Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Is cyclooxygenase-2 the alpha and the omega in cancer?
Stephen M. Prescott
Stephen M. Prescott
Published June 1, 2000
Citation Information: J Clin Invest. 2000;105(11):1511-1513. https://doi.org/10.1172/JCI10241.
View: Text | PDF
Commentary Article has an altmetric score of 1

Is cyclooxygenase-2 the alpha and the omega in cancer?

  • Text
  • PDF
Abstract

Authors

Stephen M. Prescott

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
COX-2 expression in multiple cells in tumors of different stages. The se...
COX-2 expression in multiple cells in tumors of different stages. The sequence of events shown has been constructed from studies with multiple types of cancer. For example, the work on the earliest events was from mouse and human experiments on adenomatous polyps of the colon, in which the earliest expression of COX-2 (shown in red) is in the stromal cells. In several types of cancers, COX-2 is found in multiple cells in the late stages. Metastatic tumors in bone and various other organs express COX-2 in the metastatic cells and surrounding cells. In the case of bone, osteoclasts, which degrade the bone matrix and allow growth of the newly metastasized tumor, are among these COX-2+ cells.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 1 X users
19 readers on Mendeley
1 readers on CiteULike
See more details