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CONGENITAL SPCA DEFICIENCY: A HITHERTO UNRECOGNIZED COAGULATION DEFECT WITH HEMORRHAGE RECTIFIED BY SERUM AND SERUM FRACTIONS
B. Alexander, … , Eunice Addelson, Claire Wilson
B. Alexander, … , Eunice Addelson, Claire Wilson
Published June 1, 1951
Citation Information: J Clin Invest. 1951;30(6):596-608. https://doi.org/10.1172/JCI102477.
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CONGENITAL SPCA DEFICIENCY: A HITHERTO UNRECOGNIZED COAGULATION DEFECT WITH HEMORRHAGE RECTIFIED BY SERUM AND SERUM FRACTIONS

Abstract

Authors

B. Alexander, R. Goldstein, G. Landwehr, C. D. Cook, Eunice Addelson, Claire Wilson

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Citations to this article (182)

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Biochemical, molecular and clinical aspects of coagulation factor VII and its role in hemostasis and thrombosis
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T Suda, S Hoshino, Y Takagi, K Iwasaki, Y Makuuchi, S Katayanagi, Y Nagakawa, T Hagiwara, K Shinozawa, A Seshimo, K Katsumata, K Fukutake, A Tsuchida 		The Japanese Journal of Gastroenterological Surgery 2020
Clinical Problems and Surgical Interventions in Inherited Factor VII Deficiency
B Koc 		TURK PEDIATR ARSIVI 2020
The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann–Pick C1-Like 1
S Kobayashi 		International journal of molecular sciences 2019
Congenital Factor VII Deficiency with Bleeding after Surgery for Advanced Gastric Cancer
S Sasaki, T Kurata, S Hagino, Y Shoji, I Terada, A Yoshikawa, H Kitagawa, T Fujimura, R Izumi 		The Japanese Journal of Gastroenterological Surgery 2019
ISOLATED CONGENITAL FACTOR VII DEFICIENCY
AS Somkuwar, S Merchant, R Meshram, M Waghmare, M Mahalinge, T Somkuwar 		2019
Congenital Bleeding Disorders: Diagnosis and Management
A Dorgalaleh 		2018
Environmental Nanotechnology
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Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K
Y Yamanashi, T Takada, R Kurauchi, Y Tanaka, T Komine, H Suzuki 		Journal of Atherosclerosis and Thrombosis 2017
Pediatric cardiac intervention in a case of congenital factor VII deficiency: a challenge to overcome
D De, HK Nayak, SS Datta, N Islam, S Halder 		Indian Journal of Hematology and Blood Transfusion 2017
Management of Surgical Third Lower Molar Extraction and Postoperative Progress in Patients With Factor VII Deficiency: A Clinical Protocol and Focus on This Rare Pathologic Entity
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Anticoagulation and Hemostasis in Neurosurgery
O Iqbal, P OMalley, N Guler 		Anticoagulation and Hemostasis in Neurosurgery 2016
Hereditärer heterozygoter Faktor VII-Mangel beim chirurgischen Patienten: Klinische Relevanz
D Woehrle, M Martinez, D Bolliger 		Der Anaesthesist 2016
Bleeding manifestations in heterozygotes with congenital FVII deficiency: a comparison with unaffected family members during a long observation period
A Girolami, E Cosi, S Ferrari, B Girolami, AM Lombardi 		Hematology 2016
NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy
T Takada, Y Yamanashi, K Konishi, T Yamamoto, Y Toyoda, Y Masuo, H Yamamoto, H Suzuki 		Science Translational Medicine 2015
A Case of Successful Endoscopic Submucosal Dissection of Gastric Adenoma in a Patient with Congenital Factor VII Deficiency
SH Kim, SH Choi, JW Lee, WJ Shin, CS Bang, GH Baik 		The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015
Use of recombinant factor VII for tooth extractions in a patient with severe congenital factor VII deficiency
RJ Weinstock, A Onyejiuwa, G Shnayder, EI Clarkson 		The Journal of the American Dental Association 2015
