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B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice
Ying-Hua Wang, Betty Diamond
Ying-Hua Wang, Betty Diamond
Published July 17, 2008
Citation Information: J Clin Invest. 2008;118(8):2896-2907. https://doi.org/10.1172/JCI35618.
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Research Article Immunology

B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice

Abstract

Autoreactive B cells are regulated in the BM during development through mechanisms, including editing of the B cell receptor (BCR), clonal deletion, and anergy. Peripheral B cell tolerance is also important for protection from autoimmune damage, although the mechanisms are less well defined. Here we demonstrated, using a mouse model of SLE-like serology, that during an autoimmune response, RAG was reinduced in antigen-activated early memory or preplasma B cells. Expression of RAG was specific to antigen-reactive B cells, required the function of the IL-7 receptor (IL-7R), and contributed to maintenance of humoral tolerance. We also showed that soluble antigen could diminish a non-autoreactive antibody response through induction of BCR revision. These data suggest that tolerance induction operates in B cells at a postactivation checkpoint and that BCR revision helps regulate autoreactivity generated during an ongoing immune response.

Authors

Ying-Hua Wang, Betty Diamond

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