER Ropelle, AS Silva, CT de Souza
Mediators of Inflammation 2014
Syndecan-1 is required to maintain intradermal fat and prevent cold stress
I Kasza, Y Suh, D Wollny, RJ Clark, A Roopra, RJ Colman, OA MacDougald, TA Shedd, DW Nelson, MI Yen, CL Yen, CM Alexander
PLoS genetics 2014
Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models
C Marciniak, X Marechal, D Montaigne, R Neviere, S Lancel
Cardiovascular Diabetology 2014
The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans
G Gouspillou, N Sgarioto, B Norris, S Barbat-Artigas, M Aubertin-Leheudre, JA Morais, Y Burelle, T Taivassalo, RT Hepple
PloS one 2014
Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System
L Wang, L Di, CT Noguchi
International journal of biological sciences 2014
Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology
S Dasgupta, BW O'Malley
Journal of Molecular Endocrinology 2014
Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice
Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
2014
Exercise-induced PGC-1α transcriptional factors in skeletal muscle
S Jung, K Kim
2014
MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart
RA Gottlieb, A Stotland
2014
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization: PGC-1α and α-Syn in PD
J Eschbach, B Einem, K Müller, H Bayer, A Scheffold, BE Morrison, KL Rudolph, DR Thal, A Witting, P Weydt, M Otto, M Fauler, B Liss, PJ McLean, AR la Spada, AC Ludolph, JH Weishaupt, KM Danzer
2014
Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats
N Joffin, AM Jaubert, J Bamba, R Barouki, P Noirez, C Forest
2014
PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis
S Cui, O Tanabe, KC Lim, HE Xu, XE Zhou, JD Lin, L Shi, L Schmidt, A Campbell, R Shimizu, M Yamamoto, JD Engel
2014
Enhanced Cardiac Akt/PKB Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function Via Transcriptional Repression of Nuclear-Encoded Mitochondrial Genes
AR Wende, BT O'Neill, H Bugger, C Riehle, J Tuinei, J Buchanan, K Tsushima, L Wang, P Caro, A Guo, C Sloan, BJ Kim, X Wang, RO Pereira, MA McCrory, BG Nye, GA Benavides, VM Darley-Usmar, T Shioi, BC Weimer, ED Abel
2014
Promoting PGC-1 -driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts
G Karamanlidis, L Garcia-Menendez, SC Kolwicz, CF Lee, R Tian
American journal of physiology. Heart and circulatory physiology 2014
Effects of short-term endurance exercise training on acute doxorubicin-induced FoxO transcription in cardiac and skeletal muscle
AN Kavazis, AJ Smuder, SK Powers
Journal of applied physiology 2014
Metabolic Dysfunction Consistent With Premature Aging Results From Deletion of Pim Kinases
S Din, MH Konstandin, B Johnson, J Emathinger, M Volkers, H Toko, B Collins, L Ormachea, K Samse, DA Kubli, AD la Torre, AS Kraft, AB Gustafsson, DP Kelly, MA Sussman
Circulation research 2014
Maintaining PGC-1  expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function
RO Pereira, AR Wende, A Crum, D Hunter, CD Olsen, T Rawlings, C Riehle, WF Ward, ED Abel
The FASEB Journal 2014
Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity
KC Shekar, L Li, ER Dabkowski, W Xu, RF Ribeiro, PA Hecker, FA Recchia, RG Sadygov, B Willard, T Kasumov, WC Stanley
Journal of Molecular and Cellular Cardiology 2014
Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases.
Uittenbogaard M, Chiaramello A
Current pharmaceutical design 2014
PGC-1α expression is increased in leukocytes in experimental acute pancreatitis.
Llimona F, de Lima TM, Moretti AI, Theobaldo M, Jukemura J, Velasco IT, Machado MC, Souza HP
Inflammation 2014
Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice
K Drosatos, RS Khan, CM Trent, H Jiang, NH Son, WS Blaner, S Homma, PC Schulze, IJ Goldberg
Circulation. Heart failure 2013
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
R Haq, J Shoag, P Andreu-Perez, S Yokoyama, H Edelman, GC Rowe, DT Frederick, AD Hurley, A Nellore, AL Kung, JA Wargo, JS Song, DE Fisher, Z Arany, HR Widlund
Cancer Cell 2013
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
CJ Villanueva, L Vergnes, J Wang, BG Drew, C Hong, Y Tu, Y Hu, X Peng, F Xu, E Saez, K Wroblewski, AL Hevener, K Reue, LG Fong, SG Young, P Tontonoz
Cell Metabolism 2013
PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function
MJ Birket, S Casini, G Kosmidis, DA Elliott, AA Gerencser, A Baartscheer, C Schumacher, PG Mastroberardino, AG Elefanty, EG Stanley, CL Mummery
Stem Cell Reports 2013
Genetic models of PGC-1 and glucose metabolism and homeostasis
GC Rowe, Z Arany
Reviews in Endocrine and Metabolic Disorders 2013
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology
PS Eisele, C Handschin
Seminars in Immunopathology 2013
A mitochondrial basis for Huntington’s disease: therapeutic prospects
J Chakraborty, U Rajamma, KP Mohanakumar
Molecular and Cellular Biochemistry 2013
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription
P Gurha, T Wang, AH Larimore, Y Sassi, C Abreu-Goodger, MO Ramirez, AK Reddy, S Engelhardt, GE Taffet, XH Wehrens, ML Entman, A Rodriguez
PloS one 2013
WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury
KC O'Donnell, ME Vargas, A Sagasti
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats
H Rehman, Y Krishnasamy, K Haque, RG Thurman, JJ Lemasters, RG Schnellmann, Z Zhong
PloS one 2013
Potential mechanisms of exercise in gestational diabetes
S Golbidi, I Laher
Journal of nutrition and metabolism 2013
Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study
Z Lian, W Chai, LL Shi, C Chen, J Liu, Y Wang
PloS one 2013
Delineation of the key aspects in the regulation of epithelial monolayer formation
L Aschauer, LN Gruber, W Pfaller, A Limonciel, TJ Athersuch, R Cavill, A Khan, G Gstraunthaler, J Grillari, R Grillari, P Hewitt, MO Leonard, A Wilmes, P Jennings
Molecular and cellular biology 2013
Opa1 is required for proper mitochondrial metabolism in early development
JJ Rahn, KD Stackley, SS Chan
PloS one 2013
PGC1α plays a critical role in TWEAK-induced cardiac dysfunction
J Shi, B Jiang, Y Qiu, J Guan, M Jain, X Cao, M Bauer, L Su, LC Burkly, TC Leone, DP Kelly, R Liao
PloS one 2013
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes
SC Kolwicz, S Purohit, R Tian
Circulation research 2013
Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells
Y Cho, BC Hazen, AP Russell, A Kralli
The Journal of biological chemistry 2013
Cardiomyocyte autophagy: metabolic profit and loss
ZV Wang, A Ferdous, JA Hill
Heart Failure Reviews 2013
Mitochondrial dysfunction in heart failure
MG Rosca, CL Hoppel
Heart Failure Reviews 2013
Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila
Srividya Chandramouli Iyer, Eswar P Ramachandran Iyer, Ramakrishna Meduri, Myurajan Rubaharan, Aravinda Kuntimaddi, Madhu Karamsetty, Daniel N Cox
2013
Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart
CC Hughey, FD James, L Ma, DP Bracy, Z Wang, DH Wasserman, JN Rottman, J Shearer
American journal of physiology. Cell physiology 2013
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1
DG Corum, PN Tsichlis, RC Muise-Helmericks
The FASEB Journal 2013
A Role for Peroxisome Proliferator-activated Receptor   Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis
L Lai, M Wang, OJ Martin, TC Leone, RB Vega, X Han, DP Kelly
The Journal of biological chemistry 2013
Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
W Liu, BH Beck, KS Vaidya, KT Nash, KP Feeley, SW Ballinger, KM Pounds, WL Denning, AR Diers, A Landar, A Dhar, T Iwakuma, DR Welch
Cancer research 2013
A Role for Peroxisome Proliferator-Activated Receptor   Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth
OJ Martin, L Lai, MM Soundarapandian, TC Leone, A Zorzano, MP Keller, AD Attie, DM Muoio, DP Kelly
Circulation research 2013
Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension
J Gomez-Arroyo, S Mizuno, K Szczepanek, BV Tassell, R Natarajan, CG dos Remedios, JI Drake, L Farkas, D Kraskauskas, DS Wijesinghe, CE Chalfant, J Bigbee, A Abbate, EJ Lesnefsky, HJ Bogaard, NF Voelkel
Circulation. Heart failure 2013
Mitochondrial biogenesis and dynamics in neurodegeneration: a causative relationship.
Nikoletopoulou V, Tavernarakis N
Neurochemical Research 2013
The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing.
Luu L, Dai FF, Prentice KJ, Huang X, Hardy AB, Hansen JB, Liu Y, Joseph JW, Wheeler MB
Diabetologia 2013
Protective effects of garlic extract on cardiac function, heart rate variability, and cardiac mitochondria in obese insulin-resistant rats.
Supakul L, Pintana H, Apaijai N, Chattipakorn S, Shinlapawittayatorn K, Chattipakorn N
European Journal of Nutrition 2013
Mitochondrial Oxidative Phosphorylation
B Kadenbach
Mitochondrial Oxidative Phosphorylation 2012
Exercise in the Metabolic Syndrome
S Golbidi, A Mesdaghinia, I Laher
Oxidative medicine and cellular longevity 2012
Role of Mitochondrial Homeostasis and Dynamics in Alzheimer's Disease
JE Selfridge, L E, J Lu, RH Swerdlow
Neurobiology of Disease 2012
Integrin-Dependent Akt1 Activation Regulates PGC-1 Expression and Fatty Acid Oxidation
CC Beeson, GC Beeson, H Buff, J Eldridge, A Zhang, A Seth, M Demcheva, JN Vournakis, RC Muise-Helmericks
Journal of Vascular Research 2012
The role of PGC-1 coactivators in aging skeletal muscle and heart
LM Dillon, AP Rebelo, CT Moraes
IUBMB Life 2012
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse
LM Dillon, SL Williams, A Hida, JD Peacock, TA Prolla, J Lincoln, CT Moraes
Human Molecular Genetics 2012
Shaping the role of mitochondria in the pathogenesis of Huntington's disease
V Costa, L Scorrano
The EMBO Journal 2012
Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction
SB Diop, R Bodmer
Journal of Cellular and Molecular Medicine 2012
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
IS Patten, S Rana, S Shahul, GC Rowe, C Jang, L Liu, MR Hacker, JS Rhee, J Mitchell, F Mahmood, P Hess, C Farrell, N Koulisis, EV Khankin, SD Burke, I Tudorache, J Bauersachs, F Monte, D Hilfiker-Kleiner, SA Karumanchi, Z Arany
