Molecular regulation of HDL metabolism and function: implications for novel therapies
Daniel J. Rader
Daniel J. Rader
Published December 1, 2006
Citation Information: J Clin Invest. 2006;116(12):3090-3100. https://doi.org/10.1172/JCI30163.
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Science in Medicine

Molecular regulation of HDL metabolism and function: implications for novel therapies

Abstract

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

Authors

Daniel J. Rader

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Figure 4

Pathways of cholesterol efflux from macrophages.

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Pathways of cholesterol efflux from macrophages. Macrophages have severa...
Macrophages have several pathways for efflux of cholesterol. They efflux free cholesterol to lipid-poor apoA-I via the ABCA1 pathway and to mature HDL via the ABCG1 pathway. Both ABCA1 and ABCG1 are regulated by the nuclear receptor LXR, which is activated by binding of oxysterols, derived from free cholesterol. SR-BI also has the capacity to efflux free cholesterol to mature HDL.