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Clinical Medicine
Advancing chemokine research: the molecular function of CXCL8
Yiran Hou, Anna Huttenlocher
Yiran Hou, Anna Huttenlocher
Published May 15, 2024
Citation Information:
J Clin Invest.
2024;
134(10)
:e180984.
https://doi.org/10.1172/JCI180984
.
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100th Anniversary Viewpoints
Advancing chemokine research: the molecular function of CXCL8
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Abstract
Authors
Yiran Hou, Anna Huttenlocher
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Figure 1
CXCL8 concentration gradient determines neutrophil migration pattern.
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Neutrophils migrate toward regions with higher concentrations of CXCL8 when the CXCL8 gradient ranges from low to medium concentrations. This directionality can reverse when there are high concentrations of CXCL8.