Nature 2012
Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
C Ciron, S Lengacher, J Dusonchet, P Aebischer, BL Schneider
Human Molecular Genetics 2012
Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome
AR Aroor, C Mandavia, J Ren, JR Sowers, L Pulakat
Cardiorenal Medicine 2012
Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells
N Nikolić, M Rhedin, AC Rustan, L Storlien, GH Thoresen, M Strömstedt
Biochemistry Research International 2012
Carbon Monoxide Improves Cardiac Function and Mitochondrial Population Quality in a Mouse Model of Metabolic Syndrome
S Lancel, D Montaigne, X Marechal, C Marciniak, SM Hassoun, B Decoster, C Ballot, C Blazejewski, D Corseaux, B Lescure, R Motterlini, R Neviere
PloS one 2012
Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions
AM Joseph, DR Joanisse, RG Baillot, DA Hood
Experimental Diabetes Research 2012
Reactive Oxygen Species-Mediated Control of Mitochondrial Biogenesis
ED Yoboue, A Devin
International Journal of Cell Biology 2012
Rescue of Dystrophic Skeletal Muscle by PGC-1α Involves a Fast to Slow Fiber Type Shift in the mdx Mouse
JT Selsby, KJ Morine, K Pendrak, ER Barton, HL Sweeney
PloS one 2012
Transcriptional integration of mitochondrial biogenesis
RC Scarpulla, RB Vega, DP Kelly
Trends in Endocrinology & Metabolism 2012
PGC-1 Proteins and Heart Failure
C Riehle, ED Abel
Trends in Cardiovascular Medicine 2012
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart
G Aubert, RB Vega, DP Kelly
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012
Mitochondria in cardiac hypertrophy and heart failure
MG Rosca, B Tandler, CL Hoppel
Journal of Molecular and Cellular Cardiology 2012
Mitochondrial network in the heart
Q Li, LY Zhou, GF Gao, JQ Jiao, PF Li
Protein & Cell 2012
Mitochondria as a Therapeutic Target in Heart Failure
M Bayeva, M Gheorghiade, H Ardehali
Journal of the American College of Cardiology 2012
IL-6 is not necessary for the regulation of adipose tissue mitochondrial content
Z Wan, CG Perry, T Macdonald, CB Chan, GP Holloway, DC Wright
PloS one 2012
SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α
R Cai, T Yu, C Huang, X Xia, X Liu, J Gu, S Xue, ET Yeh, J Cheng
The Journal of biological chemistry 2012
Mitochondria and mitophagy: the yin and yang of cell death control
DA Kubli, ÅB Gustafsson
Circulation research 2012
Role of PGC-1α signaling in skeletal muscle health and disease
C Kang, LL Ji
Annals of the New York Academy of Sciences 2012
NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis
JS Chang, V Fernand, Y Zhang, J Shin, HJ Jun, Y Joshi, TW Gettys
The Journal of biological chemistry 2012
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
A Cheng, R Wan, JL Yang, N Kamimura, TG Son, X Ouyang, Y Luo, E Okun, MP Mattson
Nature Communications 2012
Peroxisome Proliferator-Activated Receptors (PPARs)
MZ Badr, JA Youssef
Peroxisome Proliferator-Activated Receptors (PPARs) 2012
Defects of mtDNA Replication Impaired Mitochondrial Biogenesis During Trypanosoma cruzi Infection in Human Cardiomyocytes and Chagasic Patients: The Role of Nrf1/2 and Antioxidant Response
X Wan, S Gupta, MP Zago, MM Davidson, P Dousset, A Amoroso, NJ Garg
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2012
Telomeres and Mitochondria in the Aging Heart
J Moslehi, RA DePinho, E Sahin, D Sinclair, B North
Circulation research 2012
Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart
KN Papanicolaou, R Kikuchi, GA Ngoh, KA Coughlan, I Dominguez, WC Stanley, K Walsh
Circulation research 2012
PGC-1α: a master gene that is hard to master.
Lindholm D, Eriksson O, Mäkelä J, Belluardo N, Korhonen L
Cellular and molecular life sciences : CMLS 2012
Role of neuropeptide Y and peroxisome proliferator-activated receptor γ coactivator-1α in stress cardiomyopathy.
Ananda S, Wang Y, Zhu S, Wang R, Zhou X, Zhuo L, Sun T, Ren L, Liu Q, Dong H, Liu Y, Liu L
2012
PGC-1 coactivators in the control of energy metabolism
C Liu, JD Lin
Acta Biochimica et Biophysica Sinica 2011
Peroxisome Proliferator Activated Receptor-Alpha (PPARα) and PPAR Gamma Coactivator-1alpha (PGC-1α) Regulation of Cardiac Metabolism in Diabetes
JG Duncan
Pediatric Cardiology 2011
Differential expression of PGC-1α and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts
JL García-Giménez, A Gimeno, P Gonzalez-Cabo, F Dasí, A Bolinches-Amorós, B Mollá, F Palau, FV Pallardó
PloS one 2011
Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes
Y Nakamura, E Hinoi, T Takarada, Y Takahata, T Yamamoto, H Fujita, S Takada, S Hashizume, Y Yoneda
PloS one 2011
G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart
J Pang, X Xu, MR Getman, X Shi, SL Belmonte, H Michaloski, A Mohan, BC Blaxall, BC Berk
Journal of Molecular and Cellular Cardiology 2011
FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