Pancreaticoduodenectomy for Hemorrhagic Gastrointestinal Stromal Tumor of the Duodenum with Congenital Factor VII Deficiency
Y Nakano, H Terashima, T Mafune, S Tsukamoto, S Paku, F Imamura, T Marumori, M Kamiga 		The Japanese Journal of Gastroenterological Surgery 2015
A case of hemorrhage after thoracoscopic surgery for spontaneous pneumothorax with congenital FVII deficiency successfully treated by recombinant activated factor VII (rFVIIa)
M Jinbo, H Gohra 		The Journal of the Japanese Associtation for Chest Surgery 2014
Management of Pregnancy in a Chilean Patient with Congenital Deficiency of Factor VII and Glanzmann’s Thrombasthenia Variant
NP Murray, C Garcia, J Ilabaca, N Lagos 		2014
Factor VII Deficiency in Pregnancy and Labour: A Case Report
E Ciantar 		2014
Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven(®))
NS Bartosh, T Tomlin, C Cable, K Halka 		Clinical pharmacology : advances and applications 2013
Pathogenetic Role of Factor VII Deficiency and Thrombosis in Cross-Reactive Material Positive Patients
A Girolami, L Sambado, E Bonamigo, S Ferrari, AM Lombardi 		Laboratory Hematology 2013
Laboratory Hematology Practice: Kottke-Marchant/Laboratory Hematology Practice
R Green 		Laboratory Hematology Practice: Kottke-Marchant/Laboratory Hematology Practice 2012
Factor VII Deficiency: A Single-Center Experience
Z Salcioglu, A Akcay, HS Sen, G Aydogan, F Akici, D Tugcu, NA Ayaz, Z Baslar 		Clinical and Applied Thrombosis/Hemostasis 2012
Historical perspective and future direction of coagulation research
H Saito, T Matsushita, T Kojima 		Journal of Thrombosis and Haemostasis 2011
Historical perspective and future direction of coagulation research: Past, present and future of coagulation research
H Saito, T Matsushita, T Kojima 		Journal of Thrombosis and Haemostasis 2011
Asymptomatic factor VII deficiency: gene analysis and structure–function relationships
D Kirkel, TW Lin, SW Fu, JS Dlott, MA Sahud, T McCaffrey, FR Rickles 		Blood Coagulation & Fibrinolysis 2010
Textbook of Hemophilia
A Goodeve 		Textbook of Hemophilia 2010
Vitamins & Hormones
KJ Hare, FK Knop 		Vitamins & Hormones 2010
Factor VII Deficiency: A Rare Case Report
R Mahale, P Rathi, C Ginegiri, R Aggarwal 		Indian Journal of Hematology and Blood Transfusion 2010
Familial factor VII deficiency with foetal and neonatal fatal cerebral haemorrhage associated with homozygosis to Gly180Arg mutation
D Landau, N Rosenberg, A Zivelin, O Staretz-Chacham, J Kapelushnik 		Haemophilia 2009
Using a minigene approach to characterize a novel splice site mutation in humanF7gene causing inherited factor VII deficiency in a Chinese pedigree
T Yu, X Wang, Q Ding, Q Fu, J Dai, Y Lu, X Xi, H Wang 		Haemophilia 2009
Factor VII deficiency: defining the clinical picture and optimizing therapeutic options
M Lapecorella, G Mariani 		Haemophilia 2008
The mutation in Japanese congenital factor VII deficiency
O TAKAMIYA 		Japanese Journal of Thrombosis and Hemostasis 2008
Clinical pictures and prevalence of factor VII deficiency in Northeastern of Iran
H Mansouritorghabeh, Z Badiei, F Noori 		Haemophilia 2007
Enseñanzas del factor VII activo recombinante. Diez años desde su autorización en la hemofilia complicada con inhibidor
J Batlle, MF Fernández 		Medicina Clínica 2007
Less Common Congenital Disorders of Hemostasis
HR Roberts, MA Escobar 		Consultative Hemostasis and Thrombosis 2007
Consultative Hemostasis and Thrombosis
VJ Marder 		Consultative Hemostasis and Thrombosis 2007
A Child With Severe Nosebleeds
N Gupta, D Kamat 		Clinical Pediatrics 2007
Theories of Blood Coagulation
JP Riddel, BE Aouizerat, C Miaskowski, DP Lillicrap 		Journal of Pediatric Oncology Nursing 2007
