The legacy of the Philadelphia chromosome
Gary A. Koretzky
Gary A. Koretzky
Published August 1, 2007
Citation Information: J Clin Invest. 2007;117(8):2030-2032. https://doi.org/10.1172/JCI33032.
View: Text | PDF
Review Series Introduction

The legacy of the Philadelphia chromosome

Abstract

The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered. This Review series includes contributions from individuals who performed critical experiments addressing some of the most important of these questions, reflecting the nearly 50 years of work inspired by Nowell’s initial finding. The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease.

Authors

Gary A. Koretzky

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Peter Nowell, discoverer of the Philadelphia chromosome, at the Septembe...
Peter Nowell, discoverer of the Philadelphia chromosome, at the September 2006 symposium in his honor, along with Brian Druker, Owen Witte (top row), Carlo Croce, Mark Greene, and Tony Hunter (bottom row).