MJ Potthoff, J Boney-Montoya, M Choi, T He, NE Sunny, S Satapati, K Suino-Powell, HE Xu, RD Gerard, BN Finck, SC Burgess, DJ Mangelsdorf, SA Kliewer
Cell Metabolism 2011
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
G Haemmerle, T Moustafa, G Woelkart, S Büttner, A Schmidt, T de Weijer, M Hesselink, D Jaeger, PC Kienesberger, K Zierler, R Schreiber, T Eichmann, D Kolb, P Kotzbeck, M Schweiger, M Kumari, S Eder, G Schoiswohl, N Wongsiriroj, NM Pollak, FP Radner, K Preiss-Landl, T Kolbe, T Rülicke, B Pieske, M Trauner, A Lass, R Zimmermann, G Hoefler, S Cinti, EE Kershaw, P Schrauwen, F Madeo, B Mayer, R Zechner
Nature Medicine 2011
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
R Mitra, DP Nogee, JF Zechner, K Yea, CM Gierasch, A Kovacs, DM Medeiros, DP Kelly, JG Duncan
Journal of Molecular and Cellular Cardiology 2011
Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress
RC Scarpulla
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2011
Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis*
A Safdar, JP Little, AJ Stokl, BP Hettinga, M Akhtar, MA Tarnopolsky
The Journal of biological chemistry 2011
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate
I D'Errico, L Salvatore, S Murzilli, GL Sasso, D Latorre, N Martelli, AV Egorova, R Polishuck, K Madeyski-Bengtson, C Lelliott, AJ Vidal-Puig, P Seibel, G Villani, A Moschetta
Proceedings of the National Academy of Sciences 2011
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
P Krebs, W Fan, YH Chen, K Tobita, MR Downes, MR Wood, L Sun, X Li, Y Xia, N Ding, JM Spaeth, EM Moresco, TG Boyer, CW Lo, J Yen, RM Evans, B Beutler
Proceedings of the National Academy of Sciences 2011
Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling
JE Rame, LA Barouch, MN Sack, EG Lynn, M Abu-Asab, M Tsokos, SJ Kern, JJ Barb, PJ Munson, MK Halushka, KL Miller, K Fox-Talbot, J Zhang, JM Hare, MA Solomon, RL Danner
Physiological genomics 2011
Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway
J Murray, JM Huss
AJP Cell Physiology 2011
Does calorie restriction induce mitochondrial biogenesis? A reevaluation
CR Hancock, DH Han, K Higashida, SH Kim, JO Holloszy
The FASEB Journal 2011
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy
RL Fogle, CS Hollenbeak, BA Stanley, TC Vary, SR Kimball, CJ Lynch
Physiological genomics 2011
A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression
AA Grimm, CS Brace, T Wang, GD Stormo, S Imai
Aging Cell 2011
Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
MA Kiebish, DM Young, JJ Lehman, X Han
Journal of lipid research 2011
Transcriptional control of cardiac fuel metabolism and mitochondrial function
TC Leone, DP Kelly
Cold Spring Harbor Symposia on Quantitative Biology 2011
The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation
KM Wadosky, MS Willis
American journal of physiology. Heart and circulatory physiology 2011
Scaling factors: transcription factors regulating subcellular domains
JC Mills, PH Taghert
BioEssays : news and reviews in molecular, cellular and developmental biology 2011
Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism
CC Hughey, VL Johnsen, L Ma, FD James, PP Young, DH Wasserman, JN Rottman, DS Hittel, J Shearer
American journal of physiology. Endocrinology and metabolism 2011
Telomeres and mitochondrial function
T Finkel
Circulation research 2011
Peroxisome Proliferator-Activated Receptor β/δ Activation in Adult Hearts Facilitates Mitochondrial Function and Cardiac Performance Under Pressure-Overload Condition
J Liu, P Wang, J Luo, Y Huang, L He, H Yang, Q Li, S Wu, O Zhelyabovska, Q Yang
Hypertension 2011
IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1α
FB Hickey, JB Corcoran, NG Docherty, B Griffin, U Bhreathnach, F Furlong, F Martin, C Godson, M Murphy
Journal of the American Society of Nephrology : JASN 2011
The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.
Bonda DJ, Smith MA, Perry G, Lee HG, Wang X, Zhu X
Current pharmaceutical design 2011
Role of NYGGF4 in insulin resistance.
Chen X, Huang Z, Chen D, Jia G, Mao X, Wu X
Molecular Biology Reports 2011
Transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress
Preeti Ahuja, Peng Zhao, Ekaterini Angelis, Hongmei Ruan, Paavo Korge, Aaron Olson, Yibin Wang, Eunsook Jin, Mark Jeffrey, Michael Portman, Robb MacLellan
Journal of Clinical Investigation 2010
Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function
A Fritah, JH Steel, D Nichol, N Parker, S Williams, A Price, L Strauss, TA Ryder, MA Mobberley, M Poutanen, M Parker, R White
Cardiovascular Research 2010
Diabetic cardiomyopathy: signaling defects and therapeutic approaches
JS Dobrin, D Lebeche
Expert Review of Cardiovascular Therapy 2010
Mitochondrial Pruning by Nix and BNip3: An Essential Function for Cardiac-Expressed Death Factors
GW 2nd
Journal of Cardiovascular Translational Research 2010
Mitochondria in the diabetic heart
H Bugger, ED Abel
Cardiovascular Research 2010
Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?
