Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
Dallas Jones, … , Laurie H. Glimcher, Antonios O. Aliprantis
Dallas Jones, … , Laurie H. Glimcher, Antonios O. Aliprantis
Published July 1, 2011
Citation Information: J Clin Invest. 2011;121(7):2534-2542. https://doi.org/10.1172/JCI46262.
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Science in Medicine

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

Abstract

Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which has been termed “osteoimmunology,” has resulted in the development of clinical therapeutics for seemingly disparate diseases linked by the common themes of inflammation and bone remodeling. Here, the important concepts and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.

Authors

Dallas Jones, Laurie H. Glimcher, Antonios O. Aliprantis

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Figure 1

Schematic of the immune system’s influence on skeletal remodeling.

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Schematic of the immune system’s influence on skeletal remodeling. The e...
The effect of growth factors, cytokines, and cell-surface molecules generated by lymphoid populations on osteoclast-mediated bone resorption and osteoblast-mediated bone formation are depicted for physiologic and pathologic conditions. Red lines represent the repressive effects, and green arrows represent the stimulatory effects that the specific factor has on the target bone cell population. Stromal cells reflect various mesenchymal-derived cells such as osteoblast-lineage cells and synovial fibroblasts. iPTH, intermittent PTH; cPTH, continuous PTH.