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Citation Information: J Clin Invest. 1970;49(6):1266-1279. https://doi.org/10.1172/JCI106339.
Abstract
The effect of 5,5′-diphenylhydantoin on thyroxine metabolism was examined in five normal volunteers. Intravenous injection of radiothyroxine was followed by a 10-12 day control and subsequent 9-14 day treatment periods. During oral administration of diphenylhydantoin, plasma thyroxine concentration decreased to about 80% of its pretreatment level and the plasma radiothyroxine disappearance rate increased a maximum of 20% over control estimates. These changes were a result of increases in both urinary and fecal excretion of radioisotope.
Authors
P. R. Larsen, A. J. Atkinson Jr., H. N. Wellman, R. E. Goldsmith
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