B Su, X Wang, D Bonda, G Perry, M Smith, X Zhu
Molecular Neurobiology 2010
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity
VA Lira, CR Benton, Z Yan, A Bonen
American journal of physiology. Endocrinology and metabolism 2010
A conserved role for syndecan family members in the regulation of whole-body energy metabolism
MD Luca, YC Klimentidis, K Casazza, MM Chambers, R Cho, ST Harbison, P Jumbo-Lucioni, S Zhang, J Leips, JR Fernandez
PloS one 2010
Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury
B Jian, S Yang, D Chen, L Zou, JC Chatham, I Chaudry, R Raju
Molecular Medicine 2010
Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans
VJ Exil, DS Avila, A Benedetto, EA Exil, MR Adams, C Au, M Aschner
PloS one 2010
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
J Burchard, C Zhang, AM Liu, RT Poon, NP Lee, KF Wong, PC Sham, BY Lam, MD Ferguson, G Tokiwa, R Smith, B Leeson, R Beard, JR Lamb, L Lim, M Mao, H Dai, JM Luk
Molecular Systems Biology 2010
Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction
S Koene, J Smeitink
Journal of Inherited Metabolic Disease 2010
Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
RK Chaturvedi, NY Calingasan, L Yang, T Hennessey, A Johri, MF Beal
Human Molecular Genetics 2010
Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1
JS Chang, P Huypens, Y Zhang, C Black, A Kralli, TW Gettys
The Journal of biological chemistry 2010
Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein
AS Ebrahim, LW Ko, SH Yen
Neuroscience Letters 2010
Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM
Y Hamanaka, D Park, P Yin, SP Annangudi, TN Edwards, J Sweedler, IA Meinertzhagen, PH Taghert
Current biology : CB 2010
Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
C Zechner, L Lai, JF Zechner, T Geng, Z Yan, JW Rumsey, D Collia, Z Chen, DF Wozniak, TC Leone, DP Kelly
Cell Metabolism 2010
Mitochondria in heart failure
MG Rosca, CL Hoppel
Cardiovascular Research 2010
Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats
CR Benton, GP Holloway, XX Han, Y Yoshida, LA Snook, J Lally, JF Glatz, JJ Luiken, A Chabowski, A Bonen
Diabetologia 2010
Cardiac function and disease: emerging role of SUMO conjugation
J Wang
Wiley interdisciplinary reviews. Systems biology and medicine 2010
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
RC Scarpulla
Biochimica et Biophysica Acta 2010
Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway*
J Trausch-Azar, TC Leone, DP Kelly, AL Schwartz
The Journal of biological chemistry 2010
Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1
EG Lynn, MV Stevens, RP Wong, D Carabenciov, J Jacobson, E Murphy, MN Sack
Journal of Molecular and Cellular Cardiology 2010
The PGC-1 cascade as a therapeutic target for heart failure
J Schilling, DP Kelly
Journal of Molecular and Cellular Cardiology 2010
Tracing cardiac metabolism in vivo: one substrate at a time
H Taegtmeyer
Journal of Nuclear Medicine 2010
Return to the fetal gene program: a suggested metabolic link to gene expression in the heart
H Taegtmeyer, S Sen, D Vela
Annals of the New York Academy of Sciences 2010
Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals
LA Consitt, JA Bell, TR Koves, DM Muoio, MW Hulver, KR Haynie, GL Dohm, JA Houmard
2010
Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function
JM Juang, L las Fuentes, AD Waggoner, CC Gu, VG Dávila-Román
BMC Medical Genetics 2010
PGC-1 Coactivators in Cardiac Development and Disease
GC Rowe, A Jiang, Z Arany, DP Kelly
Circulation research 2010
Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts
G Karamanlidis, L Nascimben, GS Couper, PS Shekar, F del Monte, R Tian
Circulation research 2010
Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators
JG Duncan, KG Bharadwaj, JL Fong, R Mitra, N Sambandam, MR Courtois, KJ Lavine, IJ Goldberg, DP Kelly
Circulation 2010
Statins enhance peroxisome proliferator-activated receptor gamma coactivator-1alpha activity to regulate energy metabolism.
Wang W, Wong CW
Journal of Molecular Medicine 2010
Mitochondrial Fe-S cluster biogenesis, frataxin and the modulation of susceptibility to drug-induced cardiomyopathy.
Sack MN
Aging 2010
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
G Coppola, D Marmolino, D Lu, Q Wang, M Cnop, M Rai, F Acquaviva, S Cocozza, M Pandolfo, DH Geschwind
Human Molecular Genetics 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
LW Finley, MC Haigis
Ageing Research Reviews 2009
Metabolic Therapy at the Crossroad: How to Optimize Myocardial Substrate Utilization?
SC Kolwicz, R Tian
Trends in Cardiovascular Medicine 2009
Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice
D Sanoudou, A Duka, K Drosatos, KC Hayes, VI Zannis
The Pharmacogenomics Journal 2009
PGC-1alpha in aging and anti-aging interventions
R Anderson, T Prolla
Biochimica et Biophysica Acta 2009
MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice
AH Pereira, CF Clemente, AC Cardoso, TH Theizen, SA Rocco, CC Judice, MC Guido, VD Pascoal, I Lopes-Cendes, JR Souza, KG Franchini
PloS one 2009
Type 2 diabetes, mitochondrial biology and the heart
MN Sack
Journal of Molecular and Cellular Cardiology 2009
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity
H Liang, B Balas, P Tantiwong, J Dube, BH Goodpaster, RM O'Doherty, RA DeFronzo, A Richardson, N Musi, WF Ward
American journal of physiology. Endocrinology and metabolism 2009
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure
H Lee, Q Chen, JA Wolfram, SL Richardson, A Liner, SL Siedlak, X Zhu, NP Ziats, H Fujioka, DW Felsher, RJ Castellani, ML Valencik, JA McDonald, BD Hoit, EJ Lesnefsky, MA Smith
PloS one 2009
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice
PJ Schaeffer, J Desantiago, J Yang, TP Flagg, A Kovacs, CJ Weinheimer, M Courtois, TC Leone, CG Nichols, DM Bers, DP Kelly
American journal of physiology. Heart and circulatory physiology 2009
High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
Y Li, L Cheng, Q Qin, J Liu, W Lo, LA Brako, Q Yang
Journal of Molecular and Cellular Cardiology 2009
Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart
Y Li, R Yin, J Liu, P Wang, S Wu, J Luo, O Zhelyabovska, Q Yang
Journal of Molecular and Cellular Cardiology 2009
Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia
JL Gamboa, FH Andrade
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha
