One thing leads to another
Jules Hirsch
Jules Hirsch
Published October 15, 2004
Citation Information: J Clin Invest. 2004;114(8):1040-1043. https://doi.org/10.1172/JCI22993.
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Retrospectives

One thing leads to another

Abstract

In 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: “Well, one thing leads to another.” Let me remind the reader of what “things” were like in 1956 and how they might have related to Dole’s important contribution.

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Jules Hirsch

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Figure 2

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(A) Effects of fasting (average of eight experiments), corn oil (four ex...
(A) Effects of fasting (average of eight experiments), corn oil (four experiments) and insulin (four experiments) on concentration of NEFAs. (B) Effects of epinephrine (three experiments) and glucose (14 experiments) on concentration of NEFAs in plasma. (C) Reciprocal variations of glucose and NEFAs in plasma after ingestion of glucose. Figure and legend adapted from ref. 3.