CHEMICAL, CLINICAL AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION: XXXII. THE COAGULATION DEFECT IN HEMOPHILIA. AN IN VITRO AND IN VIVO COMPARISON OF NORMAL AND HEMOPHILIC WHOLE BLOOD, PLASMA AND DERIVED PLASMA PROTEIN FRACTIONS

^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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^{Thorndike Memorial Laboratory, Second and Fourth Medical Services, Boston City Hospital, Boston}

^{Department of Medicine, Harvard Medical School, Boston}

This paper is No. 44 in the “Studies of Plasma Proteins” of the Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

Some of the products of plasma fractionation used in this work were developed from blood collected for the American Red Cross by the Department of Physical Chemistry, Harvard Medical School, under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.

The expenses of this investigation were defrayed in part by a Gift to Harvard University from Smith, Kline and French Laboratories, of Philadelphia, and in part by a grant given “in recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

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