Y Zhang, P Huypens, AW Adamson, JS Chang, TM Henagan, A Boudreau, NR Lenard, D Burk, J Klein, N Perwitz, J Shin, M Fasshauer, A Kralli, TW Gettys
The Journal of biological chemistry 2009
The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation
KK Baxter, M Uittenbogaard, J Yoon, A Chiaramello
ASN NEURO 2009
Mitochondria and energetic depression in cell pathophysiology
E Seppet, M Gruno, A Peetsalu, Z Gizatullina, HP Nguyen, S Vielhaber, MH Wussling, S Trumbeckaite, O Arandarcikaite, D Jerzembeck, M Sonnabend, K Jegorov, S Zierz, F Striggow, FN Gellerich
International journal of molecular sciences 2009
PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders
S Srivastava, F Diaz, L Iommarini, K Aure, A Lombes, CT Moraes
Human Molecular Genetics 2009
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
KA O'Hagan, S Cocchiglia, AV Zhdanov, MM Tambuwala, MM Tambawala, EP Cummins, M Monfared, TA Agbor, JF Garvey, DB Papkovsky, CT Taylor, BB Allan
Proceedings of the National Academy of Sciences 2009
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha
S Li, E Arning, C Liu, V Vitvitsky, C Hernandez, R Banerjee, T Bottiglieri, JD Lin
American journal of physiology. Endocrinology and metabolism 2009
Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells
RM Cowell, P Talati, KR Blake, JH Meador-Woodruff, JW Russell
Biochemical and Biophysical Research Communications 2009
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart
S Sihag, S Cresci, AY Li, CC Sucharov, JJ Lehman
Journal of Molecular and Cellular Cardiology 2009
Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria
K Vercauteren, N Gleyzer, RC Scarpulla
The Journal of biological chemistry 2009
Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy
M Luedde, U Flögel, M Knorr, C Grundt, HJ Hippe, B Brors, D Frank, U Haselmann, C Antony, M Voelkers, J Schrader, P Most, B Lemmer, HA Katus, N Frey
Journal of Molecular Medicine 2009
Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio)
CM LeMoine, PM Craig, K Dhekney, JJ Kim, GB McClelland
Journal of Comparative Physiology B 2009
Number matters: control of mammalian mitochondrial DNA copy number
LL Montier, JJ Deng, Y Bai
Journal of Genetics and Genomics 2009
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
C Cantó, J Auwerx
Current Opinion in Lipidology 2009
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
S Gundewar, JW Calvert, S Jha, I Toedt-Pingel, SY Ji, D Nunez, A Ramachandran, M Anaya-Cisneros, R Tian, DJ Lefer
Circulation research 2009
Minireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism
JD Lin
Molecular Endocrinology 2009
Mitochondria and Reactive Oxygen Species
F Addabbo, M Montagnani, MS Goligorsky
Hypertension 2009
Bcl3 Interacts Cooperatively with Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Coactivator 1α To Coactivate Nuclear Receptors Estrogen-Related Receptor α and PPARα
J Yang, RS Williams, DP Kelly
Molecular and cellular biology 2009
5-Hydroxytryptamine Receptor Stimulation of Mitochondrial Biogenesis
KA Rasbach, JA Funk, T Jayavelu, PT Green, RG Schnellmann
The Journal of pharmacology and experimental therapeutics 2009
Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload
X Hu, X Xu, Y Huang, J Fassett, TP Flagg, Y Zhang, CG Nichols, RJ Bache, Y Chen
Circulation research 2008
Hexarelin Signaling to PPARγ in Metabolic Diseases
A Demers, A Rodrigue-Way, A Tremblay
PPAR Research 2008
Nuclear receptors, mitochondria and lipid metabolism
WA Alaynick
Mitochondrion 2008
Cardiac PPARα Protein Expression is Constant as Alternate Nuclear Receptors and PGC-1 Coordinately Increase During the Postnatal Metabolic Transition
NE Buroker, XH Ning, M Portman
PPAR Research 2008
Energy metabolism in heart failure and remodelling
JS Ingwall
Cardiovascular Research 2008
Targeting the mitochondria to augment myocardial protection
DR Schwartz, MN Sack
Current Opinion in Pharmacology 2008
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart
L Lai, TC Leone, C Zechner, PJ Schaeffer, SM Kelly, DP Flanagan, DM Medeiros, A Kovacs, DP Kelly
Genes & development 2008
Sex-specific pathways in early cardiac response to pressure overload in mice
H Witt, C Schubert, J Jaekel, D Fliegner, A Penkalla, K Tiemann, J Stypmann, S Roepcke, S Brokat, S Mahmoodzadeh, E Brozova, MM Davidson, PR Noppinger, C Grohé, V Regitz-Zagrosek
Journal of Molecular Medicine 2008
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
JJ Lehman, S Boudina, NH Banke, N Sambandam, X Han, DM Young, TC Leone, RW Gross, ED Lewandowski, ED Abel, DP Kelly
American journal of physiology. Heart and circulatory physiology 2008
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase
GL Wright, IG Maroulakou, J Eldridge, TL Liby, V Sridharan, PN Tsichlis, RC Muise-Helmericks
The FASEB Journal 2008
Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism
S Li, C Liu, N Li, T Hao, T Han, DE Hill, M Vidal, JD Lin
Cell Metabolism 2008
Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes
EA Konorev, S Vanamala, B Kalyanaraman
Free radical biology & medicine 2008
Mitochondrial fragmentation in neurodegeneration
AB Knott, G Perkins, R Schwarzenbacher, E Bossy-Wetzel
Nature reviews. Neuroscience 2008
Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation
RM Cowell, KR Blake, T Inoue, JW Russell
Neuroscience Letters 2008
Maternal undernutrition induces differential cardiac gene expression in pulmonary hypertensive steers at high elevation
H Han, TR Hansen, B Berg, BW Hess, SP Ford
American journal of physiology. Heart and circulatory physiology 2008
Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids
JB Lockridge, ML Sailors, DJ Durgan, O Egbejimi, WJ Jeong, MS Bray, WC Stanley, ME Young
Journal of lipid research 2008
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster
J Chen, X Shi, R Padmanabhan, Q Wang, Z Wu, SC Stevenson, M Hild, D Garza, H Li
Genome research 2008
Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis
MS Carraway, HB Suliman, C Kliment, KE Welty-Wolf, TD Oury, CA Piantadosi
Antioxidants & Redox Signaling 2008
PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure
NF Mistry, S Cresci
Heart Failure Reviews 2008
Metabolic Reserve of the Heart: The Forgotten Link Between Contraction and Coronary Flow
C Kassiotis, M Rajabi, H Taegtmeyer