Advances in Enzymology - and Related Areas of Molecular Biology
H Waelsch 		Advances in Enzymology and Related Areas of Molecular Biology 2006
Hemophilia
KY Yoo 		Korean Journal of Pediatrics 2006
Genetics of Coagulation: Considerations for Cardiac Surgery
ST Morozowich, BS Donahue, IJ Welsby 		Seminars in cardiothoracic and vascular anesthesia 2006
Congenital Combined Defects of Factor VII: A Critical Review
A Girolami, E Ruzzon, F Tezza, E Allemand, S Vettore 		Acta Haematologica 2006
Lack of bleeding in patients with severe factor VII deficiency
JM Barnett, KC Demel, AE Mega, JN Butera, JD Sweeney 		American Journal of Hematology 2005
Mild factor VII deficiency due to heterozygosis is not associated with a bleeding tendency:
A Girolami, S Vettore, E Bortoletto, E Zanon 		Blood Coagulation & Fibrinolysis 2005
FORUM
KW Denson 		Journal of Thrombosis and Haemostasis 2004
Two novel mutations in severe factor VII deficiency
K Gomez, MA Laffan, G Kemball-Cook, J Pasi, M Layton, JD Singer, EG Tuddenham, JH McVey 		British Journal of Haematology 2004
Allosteric Modification of Factor XIa Functional Activity upon Binding to Polyanions
D Sinha, KO Badellino, M Marcinkiewicz, PN Walsh 		Biochemistry 2004
Oscar ratnoff: his contributions to the golden era of coagulation research
HR Roberts 		British Journal of Haematology 2003
The partial thromboplastin time: defining an era in coagulation
GC White 		Journal of Thrombosis and Haemostasis 2003
Six Characters in Search of An Author: The History of the Nomenclature of Coagulation Factors
PL Giangrande 		British Journal of Haematology 2003
A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation
EW Davie 		The Journal of biological chemistry 2003
Novel mutations in the Factor VII gene of Taiwanese Factor VII-deficient patients
MC Shen, JS Lin, SW Lin, WS Yang, B Lin 		British Journal of Haematology 2001
Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO 		Japanese Journal of Thrombosis and Hemostasis 2001
Inhibition of Tissue Factor-Activated Platelets by Low-Molecular-Weight Heparins and Glycoprotein IIb/IIIa Receptor Antagonist
S Ahmad, WP Jeske, Q Ma, JM Walenga, J Fareed 		Thrombosis Research 2001
Localization of a Heparin Binding Site in the Catalytic Domain of Factor XIa
KO Badellino, PN Walsh 		Biochemistry 2001
Factor VII deficiency and the FVII mutation database
JH McVey, E Boswell, AD Mumford, G Kemball-Cook, EG Tuddenham 		Human Mutation 2000
Historical review
EB MD 		British Journal of Haematology 2000
Isolated Factor VII Deficiency Diagnosed after a Life-Threatening Brain Haemorrhage
T Tsuda, Y Okamoto, R Sakaguchi, N Katayama, K Ota 		J INT MED RES 2000
29. Hämophilie-Symposion
I Scharrer, W Schramm 		2000
Protease Nexin II Interactions with Coagulation Factor XIa Are Contained within the Kunitz Protease Inhibitor Domain of Protease Nexin II and the Factor XIa Catalytic Domain
KO Badellino, PN Walsh 		Biochemistry 2000
28. Hämophilie-Symposion Hamburg 1997
I Scharrer, W Schramm 		1999
The Laboratory of Coagulation A review of present laboratory techniques
Khan, Snyder, Pechet 		Journal of Thrombosis and Thrombolysis 1999
Clinical picture and treatment strategies in factor VII deficiency
J Ingerslev, HL Kristensen 		Haemophilia 1998
Postoperative bleeding with factor VII deficiency: Case report
JC Cheng, RW Wong, BS Yan 		Australian Dental Journal 1998
Development of a subdural vein thrombosis following aggressive factor VII replacement for postnatal intracranial haemorrhage in a homozygous factor VII-deficient infant
Worth, Hoots 		Haemophilia 1998
Two new missense mutations (P134T and A244V) in the coagulation factor VII gene
