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Usage Information

Chemical modification: the key to clinical application of RNA interference?
David R. Corey
David R. Corey
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Review Series

Chemical modification: the key to clinical application of RNA interference?

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Abstract

RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.

Authors

David R. Corey

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Usage data is cumulative from November 2025 through November 2026.

Usage JCI PMC
Text version 1,400 178
PDF 365 24
Figure 412 1
Table 345 0
Citation downloads 259 0
Totals 2,781 203
Total Views 2,984
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ISSN: 0021-9738 (print), 1558-8238 (online)

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