Progress in Cardiovascular Diseases 2008
Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism
DR Gutsaeva, MS Carraway, HB Suliman, IT Demchenko, H Shitara, H Yonekawa, CA Piantadosi
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
The PPARGC1AGly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
E Ingelsson, L Bennet, M Ridderstråle, M Söderström, L Råstam, U Lindblad
BMC Cardiovascular Disorders 2008
Role of Mitochondrial Dysfunction in Insulin Resistance
J Kim, Y Wei, JR Sowers
Circulation research 2008
Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart
CC Preston, AS Oberlin, EL Holmuhamedov, A Gupta, S Sagar, RH Syed, SA Siddiqui, S Raghavakaimal, A Terzic, A Jahangir
Mechanisms of Ageing and Development 2008
Adaptation and Maladaptation of the Heart in Obesity
R Harmancey, CR Wilson, H Taegtmeyer
Hypertension 2008
Beneficial Effects of Exercise on Muscle Mitochondrial Function in Diabetes Mellitus:
JA Lumini, J Magalhães, PJ Oliveira, A Ascensão
Sports Medicine 2008
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
BT O'Neill, J Kim, AR Wende, HA Theobald, J Tuinei, J Buchanan, A Guo, VG Zaha, DK Davis, JC Schell, S Boudina, B Wayment, SE Litwin, T Shioi, S Izumo, MJ Birnbaum, ED Abel
Cell Metabolism 2007
The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium
JG Duncan, BN Finck
PPAR Research 2007
Oxidative stress and transcriptional regulation in Alzheimer disease
Q Shi, GE Gibson
Alzheimer Disease and Associated Disorders 2007
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
T Trian, G Benard, H Begueret, R Rossignol, PO Girodet, D Ghosh, O Ousova, JM Vernejoux, R Marthan, JM Tunon-de-Lara, P Berger
Journal of Experimental Medicine 2007
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways
JT Rodgers, C Lerin, Z Gerhart-Hines, P Puigserver
FEBS Letters 2007
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
NL Spector, Y Yarden, B Smith, L Lyass, P Trusk, K Pry, JE Hill, W Xia, R Seger, SS Bacus
Proceedings of the National Academy of Sciences 2007
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha
LM Rohas, J St-Pierre, M Uldry, S Jäger, C Handschin, BM Spiegelman
Proceedings of the National Academy of Sciences 2007
PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations
S Srivastava, JN Barrett, CT Moraes
Human Molecular Genetics 2007
Return to the fetal gene program protects the stressed heart: a strong hypothesis
M Rajabi, C Kassiotis, P Razeghi, H Taegtmeyer
Heart Failure Reviews 2007
Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor- /PGC-1  Gene Regulatory Pathway
JG Duncan, JL Fong, DM Medeiros, BN Finck, DP Kelly
Circulation 2007
Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse
P Hakimi, J Yang, G Casadesus, D Massillon, F Tolentino-Silva, CK Nye, ME Cabrera, DR Hagen, CB Utter, Y Baghdy, DH Johnson, DL Wilson, JP Kirwan, SC Kalhan, RW Hanson
The Journal of biological chemistry 2007
Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart
H de Jong, AC Neal, RA Coleman, TM Lewin
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2007
Mitochondria are impaired in the adipocytes of type 2 diabetic mice
HJ Choo, JH Kim, OB Kwon, CS Lee, JY Mun, SS Han, YS Yoon, G Yoon, KM Choi, YG Ko
Diabetologia 2006
Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP
S Miura, E Tomitsuka, Y Kamei, T Yamazaki, Y Kai, M Tamura, K Kita, I Nishino, O Ezaki
The American Journal of Pathology 2006
The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor
X Ding, K Lichti, JL Staudinger
Toxicological sciences : an official journal of the Society of Toxicology 2006
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha
Z Arany, M Novikov, S Chin, Y Ma, A Rosenzweig, BM Spiegelman
Proceedings of the National Academy of Sciences 2006
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
CR Vianna, M Huntgeburth, R Coppari, CS Choi, J Lin, S Krauss, G Barbatelli, I Tzameli, YB Kim, S Cinti, GI Shulman, BM Spiegelman, BB Lowell
Cell Metabolism 2006
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance
CJ Lelliott, G Medina-Gomez, N Petrovic, A Kis, HM Feldmann, M Bjursell, N Parker, K Curtis, M Campbell, P Hu, D Zhang, SE Litwin, VG Zaha, KT Fountain, S Boudina, M Jimenez-Linan, M Blount, M Lopez, A Meirhaeghe, M Bohlooly-Y, L Storlien, M Strömstedt, M Snaith, M Oresic, ED Abel, B Cannon, A Vidal-Puig
PLoS Biology 2006
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model
S Giri, R Rattan, E Haq, M Khan, R Yasmin, J Won, L Key, AK Singh, I Singh
Nutrition & Metabolism 2006
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
BN Finck, DP Kelly
Journal of Clinical Investigation 2006
On the hypothesis that the failing heart is energy starved: Lessons learned from the metabolism of ATP and creatine
JS Ingwall
Current Hypertension Reports 2006
Deranged energy substrate metabolism in the failing heart
Q Tian, PM Barger
Current Hypertension Reports 2006
The metabolic syndrome and the heart—: a considered opinion
JG Leichman, VR Lavis, D Aguilar, CR Wilson, H Taegtmeyer
Clinical Research in Cardiology 2006
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB
Cell Metabolism 2006
Burn injury causes mitochondrial dysfunction in skeletal muscle
KE Padfield, LG Astrakas, Q Zhang, S Gopalan, G Dai, MN Mindrinos, RG Tompkins, LG Rahme, AA Tzika
Proceedings of the National Academy of Sciences 2005
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
AR Wende, JM Huss, PJ Schaeffer, V Giguère, DP Kelly
Molecular and cellular biology 2005
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
DC Wallace
Annual Review of Genetics 2005
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity
G Andersen, L Wegner, K Yanagisawa, CS Rose, J Lin, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, BM Spiegelman, O Pedersen
Journal of medical genetics 2005
Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training
J Zoll, R Steiner, K Meyer, M Vogt, H Hoppeler, M Flück
European Journal of Applied Physiology 2005
Mitochondrial energy metabolism in heart failure: a question of balance
JM Huss, DP Kelly
Journal of Clinical Investigation 2005
Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators
N Gleyzer, K Vercauteren, RC Scarpulla
Molecular and cellular biology 2005
Cloning and expression of PPAR-gamma and PGC-1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus.