C Alshinawi, C Scerri, R Galdies, A Aquilina, AE Felice 		Human Mutation 1998
Tissue Factor and Biotechnology
DM Martin, MT Wiiger, H Prydz 		Thrombosis Research 1998
Severe Factor VII Deficiency Due to a Mutation Disrupting an Sp1 Binding Site in the Factor VII Promoter
JA Carew, ES Pollak, KA High, KA Bauer 		Blood 1998
Neonatal intracranial hemorrhage secondary to congenital factor VII deficiency: Two case reports
H Ariffin, HP Lin 		American Journal of Hematology 1997
Congenital factor VII deficiency presenting as delayed bleeding following dental extraction. A review of the role of factor VII in coagulation
DC Wei, RW Wong, EP Robertson 		Pathology 1997
Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: Perioperative treatment with factor VII concentrate
A Brunori, R Greco, G Oddi, AD Blasio, F Chiappetta 		Neurosurgical Review 1997
Congenital factor VII deficiency in a patient with an abdominal aortic aneurysm
A Arroyo, J Porto, R Gesto 		Journal of Vascular Surgery 1996
25. Hämophilie-Symposion Hamburg 1994
I Scharrer, W Schramm 		1996
Congenital deficiency of factor VII in subarachnoid hemorrhage
ML Papa, G Schisano, A Franco, P Nina 		Stroke; a journal of cerebral circulation 1994
Molecular analysis of factor VII deficiency in Italy: a frequent mutation (FVII Lazio) in a repeated intronic region
F Bernardi, P Patracchini, D Gemmati, M Ferrati, P Arcieri, M Papacchini, R Redaelli, F Baudo, G Mariani, G Marchetti 		Human Genetics 1993
Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7)
G Marchetti, P Patracchini, D Gemmati, V DeRosa, M Pinotti, G Rodorigo, A Casonato, A Girolami, F Bernardi 		Human Genetics 1992
2 Inherited bleeding disorders
VS Blanchette, C Sparling, C Turner 		Baillière's Clinical Haematology 1991
Anesthésie et déficit en facteur VII de la coagulation
D Baudouin, MC Gilly-Geneste, J Fusciardi 		Annales Françaises d’Anesthésie et de Réanimation 1990
20. Hämophilie-Symposion Hamburg 1989
G Landbeck, R Marx, I Scharrer, W Schramm 		1990
Combined factor VII and protein C deficiency found in a patient with peripheral pulmonary artery stenosis accompanied by progressive pulmonary hypertension and hemoptysis
Y Takeuchi, Y Saito, H Ikenouchi, T Sugimoto, T Sugoh, Y Sakata, M Matsuda, O Takamiya 		Thrombosis Research 1988
Factor VII activity and antigen in a patient with abnormal factor VII
O TAKAMIYA, S FUNAHASHI, S KINOSHITA, A YOSHIOKA, K YOSHIOKA, H IKAWA 		Clinical & Laboratory Haematology 1988
Rare Factor Vii Variant Inherited Through Genetic Variant in Proband'S Mother and Another Genetic Variant in Proband'S Father
J Svendsen, B østerud 		Pediatric Hematology-Oncology 1987
Multiple extractions in a patient with factor VII deficiency
Y Sumi, M Shikimori, T Kaneda, T Kitajima 		Journal of Oral and Maxillofacial Surgery 1985
Rarer Quantitative and Qualitative Abnormalities of Coagulation
A Girolami, LD Marco, RD Zanon, G Patrassi, MG Cappellato 		Clinics in Haematology 1985
Carriers of factor VII deficiency are not always asymptomatic
M Bhavnani, DI Evans 		Clinical & Laboratory Haematology 1984
Inherited Bleeding Disorders in the Newborn Infant
DR Barnard 		Clinics in Perinatology 1984
7 Transfusion Support for Congenital Clotting Deficiencies Other than Haemophilia
JH Lewis, JA Spero, MV Ragni, FA Bontempo 		Clinics in Haematology 1984
Hereditary Factor VII Deficiency in a Chinese Family
LY Shih, IJ Hung 		Scandinavian Journal of Haematology 1983
Inherited factor X deficiency: Presentation of a case with etiologic and treatment considerations
JR Eastman, DA Triplett, AR Nowakowski 		Oral Surgery, Oral Medicine, Oral Pathology 1983
Studies on a family with the factor VII defect.
