Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice
Paul A. Crossey, … , Claire C. Pillai, John P. Miell
Paul A. Crossey, … , Claire C. Pillai, John P. Miell
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):411-418. https://doi.org/10.1172/JCI10077.
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Article Genetics

Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice

Abstract

Research Article

Authors

Paul A. Crossey, Claire C. Pillai, John P. Miell

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Western ligand and immunoblot analysis of amniotic fluid hIGFBP-1. (a) W...
Western ligand and immunoblot analysis of amniotic fluid hIGFBP-1. (a) Western ligand blot of amniotic fluid from transgenic (tg) and wild-type (wt) fetuses from F+/M– matings. Human IGFBP-1 migrates with an apparent molecular weight of 30–32 kDa. A high-molecular-weight IGFBP (40–46 kDa) whose size is consistent with that of variantly glycosylated IGFBP-3 was also detected. (b) Western immunoblot analysis of amniotic fluid from the membrane shown in a using a mouse anti–hIGFBP-1 monoclonal antibody (mAb 6305). e, embryonic day.