Eddy SF, Morin P Jr, Storey KB
Molecular and Cellular Biochemistry 2005
Mitochondrial energy metabolism in heart failure: a question of balance.
Huss JM, Kelly DP
Journal of Clinical Investigation 2005
c-Cbl deficient mice have reduced adiposity, higher energy expenditure and improved peripheral insulin action
Juan C. Molero, Thomas Jensen, Phil C. Withers, Michelle Couzens, Herbert Herzog, Christine B.F. Thien, Wallace Y. Langdon, Ken Walder, Maria A. Murphy, David D.L. Bowtell, David E. James, and Gregory J. Cooney
Journal of Clinical Investigation 2004
Rapid transformation of white adipocytes into fat-oxidizing machines
L Orci, WS Cook, M Ravazzola, MY Wang, BH Park, R Montesano, RH Unger
Proceedings of the National Academy of Sciences 2004
Regulation of muscle fiber type and running endurance by PPARdelta
YX Wang, CL Zhang, RT Yu, HK Cho, MC Nelson, CR Bayuga-Ocampo, J Ham, H Kang, RM Evans
PLoS Biology 2004
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
E Nisoli, S Falcone, C Tonello, V Cozzi, L Palomba, M Fiorani, A Pisconti, S Brunelli, A Cardile, M Francolini, O Cantoni, MO Carruba, S Moncada, E Clementi
Proceedings of the National Academy of Sciences 2004
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
Y Zhang, LW Castellani, CJ Sinal, FJ Gonzalez, PA Edwards
Genes & development 2004
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure
M Sano, SC Wang, M Shirai, F Scaglia, M Xie, S Sakai, T Tanaka, PA Kulkarni, PM Barger, KA Youker, GE Taffet, Y Hamamori, LH Michael, WJ Craigen, MD Schneider
The EMBO Journal 2004
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
SN Schreiber, R Emter, MB Hock, D Knutti, J Cardenas, M Podvinec, EJ Oakeley, A Kralli
Proceedings of the National Academy of Sciences 2004
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
M Fan, J Rhee, J St-Pierre, C Handschin, P Puigserver, J Lin, S Jäeger, H Erdjument-Bromage, P Tempst, BM Spiegelman
Genes & development 2004
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
TC Leone, JJ Lehman, BN Finck, PJ Schaeffer, AR Wende, S Boudina, M Courtois, DF Wozniak, N Sambandam, C Bernal-Mizrachi, Z Chen, JO Holloszy, DM Medeiros, RE Schmidt, JE Saffitz, ED Abel, CF Semenkovich, DP Kelly
Cell 2004
Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle
JM Huss, IP Torra, B Staels, V Giguère, DP Kelly
Molecular and cellular biology 2004
Heart mitochondria signaling pathways: appraisal of an emerging field
J Marn-Garca, MJ Goldenthal
Journal of Molecular Medicine 2004
Mitochondrial signaling pathways: A receiver/integrator organelle
MJ Goldenthal, J Marín-García
Molecular and Cellular Biochemistry 2004
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo
A Meirhaeghe, V Crowley, C Lenaghan, C Lelliott, K Green, A Stewart, K Hart, S Schinner, JK Sethi, G Yeo, MD Brand, RN Cortright, S O'Rahilly, C Montague, AJ Vidal-Puig
Biochemical Journal 2003
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5
MP Czubryt, J McAnally, GI Fishman, EN Olson
Proceedings of the National Academy of Sciences 2003
PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity
Y Kamei, H Ohizumi, Y Fujitani, T Nemoto, T Tanaka, N Takahashi, T Kawada, M Miyoshi, O Ezaki, A Kakizuka
Proceedings of the National Academy of Sciences 2003
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
C Handschin, J Rhee, J Lin, PT Tarr, BM Spiegelman
Proceedings of the National Academy of Sciences 2003
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
J Rhee, Y Inoue, JC Yoon, P Puigserver, M Fan, FJ Gonzalez, BM Spiegelman
Proceedings of the National Academy of Sciences 2003
Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle
H Pilegaard, B Saltin, PD Neufer
The Journal of Physiology 2003
Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles
A Garnier, D Fortin, C Deloménie, I Momken, V Veksler, R Ventura-Clapier
2003
Regulation of Mitochondrial Biogenesis in Muscle by Endurance Exercise:
I Irrcher, PJ Adhihetty, AM Joseph, V Ljubicic, DA Hood
Sports Medicine 2003
Emerging paradigms for understanding fatness and diabetes risk
SR Smith, E Ravussin
Current Diabetes Reports 2002
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
H Zong, JM Ren, LH Young, M Pypaert, J Mu, MJ Birnbaum, GI Shulman
Proceedings of the National Academy of Sciences 2002
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
LF Michael, Z Wu, RB Cheatham, P Puigserver, G Adelmant, JJ Lehman, DP Kelly, BM Spiegelman
Proceedings of the National Academy of Sciences 2001
Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
D Knutti, D Kressler, A Kralli
Proceedings of the National Academy of Sciences 2001
Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells
U Andersson, RC Scarpulla
Molecular and cellular biology 2001

← Previous 1 2 … 19 20 21 22 23 24 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 8 patents
413 readers on Mendeley
1 readers on CiteULike
See more details