Zwierzina WD, Kunz F, Glatzl J 		Blut 1983
Factor VII deficiency in an East Indian family
CG Lopez, A Thiruselvam, RA Hutton 		Clinical & Laboratory Haematology 1982
Further studies on factor VII padua defect: the report of the fourth homozygous patient from the same valley
A Girolami, A Gaio, L Doglioni, M Procidano, P Saltarin 		Blut Zeitschrift für die Gesamte Blutforschung 1982
Factor VII deficiency
MV Ragni, JH Lewis, JA Spero, U Hasiba 		American Journal of Hematology 1981
Klinische Studien bei famili�rem heredit�rem Faktor-VII-Mangel
E Pilger, H Schenk, J Haralambus, S Sailer 		Blut Zeitschrift für die Gesamte Blutforschung 1981
Intracranial hemorrhage in congenital factor VII deficiency
KK Matthay, MA Koerper, AR Ablin 		The Journal of Pediatrics 1979
Congenital factor VII deficiency: Ein Bericht �ber vier neue F�lle
R Zimmermann, G Ehlers, W Ehlers, H Voss, U Gbel, U Wahn 		Blut Zeitschrift für die Gesamte Blutforschung 1979
A Syndrome of Factor VII Deficiency and Abnormal Platelet Release Reaction
B Ly, NO Solum, AM Vennerød, O Dahl, I Hagen, KH ØRstavik 		Scandinavian Journal of Haematology 1978
Benjamin Alexander (1909 – 1978)
S Niewiarowski 		Thrombosis Research 1978
Coagulopathies
JH Lewis, JA Spero, U Hasiba 		Disease-a-Month 1977
Deep Vein Thrombosis and Pulmonary Embolism in Congenital Factor VII Deficiency
ME Gershwin, JK Gude 		New England Journal of Medicine 1973
Congenital factor VII deficiency a case report
A Girolami, G Cattarozzi, G Mengarda, M Lazzarin 		Blut Zeitschrift für die Gesamte Blutforschung 1973
Congenital "Hypoprothrombinemias": Deficiency of Factors II, VII, and X
RA Seeler 		Medical Clinics of North America 1972
Thrombosis and Bleeding Disorders
EF Mammen 		Thrombosis and Bleeding Disorders 1971
Nonmechanical causes of surgical bleeding
D Silver, FH McGregor 		Current Problems in Surgery 1970
Blood Clotting Enzymology
CR Harmison, EF Mammen 		Blood Clotting Enzymology 1967
Erkrankungen der Stützgewebe Erkrankungen des Blutes und der Blutbildenden Organe
H Weicker, H Althoff, G Baumgartner, R Beckmann, K Betke, M Bettex, GR Burgio, H Cottier, R Damerow, KH Degenhardt, K Diemer, R Emrich, F Fey, H Fichsel, G Flatz, L Garby, C Gasser, E Gugler, HG Hansen, H Hauke, H Haupt, WH Hitzig, O Hövels, H Jacobi, S Jéquier, JH Jonxis, HJ Kaufmann, EF Kleihauer, W Künzer, E Kuhnke, J Laissue, B Leiber, EF Lüscher, WA Maier, HR Marti, H Merker, JD Murken, J Oehme, K Ofteringer, W Plenert, HJ Rind, G Rogner, B Roos, G Ruhrmann, F Schmid, H Schönenberg, G Schröder, J Spranger, H Stobbe, K Theiler, G Thomas, O Tönz, H Versé, M Vest, G Weippl, H Weyers, HR Wiedemann, G Wilhelm 		1967
Congenital Combined Deficiency of Coagulation Factors II, VII, IX and X: Report of a Case
CW McMillan, HR Roberts 		New England Journal of Medicine 1966
Vererbung von Hautkrankheiten
H Fritz-Niggli, EG Jung, W Klunker, GE Korn-Heydt, H Niermann, HO Curth, T Šalamon, UW Schnyder, E Sohar, GG Wendt, D Wise, L Ziprkowski, HA Gottron 		1966
Purification of a Bovine Plasma Protein (Factor VII) Which Is Required for the Activity of Lung Microsomes in Blood Coagulation
WJ Williams, DG Norris 		The Journal of biological chemistry 1966
The Proteins Composition, Structure, and Function
EW Davie, OD Ratnoff 		The Proteins Composition, Structure, and Function 1965
Entzündliche Dermatosen II
SR Brunauer, P Gross, O Hornstein, EG Jung, H Kuske, WF Lever, C March, JT McCarthy, RT McCluskey, A Miescher, PA Miescher, F Pascher, NF Rothfield, R Schuppli, H Storck, MB Sulzberger, L Zala, G Miescher 		1965
