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Clinical MedicineIn-Press PreviewMetabolismOncology
Open Access | 10.1172/JCI180516
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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Jiang, C.
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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Cohen, P.
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1Laboratory of Molecular Metabolism, The Rockefeller University, New York, United States of America
2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Center for Clinical and Translational Science, The Rockefeller University, New York, United States of America
4Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center, New York, United States of America
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America
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Osorio, J.
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Published June 20, 2024 - More info
BACKGROUND. Obesity is the foremost risk factor in the development of endometrial cancer (EC). However, the impact of obesity on the response to immune checkpoint inhibitors (ICI) in EC remains poorly understood. This retrospective study investigates the association between body mass index (BMI), body fat distribution, and clinical and molecular characteristics of EC patients treated with ICI.
METHODS. We analyzed progression-free survival (PFS) and overall survival (OS) in EC patients treated with ICI, categorized by BMI, fat mass distribution, and molecular subtypes. Incidence of immune-related adverse events (irAE) after ICI was also assessed based on BMI status.
RESULTS. 524 EC patients were included in the study. Overweight and obese patients exhibited a significantly prolonged PFS and OS compared to normal BMI patients after treatment with ICI. Multivariable Cox regression analysis confirmed the independent association of overweight and obesity with improved PFS and OS. Elevated visceral adipose tissue (VAT) was identified as a strong independent predictor for improved PFS to ICI. Associations between obesity and OS/PFS were particularly significant in the copy number-high/TP53abnormal (CN-H/TP53abn) EC molecular subtype. Finally, obese patients demonstrated a higher irAE rate compared to normal BMI individuals.
CONCLUSION. Obesity is associated with improved outcomes to ICI in EC patients and a higher rate of irAEs. This association is more pronounced in the CN-H/TP53abn EC molecular subtype.
FUNDING. NIH/NCI Cancer Center Support Grant P30CA008748 (MSK). K08CA266740 and MSK Gerstner Physician Scholars Program (J.C.O). RUCCTS Grant #UL1 TR001866 (N.G-B and C.S.J). Cycle for survival and Breast Cancer Research Foundation grants (B.W).