A monoclonal thyroid-stimulating antibody
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1667-1674. https://doi.org/10.1172/JCI16991.
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Article Autoimmunity

A monoclonal thyroid-stimulating antibody

Abstract

Research Article

Authors

Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies

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Epitope recognition within TSHR residues 317–366 by TAb-4, but not MS-1....
Epitope recognition within TSHR residues 317–366 by TAb-4, but not MS-1. MS-1 reacted similarly to both CHO-hTSHR (a) and NC35 (c) cells. However, strong immunoreactivity seen on CHO-hTSHR cells (b) by TAb-4 was lost on NC35 cells (d) lacking TSHR residues 317–366. The thick lines indicate CHO-hTSHR cells in a and b, and NC35 cells in c and d. The thin lines indicate CHO cells. Fluorescence intensity was measured in FL-2.