Clinical aspects of congenital factor VII deficiency
VJ Marder, NR Shulman 		The American Journal of Medicine 1964
Congenital deficiency of factor VII (hypoconvertinemia)
CA Owen, MA Amundsen, JH Thompson, JA Spittell, EJ Bowie, GG Stilwell, JS Hewlett, SD Mills, WG Sauer, RP Gage 		The American Journal of Medicine 1964
A clinical and family study of hereditary proconvertin (factor VII) deficiency
CA Hall, SI Rapaport, SB Ames, JA DeGroot, ES Allen, MA Ralston 		The American Journal of Medicine 1964
INACTIVATION OF PURIFIED AUTOPROTHROMBIN I WITH ANTITHROMBIN
WH Seegers, H Schröer, M Kagami 		Biochemistry and Cell Biology 1964
THE SEPARATION OF AUTOPROTHROMBIN I c FROM BOVINE PROTHROMBIN PREPARATIONS
WH Seegers, M Kagami 		Biochemistry and Cell Biology 1964
Thrombo-Embolism in Patients with Total Proconvertin (Factor VII) Deficiency
HC Godal, K Madsen, R Nissen-Meyer 		Acta Medica Scandinavica 1962
Anticoagulant therapy with coumarin congeners
B Alexander 		The American Journal of Medicine 1962
Blood Coagulation and Thrombotic Disease
B Alexander 		Circulation 1962
Proteolysis, Fibrinolysis, and Coagulation: Significance in Thrombolytic Therapy
B Alexander, L Pechet, A Kliman 		Circulation 1962
The problem of h�morrhage during an�sthesia and surgery
SA Feldman, V Marks 		Anaesthesia 1961
Increased Clotting Factors in Pregnancy
L Pechet, B Alexander 		New England Journal of Medicine 1961
Lehrbuch der Allgemeinen Humangenetik
F Vogel 		1961
DISAPPEARANCE RATE OF CONCENTRATED PROCONVERTIN EXTRACTS IN CONGENITAL AND ACQUIRED HYPOPROCONVERTINEMIA*
M Hoag, PM Aggeler, AH Fowell 		Journal of Clinical Investigation 1960
The Plasma Proteins
ML Petermann 		The Plasma Proteins 1960
Ergebnisse der Inneren Medizin und Kinderheilkunde
L Heilmeyer, R Schoen, B Rudder 		1960
Genetische H�mophilie-Probleme
F Vogel 		Langenbeck's Archives of Surgery 1960
The hereditary haemorrhagic diseases: their classification and diagnosis
AJ Quick 		British medical journal 1959
Surgical management in hemophilia and the hemophilioid diseases
IW BROWN, WW Smith, RM Howse 		Annals of Surgery 1959
Clotting Factor VII (Proconvertin): Synonymy, Properties, Clinical and Clinicolaboratory Aspects
B Alexander 		New England Journal of Medicine 1959
Preparation and Properties of Prothrombin
R Goldstein, AL Bolloc'h, B Alexander, E Zonderman 		The Journal of biological chemistry 1959
Application of Continuous Flow Electrophoresis to the Study of the Blood Coagulation Proteins and the Fibrinolytic Enzyme System. I. Normal Human Materials1
JH Lewis, D Walters, P Didisheim, WR Merchant 		Journal of Clinical Investigation 1958
Haemophilia and Related Conditions: A Survey of 187 Cases
R Biggs, RG Macfarlane 		British Journal of Haematology 1958
Blood-Clotting Substances with ‘Factor-VII’ Activity: A Comparison of Some Congenital and Acquired Deficiencies
FE Dische 		British Journal of Haematology 1958
Familial haemophilia and factor VII deficiency
M Constandoulakis 		Journal of clinical pathology 1958
Relation of Hemorrhage and Thrombosis to Prothrombin during Treatment with Coumarin-Type Anticoagulants
HS Sise, SM Lavelle, D Adamis, R Becker 		New England Journal of Medicine 1958
CONGENITAL DEFICIENCY OF FACTOR VII
WR Pitney 		1958
Zur Differentialdiagnose des angeborenen Faktor VII-Mangels
A Burmeister 		European Journal of Pediatrics 1958
Stuart Clotting Defect. I. Segregation of an Hereditary Hemorrhagic State from the Heterogeneous Group Heretofore Called “Stable Factor” (SPCA, Proconvertin, Factor VII) Deficiency
