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STALing B cell responses with CD22
Craig P. Chappell, Edward A. Clark
Craig P. Chappell, Edward A. Clark
Published June 3, 2013
Citation Information: J Clin Invest. 2013;123(7):2778-2780. https://doi.org/10.1172/JCI69670.
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Commentary

STALing B cell responses with CD22

Abstract

Suppressing unwanted humoral immune responses without compromising the host’s ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system’s ability to respond to unrelated antigens.

Authors

Craig P. Chappell, Edward A. Clark

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