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178 Posts
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Examining the role of cullin 3 in hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt) is a rare monogenic disease that results from mutations in the kinases WNK1 and WNK4 or mutations in the ubiquitin ligase cullin 3 (CUL3) or the CUL3 substrate adaptor kelch-like 3...
Published September 29, 2014
Author's Take
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is being investigated for clinical use as a treatment for obesity; however, the mechanism of a...
Published September 9, 2014
Author's Take
Examining plasma fibronectin in hemostasis
Platelet accumulation and coagulation are key processes required to stop bleeding following blood vessel injury. Plasma fibronectin, which circulates freely in the blood, contains collagen, fibrin, and integrin binding sites and is well poised...
Published September 2, 2014
Author's Take
Insulin secretory granule replenishment requires SORCS1
There is a strong association between obesity and type 2 diabetes (T2D); however, the majority of obese individuals do not develop T2D, supporting that genetic predisposition is an important component of the disease. Alan Attie and colleagues previo...
Published August 26, 2014
Author's Take
Application of adult-derived human satellite cells
Muscle satellite cells are a rare regenerative population in adult skeletal muscle and have potential to repair damaged muscle tissue. In this episode, Simone Spuler and colleagues demonstrate that satellite cells can be successfully expanded from h...
Published August 26, 2014
Author's Take
Reversal of senescent phenotypes in human T cells
Age-related declines in immune function result in enhanced susceptibility to infection and decreased vaccine efficacy. While aged immune cells exhibit signs of cellular senescence, such as a reduced proliferative capacity, many maintain effector fun...
Published August 1, 2014
Author's Take
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid polypeptide (IAPP). Human IAPP is potentially toxic and has been shown to accumulate withi...
Published July 18, 2014
Author's Take
Evaluation of kisspeptin-54 for egg maturation
In virto fertilization (IVF) has helped millions of couples have children. While considered relatively safe, there are risks associated with this procedure. Among the more serious complications is the development of ovarian hyperstimulation syndrome...
Published July 18, 2014
Author's Take
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation of serine residues within the type II TGF-β receptor (TβRII) following activa...
Published July 1, 2014
Author's Take
MicroRNA-regulated network promotes pulmonary hypertension
Pulmonary hypertension is a complex disease that affects multiple vascular cell types, and mircoRNAs (miRNAs) have been implicated in the pathogenesis of this condition. In this episode, Stephen Chan discusses how his group used network theory to id...
Published June 24, 2014
Author's Take
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