C Hougie, EM Barrow, JB Graham 		Journal of Clinical Investigation 1957
Stuart Clotting Defect. II. Genetic Aspects of a `New' Hemorrhagic State
JB Graham, EM Barrow, C Hougie 		Journal of Clinical Investigation 1957
Die angeborene familiäre Hypoprokonvertinämie
UM Serafini, F Pericoli 		Blut Zeitschrift für die Gesamte Blutforschung 1957
The effect of hepatic lobectomy on some blood clotting factors and on fibrinolysis
MB Zucker, M Siegel, EE Cliffton, JW Bellville, WS Howland, CE Grossi 		Annals of Surgery 1957
The therapy of disorders of coagulation
MC Rosenthal 		Journal of Chronic Diseases 1957
Hemorrhagic Disorders
I Schulman, Z Currimbhoy 		Pediatric Clinics of North America 1957
Dreiundsechzigster Kongress
K Miehlke 		1957
THE PHARMACY OF BLOOD, ITS PRODUCTS AND SUBSTITUTES*
JE Jorpes 		Journal of Pharmacy and Pharmacology 1956
Congenital factor VII deficiency; a review with a report of a case in an Indian infant
H Cohen, HC Falcke, HB Greig, M Simon 		Archives of disease in childhood 1956
The Activation of Prothrombin
WH Seegers 		Angiology 1956
Fünfter Kongress der Europäischen Gesellschaft für Hämatologie, Freiburg i. Br., 20. bis 24. September 1955 / Cinquième Congrès de la Société Européenne d’Hématologie, Freiburg i. Br., Allemagne, 20–24 Septembre 1955
H Begemann 		1956
Fünfter Kongress der Europäischen Gesellschaft für Hämatologie
H Begemann 		1956
The two-stage prothrombin assay in study of bleeding and clotting disorders
JH Ferguson, JH Lewis, JW Fresh 		The Yale journal of biology and medicine 1955
Neue Ergebnisse der Hämophilie-Forschung
F Vogel 		Blut Zeitschrift für die Gesamte Blutforschung 1955
Current pediatric references
AB Schwartz 		The Journal of Pediatrics 1955
Coagulation, Hemorrhage and Thrombosis
B Alexander 		New England Journal of Medicine 1955
A COAGULATION DISORDER DUE TO A FACTOR VII–LIKE DEFECT
ND Hicks 		The Medical Journal of Australia 1955
Neuere Auffassungen über den Mechanismus der Blutgerinnung
R Marbet, A Winterstein 		Experientia 1954
�ber den Bildungsmechanismus der Gerinnungsfaktoren Prothrombin und Faktor VII
HG Lasch, L Roka 		Klinische Wochenschrift 1954
Haemophilia and related conditions
RG Macfarlane 		Postgraduate medical journal 1954
Clinical implications of plasma fractionation
IH Scheinberg 		Bulletin of the New York Academy of Medicine 1954
Haemorrhagic diathesis due to deficiency of factor VII
JS Jenkins 		Journal of clinical pathology 1954
The coagulation of human blood
JF Ackroyd 		Postgraduate medical journal 1954
Angeborener Faktor V-Mangel. (Owrensche Krankheit)
F Heni, I Krauss 		Klinische Wochenschrift 1954
Syndrome hémorragique congénital dû au défaut du facteur de coagulation récemment isolé sous le nom de Facteur VII, Convertine, S.P.C.A
JL Beaumont, J Bernard 		Acta Medica Scandinavica 1953
The measurement of prothrombin in plasma; a case of prothrombin deficiency
R Biggs, AS Douglas 		Journal of clinical pathology 1953
Mechanism of blood coagulation in normal and pathologic conditions
M Stefanini 		The American Journal of Medicine 1953
Prothrombin and accessory factors
PA Owren 		The American Journal of Medicine 1953
Blood Cells and Plasma Proteins
B Alexander 		Blood Cells and Plasma Proteins 1953
Parahemophilia in three siblings (Owren's disease)
B Alexander, R Goldstein 		The American Journal of Medicine 1952
The Diagnosis and Management of Hemorrhagic Disorders
WN Valentine 		The Medical clinics of North America 1952
Hematology
JJ Shea, JJ Shea 		The Laryngoscope 1949

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